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Ubiquitin

A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
Also Known As:
APF-1; ATP-Dependent Proteolysis Factor 1; HMG-20; High Mobility Protein 20; Ubiquitin, Human; ATP Dependent Proteolysis Factor 1; Human Ubiquitin
Networked: 9048 relevant articles (101 outcomes, 722 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Dickson, Dennis W: 36 articles (01/2021 - 04/2003)
2. Hasegawa, Masato: 29 articles (12/2022 - 12/2002)
3. Arai, Tetsuaki: 26 articles (11/2019 - 07/2002)
4. Trojanowski, John Q: 26 articles (12/2017 - 12/2002)
5. Akiyama, Haruhiko: 25 articles (12/2022 - 07/2002)
6. Dikic, Ivan: 24 articles (12/2022 - 05/2006)
7. Willis, Monte S: 24 articles (06/2022 - 10/2006)
8. Sandri, Marco: 24 articles (10/2021 - 04/2004)
9. Dou, Q Ping: 24 articles (01/2021 - 08/2002)
10. Patterson, Cam: 23 articles (01/2022 - 10/2004)

Related Diseases

1. Neoplasms (Cancer)
2. Muscular Atrophy (Muscle Atrophy)
3. Parkinson Disease (Parkinson's Disease)
4. Neurodegenerative Diseases (Neurodegenerative Disease)
5. Inflammation (Inflammations)

Related Drugs and Biologics

1. Proteasome Endopeptidase Complex (Proteasome)
2. Proteins (Proteins, Gene)
3. Ligases (Synthetase)
4. Proteasome Inhibitors
5. Synucleins
6. Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
7. Protein Aggregates
8. Peptide Hydrolases (Proteases)
9. Heat-Shock Proteins (Heat-Shock Protein)
10. DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Radiotherapy
4. Splints (Splint)
5. Denervation