Suppressor of Cytokine Signaling 1 Protein

A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS1 functions as a negative regulator of CYTOKINES that signal through the JANUS KINASES-STAT 3 TRANSCRIPTION FACTOR (JAK/STAT3) pathway by inhibiting the activity of JANUS KINASES.

Also Known As:

Networked: 17 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Marienfeld, Ralf: 2 articles (03/2022 - 07/2021)
2.	Moldenhauer, Gerhard: 2 articles (03/2022 - 07/2021)
3.	Möller, Peter: 2 articles (03/2022 - 07/2021)
4.	Tessmer, Claudia: 2 articles (03/2022 - 07/2021)
5.	Weissinger, Stephanie E: 2 articles (03/2022 - 07/2021)
6.	Zahn, Malena: 2 articles (03/2022 - 07/2021)
7.	Guo, Jianyu: 1 article (01/2021)
8.	He, Peiqing: 1 article (01/2021)
9.	Lan, Tian: 1 article (01/2021)
10.	Li, Hua: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 05/15/2007 - "In this study, we evaluate the role of suppressor of cytokine signaling protein 1 (SOCS1) in modulating the effects of type I IFNs (IFN-alpha and IFN-beta) in human neuroendocrine BON1 and CM tumor cells. " 10/01/2019 - "This review mainly focuses on the structure, transcriptional regulation and functions of SOCS1 protein, and finally describes the possible clinical role of SOCS1 protein in tumors." 01/01/2018 - "SOCS1 protein overexpression was obviously associated with advanced clinical stage, large tumor size, more lymph node metastasis, present distant metastasis, and malign histological grade. " 05/01/2020 - "SOCS1 protein, the negative regulatory protein of the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling pathway, may inhibit signaling of JAK-STAT pathway by several cytokines and has tumor suppressor activity. "
2.	Lymphoma (Lymphomas) 03/01/2022 - "Accumulating studies show that the tumour suppressor SOCS1 is one of the most frequently mutated genes in lymphomas, often affecting the coding sequence of SOCS1 protein. " 07/01/2021 - "SOCS1 protein expression was investigated on cell cultures and cytoblocks of SOCS1WT stably transfected HEK293T cells, lymphoma cell lines and lymphoid tissues. "
3.	Infections 01/01/2022 - "Furthermore, we found for the first time that duck SOCS1 protein was also modified by K48-linked polyubiquitination, whereas our previous study found that SOCS1 was upregulated during DTMUV infection. " 12/01/2020 - "IAV infection upregulated the suppressor of cytokine signaling (SOCS) protein SOCS1, and SOCS1 mediated the ubiquitination and degradation of JAK1. "
4.	Ovarian Neoplasms (Ovarian Cancer) 08/01/2019 - "The present study investigated the expression of SOCS1 mRNA and SOCS1 protein in ovarian cancer and normal ovary tissues using reverse transcription-quantitative polymerase chain reaction (PCR) and immunohistochemistry, and the methylation status of the CpG islands of SOCS1 mRNA in ovarian cancer tissue were examined using a methylation-specific PCR. " 08/01/2019 - "Consistent with this, the expression levels of SOCS1 protein in ovarian cancer specimens were significantly increased, while the methylation rate of SOCS1 mRNA was significantly decreased compared with that in the normal ovary tissues. "
5.	Type 2 Diabetes Mellitus (MODY) 01/01/2018 - "Structural insights into suppressor of cytokine signaling 1 protein- identification of new leads for type 2 diabetes mellitus." 01/01/2018 - "The study considers the Suppressor of cytokine signaling 1 (SOCS1) protein as a novel Type 2 diabetes mellitus (T2DM) drug target. "

Related Drugs and Biologics

1.	Cytokines
2.	Messenger RNA (mRNA)
3.	Janus Kinases
4.	Proteasome Endopeptidase Complex (Proteasome)
5.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
6.	Ubiquitin
7.	Interleukin-10 (Interleukin 10)
8.	Proteins (Proteins, Gene)
9.	Lipopolysaccharides
10.	c-Mer Tyrosine Kinase