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Combination Drug Therapy (Combination Chemotherapy)

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Therapy with two or more separate preparations given for a combined effect.

Also Known As:

Combination Chemotherapy; Drug Therapy, Combination; Chemotherapy, Combination; Drug Polytherapy; Therapy, Combination Drug; Chemotherapies, Combination; Combination Chemotherapies; Combination Drug Therapies; Drug Polytherapies; Drug Therapies, Combination; Polychemotherapies; Polytherapies, Drug; Polytherapy, Drug; Therapies, Combination Drug; Polychemotherapy

Networked: 9625 relevant articles (1241 outcomes, 1525 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 15318
- Drug Therapy: 178671
  - Combination Drug Therapy: 9625
    - Highly Active Antiretroviral Therapy: 7338
    - Antineoplastic Combined Chemotherapy Protocols: 23

Experts

1.	Park, Se Hoon: 19 articles (02/2013 - 08/2002)
2.	Shitara, Kohei: 18 articles (06/2013 - 07/2006)
3.	Kang, Won Ki: 18 articles (02/2012 - 08/2002)
4.	Park, Young Suk: 17 articles (04/2015 - 12/2002)
5.	Park, Joon Oh: 16 articles (04/2015 - 08/2002)
6.	Bang, Yung-Jue: 15 articles (09/2014 - 01/2003)
7.	Lee, Jeeyun: 14 articles (02/2013 - 01/2004)
8.	Muro, Kei: 13 articles (08/2014 - 11/2009)
9.	Takahari, Daisuke: 13 articles (08/2014 - 01/2008)
10.	Sonpavde, Guru: 13 articles (01/2014 - 02/2006)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2005 - "Most institutes participated in nonrandomized trials designed to evaluate the safety and efficacy of combination chemotherapy, surgery, and radiotherapy in each group study and treated children with these tumors The results are reviewed and areas for future investigation are identified." 01/01/2010 - "Although the clinical outcome of the patients has improved dramatically with combination chemotherapy, significant challenges remain, including understanding of the factors that contribute to the malignant behavior of these tumor cells and developing subsequently optimal targeted therapy. " 11/01/2004 - "The best results were achieved in patients with pT2A tumor invasion depth, G1 differentiation of tumor cells after TUR with adjuvant polychemotherapy (PCT) recurrences in these patients arose by 41.2% less frequently than in patients after TUR only, 5-year survival in patients after TUR+PCT was 83.3%. " 06/01/1999 - "With the consistent use of effective multimodal treatment, including combination chemotherapy, surgery and radiotherapy, the prognosis for all types of childhood cancer has dramatically improved over the last 25 years and the current 5-year survival rate is about 60-98%. " 01/01/1990 - "The polychemotherapy followed by the radiotherapy should be preferably applied to patients with tumors of the disease group A, because in this group the best results were obtained with an average survival time of 21.3 months, a remission length of 13.4 months, an improvement of life quality for 12.5 months and a high remission rate. "
2.	Stomach Neoplasms (Stomach Cancer) 12/01/2013 - "Recent studies have shown that combination chemotherapy of fluoropyrimidine and EGFR-targeting agents is effective for gastric cancer patients highly expressing EGFR. " 10/01/2011 - "In the setting of metastatic or inoperable gastric cancer, the current evidence shows that chemotherapy improves survival in comparison to best supportive care and that combination chemotherapy is superior to monotherapy in terms of survival, response rate and symptom control. " 01/01/2010 - "To assess the efficacy of chemotherapy versus best supportive care, combination versus single agent chemotherapy and different combination chemotherapy regimens in advanced gastric cancer. " 05/01/2008 - "The S-1/PTX combination chemotherapy was thought to be effective for gastric cancer with peritoneal dissemination and made curative operation possible in this case." 01/01/2007 - "The modified FOLFOXIRI combination chemotherapy showed a very promising preliminary antitumor activity and was generally well tolerated as a first-line treatment of patients with metastatic gastric cancer."
3.	Neoplasm Metastasis (Metastasis) 10/01/1981 - "The best results were obtained with the use of the polychemotherapy in combination with radiotherapy: the index of the 3-year survival amounted to 38.5+/-14 per cent, while in the patients subjected to the monochemotherapy in combination with irradiation of the metastases it was equal to 3.8+/-3.7 per cent. " 05/19/1978 - "If remission is not achieved with combined hormonal and cytostatic treatment, radiotherapy to the choroid metastases in combination with polychemotherapy can be undertaken as second best." 10/10/2008 - "The rapid expansion in the use of improved combination chemotherapy regimens plus or minus biologics, to render initially unresectable metastases resectable has increased the percentage of patients eligible for potentially curative surgery. " 05/01/2006 - "Polychemotherapy rarely leads to long-lasting complete remission in patients with distant metastases. " 03/01/2007 - "In patients with distant lymph-node metastasis, even without adjacent organ invasion, radical surgery may not achieve a good outcome.1 Here, combination chemotherapy or chemo-radiotherapy may have some benefits."
4.	Carcinoma (Carcinomatosis) 12/01/1987 - "Because the follow-up of these patients suggests a marked improvement in outcome compared with similar patients treated traditionally with mastectomy or radiotherapy followed by adjuvant chemotherapy, we advocate more widespread use of combination chemotherapy before definitive treatment for stage III carcinomas of the breast." 08/01/1986 - "Complete remission with combination chemotherapy in metastatic breast carcinoma." 06/01/1986 - "Abdominopelvic irradiation was given to 18 stage II-IV ovarian carcinoma patients who completed cisplatinum-based combination chemotherapy, were in complete clinical remission, and who underwent second-look laparotomy. " 02/01/1984 - "Ventilation/perfusion relations in patients with small cell anaplastic carcinoma of the lung, obtaining complete remission during combination chemotherapy." 07/01/1980 - "By polychemotherapy we achieved in 13 metastatasized carcinomas of the mamma 4 partial and one complete remission, in 15 inoperable lung tumours we achieved four times a standstill of the growth and a complete remission over two years, whereas the tumours of the gastro-intestinal tract could be influenced less clearly. "
5.	Lymphoma (Lymphomas) 09/01/1988 - "Combination chemotherapy has dramatically improved the prognosis of patients with intermediate and high grade histologic subtypes of non-Hodgkin's lymphomas. " 01/01/1991 - "Initial results from studies with third-generation combination chemotherapy regimens for the treatment of aggressive non-Hodgkin's lymphomas (NHL) demonstrated complete remission (CR) rates higher than those reported with first-generation regimens. " 01/01/2010 - "The latter was initially considered as stage IE primary pulmonary lymphoma and was treated with combination chemotherapy resulting in complete remission. " 10/01/2003 - "Two cycles of combination chemotherapy induced the lymphoma to a complete remission/unconfirmed (CRu), but then the chemotherapy was discontinued due to severe side effects. " 04/01/1999 - "The first was a case of primary malignant lymphoma of the cervical spinal cord which had been previously treated with radiation to the spinal lesion and combination chemotherapies and entered complete remission. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Fluorouracil (Carac)
3.	Doxorubicin (Adriamycin)
4.	Cyclophosphamide (Cytoxan)
5.	Paclitaxel (Taxol)
6.	Platinum
7.	Etoposide (VP 16)
8.	docetaxel (Taxotere)
9.	Vincristine (Oncovin)
10.	gemcitabine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Aftercare (After-Treatment)
4.	Adjuvant Chemotherapy
5.	Laparotomy