KLF6 and iNOS regulates apoptosis during respiratory syncytial virus infection.

Human respiratory syncytial virus (RSV) is a highly pathogenic lung-tropic virus that causes severe respiratory diseases. Enzymatic activity of inducible nitric oxide (iNOS) is required for NO generation. Although NO contributes to exaggerated lung disease during RSV infection, the role of NO in apoptosis during infection is not known. In addition, host trans-activator(s) required for iNOS gene expression during RSV infection is unknown. In the current study we have uncovered the mechanism of iNOS gene induction by identifying kruppel-like factor 6 (KLF6) as a critical transcription factor required for iNOS gene expression during RSV infection. Furthermore, we have also uncovered the role of iNOS as a critical host factor regulating apoptosis during RSV infection.
AuthorsVictoria Mgbemena, Jesus Segovia, Te-Hung Chang, Santanu Bose
JournalCellular immunology (Cell Immunol) 2013 May-Jun Vol. 283 Issue 1-2 Pg. 1-7 ISSN: 1090-2163 [Electronic] United States
PMID23831683 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Inc. All rights reserved.
Chemical References
  • KLF6 protein, human
  • Kruppel-Like Transcription Factors
  • Proto-Oncogene Proteins
  • NOS2 protein, human
  • Nitric Oxide Synthase Type II
  • Animals
  • Apoptosis (physiology)
  • Chromatin Immunoprecipitation
  • Humans
  • Kruppel-Like Transcription Factors (genetics, metabolism)
  • Mice
  • Nitric Oxide Synthase Type II (genetics, metabolism)
  • Proto-Oncogene Proteins (genetics, metabolism)
  • Respiratory Syncytial Virus Infections (genetics, metabolism)
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transcriptional Activation

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