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Urogenital Abnormalities

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Congenital structural abnormalities of the UROGENITAL SYSTEM in either the male or the female.

Also Known As:

Abnormalities, Urogenital; Abnormalities, Genitourinary; Abnormality, Genitourinary; Abnormality, Urogenital; Genitourinary Abnormality; Urogenital Abnormality; Genitourinary Abnormalities

Networked: 85 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Thromboembolism
2.	Neoplasms (Cancer)
3.	Breast Neoplasms (Breast Cancer)
4.	Mental Retardation (Idiocy)
5.	Aniridia

Experts

1.	Kanwar, Yashpal S: 2 articles (07/2005 - 11/2003)
2.	Chugh, Sumant S: 2 articles (07/2005 - 11/2003)
3.	Pigna, A: 2 articles (10/2003 - 01/2001)
4.	Baroncini, S: 2 articles (10/2003 - 01/2001)
5.	Gentili, A: 2 articles (10/2003 - 01/2001)
6.	Ricci, G: 2 articles (10/2003 - 01/2001)
7.	Frederick, Ann: 1 article (01/2016)
8.	Lawler, Elisabeth: 1 article (01/2016)
9.	Chang, Sandy: 1 article (01/2016)
10.	Ahmed, M Nadeem: 1 article (01/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Urogenital Abnormalities:

1.	Anti-Bacterial Agents (Antibiotics)IBA 12/01/2015 - "Cranberry appears effective for the prevention of UTIs in otherwise healthy children and is at least as effective as antibiotics in children with underlying urogenital abnormalities. " 12/01/2015 - "Five trials examined the use in pediatric patients with underlying urogenital abnormalities of which 2 compared cranberry to antibiotics. "
2.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA 09/01/2003 - "The aromatase inhibitors offer the potential to achieve these goals in part in the following ways: (a) greater reduction in risk of disease as evidenced by superior efficacy in advanced breast cancer and by inhibition of both initiation and promotion of breast cancer, (b) reduction in receptor-negative tumors by synergy with COX-2 inhibitors resulting in growth factor inhibition, anti-angiogenesis and inhibition of tumor-associated aromatase expression, (c) fewer vasomotor and urogenital abnormalities, and (d) reduced thromboembolism and cardiovascular complications and satisfactory effects on bone metabolism. "
3.	Aromatase InhibitorsIBA 09/01/2003 - "The aromatase inhibitors offer the potential to achieve these goals in part in the following ways: (a) greater reduction in risk of disease as evidenced by superior efficacy in advanced breast cancer and by inhibition of both initiation and promotion of breast cancer, (b) reduction in receptor-negative tumors by synergy with COX-2 inhibitors resulting in growth factor inhibition, anti-angiogenesis and inhibition of tumor-associated aromatase expression, (c) fewer vasomotor and urogenital abnormalities, and (d) reduced thromboembolism and cardiovascular complications and satisfactory effects on bone metabolism. "
4.	Aromatase (CYP19)IBA 09/01/2003 - "The aromatase inhibitors offer the potential to achieve these goals in part in the following ways: (a) greater reduction in risk of disease as evidenced by superior efficacy in advanced breast cancer and by inhibition of both initiation and promotion of breast cancer, (b) reduction in receptor-negative tumors by synergy with COX-2 inhibitors resulting in growth factor inhibition, anti-angiogenesis and inhibition of tumor-associated aromatase expression, (c) fewer vasomotor and urogenital abnormalities, and (d) reduced thromboembolism and cardiovascular complications and satisfactory effects on bone metabolism. "
5.	Hereditary renal agenesisIBA 12/01/1979 - "It is apparent from embryologic studies and numerous reports that up to 89% of females with unilateral renal agenesis are likely to have significant accompanying genitourinary abnormalities. " 01/01/2013 - "It has been associated with various genitourinary abnormalities, including renal agenesis. " 08/01/2002 - "A total of 54 (26.7%) had at least one genitourinary abnormality, the most frequent being unilateral renal agenesis. " 12/01/1979 - "Multiple genitourinary abnormalities in females with unilateral renal agenesis: three cases." 05/01/2001 - "We report a one year old girl with Fraser Syndrome (the association of craniofacial abnormalities, syndactaly and cryptophlamos) and multiple urogenital abnormalities including clitorimegaly, left renal agenesis and a unique urinary bladder exstrophy variant (psuedoexstrophy) with intact bladder which herniates through the lower abdominal wall defect."
6.	Diethylstilbestrol (Stilbestrol)FDA Link 12/07/1984 - "This study was designed to determine whether a cohort of males exposed in utero to diethylstilbestrol had a higher frequency of urogenital abnormalities than an unexposed cohort. " 01/01/2009 - "Urogenital abnormalities in men exposed to diethylstilbestrol in utero: a cohort study." 05/15/1983 - "A group of boys exposed to diethylstilbestrol (DES) in utero who had earlier been found to have urogenital abnormalities were studied for evidence of later effects of DES on their health, physical development and hormonal status. " 02/01/1977 - "Male genitourinary abnormalities and maternal diethylstilbestrol." 12/07/1984 - "Overall, the data suggest that diethylstilbestrol exposure of males in utero did not increase their risk of genitourinary abnormalities, infertility, or testicular cancer. "
7.	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 04/01/1998 - "Knowledge that mutations in the RET proto-oncogene cause MTC and studies documenting genitourinary abnormalities in RET or GDNF knockout mice led us to examine the GDNF/RET-GDNFR alpha signaling complex in this family. "
8.	LatexIBA 01/30/1998 - "Children with spina bifida or urogenital abnormalities, health care workers and workers in the latex industry are known to be high risk groups. " 01/01/1993 - "Similar cases have recently been described, especially in children with congenital urogenital abnormalities who are frequently exposed to latex (catheters, surgical gloves). " 10/01/2003 - "Latex allergy is frequently found in children and patients with spina bifida and urogenital abnormalities and have been considered at risk for latex sensitization. " 01/01/2001 - "Latex intraoperative allergy is more and more frequent, especially in at groups risk (patients with spina bifida or congenital genitourinary abnormalities, pluri-operated patients, atopic subjects) and in pediatric age. "
9.	Aarskog syndromeIBA 05/01/2015 - "Aarskog-Scott syndrome (AAS), also known as faciogenital dysplasia (FGD, OMIM # 305400), is an X-linked disorder of recessive inheritance, characterized by short stature and facial, skeletal, and urogenital abnormalities. " 01/01/2012 - "Aarskog-Scott syndrome [OMIM 100050] is a predominantly X-linked disorder that is phenotypically characterized by short stature, craniofacial dysmorphisms, brachydactyly and urogenital abnormalities. " 05/15/2005 - "Mutations of the FGD1 gene are responsible for a significant proportion of patients with Aarskog-Scott syndrome (AAS), an X-linked disorder characterized by short stature, brachydactyly, urogenital abnormalities, and a typical dysmorphic facial appearance. " 05/01/2007 - "Faciogenital dysplasia, also known as Aarskog-Scott syndrome (AAS), is an X-linked dominant congenital disorder characterized by multiple facial, musculoskeletal, dental, neurological and urogenital abnormalities, ocular manifestations, congenital heart defects, low IQ and behavioral problems. "
10.	Antley-Bixler syndromeIBA 01/01/2008 - "Antley-Bixler syndrome (ABS) is a rare congenital disorder characterized by numerous craniofacial, skeletal and, in some cases, urogenital abnormalities resulting from disordered steroidogenesis. " 09/01/2006 - "The Antley-Bixler syndrome (ABS) is a multiple congenital malformation syndrome with craniosynostosis, radiohumeral synostosis, femoral bowing, choanal atresia or stenosis, joint contractures, urogenital abnormalities and, often, early death. " 08/19/2011 - "Antley-Bixler syndrome (ABS) represents a group of heterogeneous disorders characterized by skeletal, cardiac, and urogenital abnormalities that have frequently been associated with mutations in fibroblast growth factor receptor 2 or cytochrome P450 reductase genes. "

