Uterine Anomalies

Congenital abnormalities of the uterus that include uterus arcuatus and uterus bicornis unicollis. It appears to be a familial disorder with autosomal dominant inheritance. OMIM: 192000

Networked: 80 relevant articles (2 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Premature Birth (Birth, Premature)
2.	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)
3.	Habitual Abortion (Recurrent Miscarriage)
4.	Premature Obstetric Labor (Premature Labor)
5.	Pelvic Inflammatory Disease (Pelvic Inflammatory Diseases)

Experts

1.	Ozaki, Yasuhiko: 5 articles (05/2014 - 10/2006)
2.	Sugiura-Ogasawara, Mayumi: 4 articles (05/2014 - 10/2006)
3.	Suzumori, Nobuhiro: 2 articles (05/2014 - 01/2009)
4.	Kitaori, Tamao: 2 articles (12/2009 - 01/2009)
5.	Carp, H: 2 articles (01/2004 - 12/2001)
6.	Frances Fei, Y: 1 article (12/2022)
7.	O'Brien, Kathleen: 1 article (12/2022)
8.	Rosen, Monica W: 1 article (12/2022)
9.	Russell, Colin: 1 article (12/2022)
10.	Grigore, Ana Maria: 1 article (11/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Uterine Anomalies:

1.	Diethylstilbestrol (Stilbestrol)FDA Link 02/01/2007 - "HOXA10 expression is altered by diethylstilbestrol, leading to uterine anomalies. " 11/01/1998 - "However, there was no difference in the rates of previous preterm delivery, two midtrimester losses, two terminations of pregnancy, in utero diethylstilbestrol exposure, uterine anomalies, history of cone biopsy or parity. " 01/01/1981 - "Uterine anomalies were demonstrated by hysterosalpingography (HSG) in 4 of 5 diethylstilbestrol (DES) exposed young women with fertility disturbances. " 01/01/1981 - "Uterine anomalies in diethylstilbestrol-exposed women with fertility disorders." 11/01/2013 - "Women with uterine anomalies (unicornuate, bicornuate, septate or uterus exposed to diethylstilbestrol) were excluded and women with fibroids were identified for subanalysis. "
2.	17 alpha-Hydroxyprogesterone Caproate (Delalutin)FDA Link 04/01/2015 - "The objective of the study was to evaluate the efficacy of 17 alpha-hydroxyprogesterone caproate (17OHP-C) in prolonging gestation in patients with a short cervix and other risk factors for preterm delivery, such as previous preterm birth, cervical surgery, uterine anomalies, or prenatal diethylstilbestrol (DES) exposure. "
3.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/01/2017 - "Over the years, evidence-based treatments such as surgical correction of uterine anomalies or aspirin and heparin for antiphospholipid syndrome have improved the outcomes for couples with recurrent pregnancy loss. " 11/01/2002 - "Women with antiphospholipid syndrome were treated with clexane and aspirin; some patients with uterine anomalies underwent corrective surgery, and some cases of retarded endometrium were treated with hMG. "
4.	Heparin (Liquaemin)FDA LinkGeneric 01/01/2017 - "Over the years, evidence-based treatments such as surgical correction of uterine anomalies or aspirin and heparin for antiphospholipid syndrome have improved the outcomes for couples with recurrent pregnancy loss. "
5.	Misoprostol (Cytotec)FDA LinkGeneric 10/01/2017 - "Any case of failed medical termination of pregnancy after repeated doses of misoprostol should be carefully assessed to exclude the possibility of uterine anomalies (especially in a primigravida), before proceeding with dilatation and evacuation to minimise the risk of complications." 01/01/2011 - "The implications of uterine anomalies are not an argument in the discussion whether to use misoprostol for termination of pregnancy in developing countries with scarce diagnostics tools." 12/01/2006 - "As medical abortion with mifepristone and misoprostol becomes more prevalent, more studies are necessary to establish the dosage and regimens for multiple pregnancies associated with uterine anomalies."
6.	Mifepristone (RU 486)FDA Link 12/01/2006 - "As medical abortion with mifepristone and misoprostol becomes more prevalent, more studies are necessary to establish the dosage and regimens for multiple pregnancies associated with uterine anomalies."
7.	Histocompatibility Antigens (Histocompatibility Antigen)IBA 05/01/1998 - "Histocompatibility antigen studies in women with recurrent miscarriages and Müllerian uterine anomalies."
8.	alpha-Fetoproteins (alpha-Fetoprotein)IBA 07/01/1996 - "This study was undertaken to investigate the association between uterine anomalies and unexplained elevated maternal serum alpha-fetoprotein (MSAFP) concentrations during the early second trimester. "
9.	Antiphospholipid AntibodiesIBA 10/01/2017 - "A total of 156 Mexican RSA (with at least 2 consecutive abortions) unrelated patients and 152 unrelated healthy women were included, the presence of karyotype anomalies in the parents as well as uterine anomalies as well as antiphospholipid antibodies was excluded in patients; while all the controls presented at least two healthy pregnancies and no abortion. " 12/01/2001 - "uterine anomalies or antiphospholipid antibodies). " 10/01/2022 - "Established causes of recurrent miscarriage are antiphospholipid antibodies, uterine anomalies, and abnormal chromosomes in either partner, particularly translocations. " 05/01/2014 - "Established causes of recurrent miscarriage are antiphospholipid antibodies, uterine anomalies and abnormal chromosomes in either partner, particularly translocations. " 12/01/2010 - "Established causes of recurrent miscarriage are antiphospholipid antibodies, uterine anomalies and abnormal chromosomes in either partner, particularly translocations. "
10.	Anticardiolipin AntibodiesIBA 01/01/2018 - "Frequencies of abnormal results for evidence-based diagnostic tests considered definite or probable causes of RPL (karyotyping for parental chromosomal abnormalities, and 24-chromosome microarray evaluation for products of conception (POC); pelvic sonohysterography, hysterosalpingogram, or hysteroscopy for uterine anomalies; immunological tests for lupus anticoagulant and anticardiolipin antibodies; and blood tests for thyroid stimulating hormone (TSH), prolactin and hemoglobin A1c) were evaluated. " 03/01/2010 - "Frequencies of abnormal results for evidence-based diagnostic tests considered definite or probable causes of RPL (karyotyping for parental chromosomal abnormalities; pelvic sonohysterography, hysterosalpingogram, or hysteroscopy for uterine anomalies; immunological tests for lupus anticoagulant and anticardiolipin antibodies; thrombophilic tests for the factor V Leiden mutation; and blood tests for thyroid-stimulating hormone [TSH] and fasting blood glucose). "

