Superoxide Dismutase-1

A superoxide dismutase (SOD1) that requires copper and zinc ions for its activity to destroy SUPEROXIDE FREE RADICALS within the CYTOPLASM. Mutations in the SOD1 gene are associated with AMYOTROPHIC LATERAL SCLEROSIS-1.

Also Known As:

Networked: 2021 relevant articles (40 outcomes, 167 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Borchelt, David R: 30 articles (01/2021 - 03/2002)
2.	Andersen, Peter M: 27 articles (01/2022 - 06/2003)
3.	Marklund, Stefan L: 27 articles (01/2022 - 01/2004)
4.	Furukawa, Yoshiaki: 23 articles (01/2020 - 04/2005)
5.	Julien, Jean-Pierre: 19 articles (01/2020 - 11/2002)
6.	Cashman, Neil R: 17 articles (04/2022 - 12/2002)
7.	Aoki, Masashi: 17 articles (01/2021 - 04/2003)
8.	Brännström, Thomas: 17 articles (01/2021 - 01/2004)
9.	Pawlak, Dariusz: 17 articles (03/2019 - 01/2004)
10.	Pawlak, Krystyna: 17 articles (03/2019 - 01/2004)

Related Diseases

1.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/01/2020 - "The superoxide dismutase 1 (SOD1) mutation is one of the most notable causes of amyotrophic lateral sclerosis (ALS), and modifying the mutant SOD1 gene is the best approach for the treatment of patients with ALS linked to the mutations in this gene. " 10/01/2010 - "Vaccinations targeting extracellular superoxide dismutase 1 (SOD1) mutants are beneficial in mouse models of amyotrophic lateral sclerosis (ALS). " 01/01/2011 - "RNA interference (RNAi) is a potential cure for amyotrophic lateral sclerosis (ALS) caused by dominant, gain-of-function superoxide dismutase 1 (SOD1) mutations. " 10/01/2009 - "In this issue of Genes & Development, Hetz and colleagues (pp. 2294-2306) surprisingly show that inhibition of the UPR by knockout of XBP-1 causes a massive increase in autophagy, enhances clearance of superoxide dismutase 1 (SOD1) aggregates, and delays the development of amyotrophic lateral sclerosis. " 12/01/2022 - "Amyotrophic lateral sclerosis disease-related mutations disrupt the dimerization of superoxide dismutase 1 - A comparative molecular dynamics simulation study."
2.	Muscular Atrophy (Muscle Atrophy) 03/27/2015 - "In this study we analyzed the effects of ALS on bone using the well established G93A transgenic mouse model, which harbors an ALS-causing mutation in the gene encoding superoxide dismutase 1. We found that 4-month-old G93A mice with severe muscle atrophy had dramatically reduced trabecular and cortical bone mass compared with their sex-matched wild type (WT) control littermates. " 12/01/2017 - "Genome editing reduced mutant SOD1 protein by >2.5-fold in the lumbar and thoracic spinal cord, resulting in improved motor function and reduced muscle atrophy. " 01/01/2021 - "Muscle atrophy, weakness, and neuromuscular junction (NMJ) degeneration reminiscent of normal muscle aging are observed early in adulthood for mice deficient in Cu, Zn-superoxide dismutase (SOD, Sod1-/-). " 11/15/2019 - "To better elucidate the timeline of the various potential pathological factors, we performed a longitudinal study to simultaneously assess the gut microbiome, immunophenotype and changes in ileum and brain epigenetic marks relative to motor behavior and muscle atrophy in the mutant superoxide dismutase 1 (SOD1G93A) familial ALS mouse model. " 01/01/2013 - "Dominant mutations in Cu/Zn-superoxide dismutase (SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS), a fatal disorder characterized by the progressive loss of motor neurons and subsequent muscular atrophy. "
3.	Inflammation (Inflammations) 04/21/2021 - "Self-Assembled pH-Sensitive Polymeric Nanoparticles for the Inflammation-Targeted Delivery of Cu/Zn-Superoxide Dismutase." 01/01/2019 - "Suspected PNS inflammation was associated with men, longer disease duration, and a larger hypoechoic nerve area and was the dominant finding in superoxide dismutase 1 mutation carriers. " 01/01/2015 - "Superoxide Dismutase 1 Nanozyme for Treatment of Eye Inflammation." 03/15/2005 - "To analyze the therapeutic value of Cu/Zn-superoxide dismutase (SOD1) supplementation in an experimental model of radiation-induced intestinal inflammation and explore its mechanistic effects. " 06/13/2014 - "Hallmarks of CNS inflammation, including microglial and astrocyte activation, are prominent features in post-mortem tissue from amyotrophic lateral sclerosis (ALS) patients and in mice overexpressing mutant superoxide dismutase-1 (SOD1G93A). "
4.	Infections 12/01/2003 - "Our studies indicate that Cu,Zn superoxide dismutase effectively protects bacteria from phagocytic killing, and that the role in infection of the redundant sodC genes may vary in distinct Salmonella enterica serovars. " 01/08/2016 - "The Influenza Virus H5N1 Infection Can Induce ROS Production for Viral Replication and Host Cell Death in A549 Cells Modulated by Human Cu/Zn Superoxide Dismutase (SOD1) Overexpression." 01/01/2013 - "Allelic variation at the Cu-Zn superoxide dismutase (SOD1) locus has been shown to be associated with resistance of the snail, Biomphalaria glabrata, to infection by the trematode parasite, Schistosoma mansoni. " 04/21/2011 - "The expression of superoxide dismutase [Cu-Zn] precursor increased with infection time for all four strains but was significantly higher in the Houston-1 strain, which may increase the competitive advantage of Houston-1 in terms of survival in host cells and render it successful in invading host cells and stimulating cell proliferation. " 08/01/2000 - "[Cu,Zn]-Superoxide dismutase mutants of the swine pathogen Actinobacillus pleuropneumoniae are unattenuated in infections of the natural host."
5.	Ischemia 11/01/2011 - "17β-Estradiol-mediated increase in Cu/Zn superoxide dismutase expression in the brain: a mechanism to protect neurons from ischemia." 04/01/1991 - "The properties of Cu,Zn-superoxide dismutase (SOD) from rat liver after 2-hour total ischemia or after ischemia with subsequent 24-hour reperfusion were studied. " 08/01/1997 - "Postischemic infusion of Cu/Zn superoxide dismutase or SOD:Tet451 reduces cerebral infarction following focal ischemia/reperfusion in rats." 05/30/2006 - "In the present study, we investigated chronological changes in Cu,Zn-superoxide dismutase (SOD1) immunoreactivity and its protein levels in the hippocampal CA1 region of adult and aged gerbils after transient forebrain ischemia to compare ischemia-related changes in SOD1 in adult and aged gerbils. " 11/15/2016 - "On the other hand, we found that pre-treatment with DXT did not increase 4-hydroxy-2-noneal (a marker for lipid peroxidation) and significantly increased the expression of Cu, Zn-superoxide dismutase, an antioxidant, in the CA1 pyramidal neurons compared with non-treated those after ischemia-reperfusion. "

Related Drugs and Biologics

1.	Catalase
2.	Proteins (Proteins, Gene)
3.	Glutathione Peroxidase
4.	Enzymes
5.	Antioxidants
6.	Superoxide Dismutase
7.	Vaccines
8.	Glutathione (Reduced Glutathione)
9.	Malondialdehyde (Propanedial)
10.	Heme Oxygenase-1

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Axotomy
4.	Transplantation
5.	Artificial Respiration (Mechanical Ventilation)