Therapies and Procedures

1.	Catheters 01/01/1995 - "Appropriate management of anatomic genitourinary abnormalities and removal of bladder catheters may result in the resolution of candiduria, although some patients require systemic antifungal therapy. " 01/01/1993 - "Similar cases have recently been described, especially in children with congenital urogenital abnormalities who are frequently exposed to latex (catheters, surgical gloves). "
2.	Antibiotic Prophylaxis 04/01/2000 - "In children with recurrent UTIs and in those treated with antibiotic prophylaxis there is a greater incidence of UTI due to Proteus spp., Klebsiella spp. and Enterobacter spp., whereas Pseudomonas spp., Serratia spp. and Candida spp. are more frequent in children with urogenital abnormalities and/or undergoing invasive instrumental investigations. " 10/01/2012 - "Covariates included age, sex, insurance, race, vesicoureteral reflux, antibiotic prophylaxis, genitourinary abnormality, and chronic care conditions. "
3.	Transplants (Transplant) 08/01/2000 - "Strategies for management are based on the presence or absence of other features such as anatomic genitourinary abnormalities, renal transplant, and fever. "
4.	Kidney Transplantation 01/01/2015 - "However, we feel that it may be useful to perform routine angiographic evaluation for ESRD patients with congenital genitourinary abnormalities being planned for kidney transplantation. "
5.	Vasectomy (Vas Occlusion) 06/01/1980 - " The patient had no urogenital abnormalities and had an uneventful vasectomy procedure. "