Therapies and Procedures

1.	Cervical Cerclage 11/01/1991 - "The effect of cervical cerclage on the survival rate of the fetus was studied in 86 pregnancies of women with congenital uterine anomalies and a random group of 106 pregnancies in women with normal shaped uteri. " 11/01/1991 - "The role of cervical cerclage in the management of uterine anomalies." 01/01/2020 - "Women with symptoms of preterm labor, multiple gestations, fetal or uterine anomalies, cervical cerclage, or those with incomplete data were excluded from the study. " 10/01/2011 - "There are reports in which cervical cerclage has been shown to prevent preterm labor in uterine anomalies. "
2.	Curettage 01/01/1982 - "A curettage under sonographic control may reduce the risk of the curettage in cases of uterine anomalies, anomalies of the position or unusually soft uteri." 03/15/1983 - "There was no finding in the present study to indicate that the uterine anomalies were secondary to previous curettage, therapeutic abortion, operations on the uterus, or pelvic inflammatory disease." 11/01/2023 - "Log-binomial regression and Poisson regression were performed, adjusting for potential confounders including oocyte age, patient age, body mass index, prior EPL count, number of prior dilation and curettage procedures, leiomyomas, uterine anomalies, and vaginal bleeding. "
3.	Therapeutic Abortion 03/15/1983 - "There was no finding in the present study to indicate that the uterine anomalies were secondary to previous curettage, therapeutic abortion, operations on the uterus, or pelvic inflammatory disease."
4.	Cesarean Section (Caesarean Section) 03/29/2021 - "Both patients delivered healthy male infants at term via emergency and planned lower segment caesarean sections, indicating women with major uterine anomalies can have successful obstetric outcomes." 02/01/2019 - "Approximately 5% of women were found to have uterine anomalies when examined during caesarean section. " 02/01/2019 - "Of the 653 caesarean sections included, uterine anomalies were diagnosed in 31 women (4.75%). " 02/01/2019 - "Frequency and types of uterine anomalies during caesarean section." 07/01/2014 - "Patients with uterine anomalies had significantly higher rates of breech présentation (36.51% vs 4.52%; P<0.01) and cesarean section (55.26% vs 18.70%; P<0.01) compared to the group of women with a normal uterus. "
5.	Intrauterine Devices (Intrauterine Device) 12/28/2015 - "3D imaging of the uterus is now the preferred imaging modality for assessing congenital uterine anomalies and intrauterine device localization. " 01/01/2019 - "In patients with malpositioned intrauterine devices, there was increased incidence of retroflexed uterine positions (7.6% vs 1.8%, P = .001), and all uterine anomalies (this includes septate and bicornuate uteri and fibroids, 31.9% vs 23.5%, P = .02) compared with controls. " 01/01/2019 - "We hypothesized that anatomical characteristics such as the presence of any uterine anomalies, particularly congenital anomalies and fibroids that may lead to cavitary distortion, would be associated with a higher incidence of intrauterine device malposition. " 11/01/2021 - "The addition of 3D examination to 2D ultrasound in uterine pathology provided the most useful information concerning: Congenital uterine anomalies, intrauterine devices (IUDs), adenomyosis, and submucous myomas. " 10/01/2006 - "Added information included uterine anomalies, better definition of the endometrium, more accurate delineation and location of endometrial polyps, location of leiomyomas, visualization of cystic areas within the myometrium, and confirmation of the location of intrauterine devices. "