Kruppel-Like Factor 6

A Kruppel-like transcription factor that contains three C-terminal CYS2-HIS2 ZINC FINGERS and binds to GC RICH SEQUENCE (GC box) in upstream gene promoters. It functions as a transcriptional activator, tumor suppressor, and may regulate growth and development of B-cells.

Also Known As:

Networked: 64 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Narla, Goutham: 13 articles (03/2010 - 04/2004)
2.	Friedman, Scott L: 11 articles (02/2013 - 04/2004)
3.	Martignetti, John A: 8 articles (12/2009 - 04/2004)
4.	DiFeo, Analisa: 6 articles (12/2009 - 02/2008)
5.	Reeves, Helen L: 4 articles (07/2008 - 04/2004)
6.	Kim, Gun-Dong: 3 articles (01/2020 - 09/2016)
7.	Mahabeleshwar, Ganapati H: 3 articles (01/2020 - 09/2016)
8.	Bose, Santanu: 3 articles (05/2013 - 08/2011)
9.	Mgbemena, Victoria: 3 articles (05/2013 - 08/2011)
10.	Sangodkar, Jaya: 3 articles (12/2009 - 08/2008)

Related Diseases

1.	Inflammation (Inflammations) 10/01/2019 - "Kruppel-like factor 6 and miR-223 signaling axis regulates macrophage-mediated inflammation." 10/01/2019 - "Kruppel-like factor 6 and miR-223 signaling axis regulates macrophage-mediated inflammation." 01/01/2022 - "Moreover, kruppel Like Factor 6 (KLF6) mediated the protective effects of sitagliptin on endothelial monolayer permeability against HG. Collectively, sitagliptin reversed the HG-induced oxidative stress, inflammation, and increased permeability in HrGECs via regulating KLF6. " 09/30/2016 - "Kruppel-like Factor 6 Promotes Macrophage-mediated Inflammation by Suppressing B Cell Leukemia/Lymphoma 6 Expression."
2.	Infections 07/15/2012 - "In the current study, we identified Kruppel-like factor 6 (KLF6) as a critical transcription factor essential for iNOS gene expression during flu infection. " 08/17/2011 - "Previous studies have shown that Kruppel-like factor 6 (KLF6) could function as a trans-activator of TGF gene; however, whether KLF members play a role during infection is unknown. " 07/15/2012 - "Transactivation of inducible nitric oxide synthase gene by Kruppel-like factor 6 regulates apoptosis during influenza A virus infection."
3.	Respiratory Syncytial Virus Infections 05/01/2013 - "In the current study we have uncovered the mechanism of iNOS gene induction by identifying kruppel-like factor 6 (KLF6) as a critical transcription factor required for iNOS gene expression during RSV infection. "
4.	Neoplasms (Cancer) 01/01/2018 - "Kruppel-like factor 6 (KLF6) inactivation has been shown in some malignant tumors. " 12/01/2016 - "Kruppel-like factor 6 (KLF6) as a novel tumor suppressive gene participates in multiple biological behaviors and plays an important role in regulating tumor cell growth and invasion. " 10/01/2011 - "Accumulating evidence suggests that the tumor suppressor gene Kruppel-like factor 6 (KLF6) and its dominant-negative splice form KLF6-SV1 play important roles in both the development and progression of cancer. " 08/01/2010 - "Kruppel-like factor 6 (KLF6) was reported as tumor suppressor in multiple cancers. " 12/01/2009 - "Inactivation of Kruppel-like factor 6 and overexpression of Kruppel-like factor 6 splice variant 1 have been associated with the progression of a number of human cancers and even with patient survival. "
5.	Hepatocellular Carcinoma (Hepatoma) 12/01/2016 - "Kruppel-like factor 6 suppresses growth and invasion of hepatocellular carcinoma cells in vitro and in vivo." 09/01/2008 - "To investigate the roles of Kruppel-like factor 6 (KLF6) and its splice variant KLF6V on suppressing growth and inducing differentiation of human hepatocellular carcinoma hepG2 cells. " 06/28/2007 - "In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma." 03/01/2007 - "Loss of expression of Kruppel-like factor 6 in primary hepatocellular carcinoma and hepatoma cell lines." 10/22/2004 - "[A candidate tumor suppressor gene mutated in primary hepatocellular carcinoma: kruppel-like factor 6]."

Related Drugs and Biologics

1.	Sitagliptin Phosphate (Januvia)
2.	Transcription Factors (Transcription Factor)
3.	Trans-Activators (Trans-Acting Factor)
4.	Proteins (Proteins, Gene)
5.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
6.	Activating Transcription Factor 3
7.	E2F Transcription Factors
8.	Protein Isoforms (Isoforms)
9.	Member 2 Group A Nuclear Receptor Subfamily 4
10.	Forkhead Transcription Factors (Forkhead Box Proteins)

Related Therapies and Procedures

1.	Therapeutics
2.	Resuscitation
3.	Prostatectomy (Retropubic Prostatectomy)