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Mifepristone (RU 486)

A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
Also Known As:
RU 486; Mifeprex; RU-486; RU486; Mifegyne; Mifégyne; R-38486; R38486; RU-38486; ZK-98296; ZK98296; R 38486; RU 38486; RU38486; ZK 98296; Estra-4,9-dien-3-one, 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-, (11beta,17beta)-
Networked: 1726 relevant articles (191 outcomes, 321 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Jia, Lee: 20 articles (07/2022 - 03/2014)
2. Check, Jerome H: 14 articles (12/2021 - 08/2007)
3. Telleria, Carlos M: 13 articles (11/2021 - 06/2007)
4. Goyeneche, Alicia A: 12 articles (11/2021 - 06/2007)
5. Liu, Jian: 12 articles (09/2021 - 01/2016)
6. Belanoff, Joseph K: 10 articles (01/2022 - 08/2002)
7. Check, Diane: 10 articles (12/2021 - 05/2009)
8. Wang, Jichuang: 10 articles (05/2019 - 03/2014)
9. Lu, Yusheng: 9 articles (07/2022 - 03/2014)
10. Gemzell-Danielsson, Kristina: 9 articles (01/2022 - 09/2003)

Related Diseases

1. Leiomyoma (Uterine Fibroids)
2. Neoplasms (Cancer)
3. Cushing Syndrome
4. Hemorrhage
5. Endometriosis

Related Drugs and Biologics

1. Misoprostol (Cytotec)
2. Glucocorticoid Receptors (Glucocorticoid Receptor)
3. Mifepristone (RU 486)
4. Progesterone Receptors (Progesterone Receptor)
5. Progesterone
6. Levonorgestrel (Plan B)
7. Glucocorticoids
8. Gonadotropin-Releasing Hormone (GnRH)
9. Steroids
10. asoprisnil

Related Therapies and Procedures

1. Therapeutics
2. Aftercare (After-Treatment)
3. Castration
4. Postcoital Contraception (Emergency Contraception)
5. Hysterectomy