[Blocking intrauterine infection by telbivudine in pregnant chronic hepatitis B patients].

Abstract

OBJECTIVE:

To investigate the efficacy of telbivudine on intrauterine hepatitis B virus (HBV) infection during the last stage of pregnancy.

METHODS:

61 pregnant chronic hepatitis B (CHB) patients were enrolled and 31 patients were treated by telbivudine 600 mg once daily, 30 patients in the control group were not received antiviral treatment. Maternal HBV DNA level and the HBsAg positive rate in newborns were investigated.

RESULTS:

The levels of serum HBV DNA in patients treated with Telbivudine were significantly reduced (t = 19.09, P less than 0.01). Compared with the control group, serum HBV DNA levels were significantly lower in telbivudine treated patients than those in the control group before parturition (t = 23.64, P less than 0.01). The infection rate of 7-month newborns were 0 and 13.33% (4/30), in telbivudine group and control group, respectively (x2 = 4.29, probability value less than 0.05).

CONCLUSIONS:

Telbivudine treatment can block intrauterine infection in pregnant chronic hepatitis B patients.

• Authors: Li-ju Zhang, Ling Wang
• Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (Zhonghua Gan Zang Bing Za Zhi) Vol. 17 Issue 8 Pg. 561-3 (Aug 2009) ISSN: 1007-3418 [Print] China
• PMID: 19719910 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• Antiviral Agents
• DNA, Viral
• Hepatitis B Surface Antigens
• Nucleosides
• Pyrimidinones
• Telbivudine
• Thymidine

Topics

• Administration, Oral
• Antiviral Agents (pharmacology, therapeutic use)
• DNA, Viral (blood)
• Female
• Hepatitis B Surface Antigens (blood)
• Hepatitis B virus (drug effects)
• Hepatitis B, Chronic (drug therapy, transmission, virology)
• Humans
• Infant
• Infant, Newborn
• Infectious Disease Transmission, Vertical (prevention & control)
• Nucleosides (pharmacology, therapeutic use)
• Pregnancy
• Pregnancy Complications, Infectious (drug therapy, virology)
• Pyrimidinones (pharmacology, therapeutic use)
• Telbivudine
• Thymidine (analogs & derivatives)
• Treatment Outcome