Histocompatibility Antigens (Histocompatibility Antigen)

A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.

Also Known As:

Networked: 1123 relevant articles (10 outcomes, 73 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Goulmy, Els: 10 articles (01/2013 - 01/2002)
2.	Dolstra, Harry: 6 articles (06/2014 - 11/2008)
3.	Falkenburg, J H Frederik: 6 articles (08/2012 - 04/2002)
4.	Korngold, Robert: 5 articles (09/2015 - 12/2003)
5.	Pool, Jos: 5 articles (01/2013 - 01/2002)
6.	Mullen, Craig A: 5 articles (02/2011 - 01/2002)
7.	Mutis, Tuna: 5 articles (11/2010 - 01/2002)
8.	Goulmy, E: 4 articles (07/2010 - 01/2000)
9.	Friedman, Thea M: 4 articles (03/2007 - 12/2003)
10.	Murphy, George F: 4 articles (03/2007 - 12/2003)

Related Diseases

1.	Neoplasms (Cancer) 07/07/1997 - "This is known to be effective for class I-restricted cytotoxic T lymphocyte (CTL) cross-priming directed against a variety of exogenous tumor, viral, and minor transplantation antigens. " 05/01/2010 - "Concomitant tumor and minor histocompatibility antigen-specific immunity initiate rejection and maintain remission from established spontaneous solid tumors." 01/01/1986 - "Studies on histocompatibility antigens expression on different selected mouse tumor cells revealed very variable pattern. " 06/01/1977 - "Quantitative in vivo studies of soluble simian virus 40 tumor-specific transplantation antigens of the mouse." 01/01/1966 - "Studies on the occurrence of common specific transplantation antigens in Rous tumors of various mammalian species."
2.	Graft vs Host Disease (Graft-Versus-Host Disease) 09/01/2015 - "Inhibition of the Immunoproteasome Subunit LMP7 with ONX 0914 Ameliorates Graft-versus-Host Disease in an MHC-Matched Minor Histocompatibility Antigen-Disparate Murine Model." 03/15/2005 - "Mismatch for the adhesion molecule CD31 (PECAM-1) has been associated in some studies with graft-versus-host disease (GVHD), suggesting a role for CD31 as a minor histocompatibility antigen. " 07/15/2000 - "To study the role of the Fas/FasL pathway in the complex pathophysiology of graft versus host disease (GVHD), we used FasL-deficient B6.gld mice as recipients in a Major Histocompatibility Antigen Complex-matched minor Histocompatibility Antigen-mismatched murine model for GVHD after allogeneic BMT (C3H.SW-->B6). " 01/01/2013 - "Isolation of human CD4/CD8 double-positive, graft-versus-host disease-protective, minor histocompatibility antigen-specific regulatory T cells and of a novel HLA-DR7-restricted HY-specific CD4 clone." 01/01/2012 - "Acute graft-versus-host disease (aGVHD), an allogeneic reaction triggered in response to minor and major histocompatibility antigen disparities between donor and recipient, remains the main source of morbidity and mortality in T-cell-replete allogeneic HSCT. "
3.	Multiple Sclerosis 02/01/2013 - "Multiple sclerosis in Pakistan: histocompatibility antigen composition and disability." 10/01/2000 - "Histocompatibility antigen (HLA) associations with multiple sclerosis in Iran." 08/01/1998 - "[Histocompatibility antigens in multiple sclerosis in children]." 07/01/1998 - "The class II major histocompatibility antigen DR15 is associated with multiple sclerosis in all groups except Sardinians, where the primary association is with DR4. " 01/01/1998 - "[Characteristics of histocompatibility antigens distribution in patients with multiple sclerosis]."
4.	Neoplasm Metastasis (Metastasis) 03/01/1989 - "Phenotypic expression of histocompatibility antigens in human primary tumours and metastases." 11/01/1986 - "Allogeneic LAK cells had little, if any, therapeutic effect on established pulmonary and hepatic metastases when administered to recipients previously immunized to the histocompatibility antigens on the donor cells. " 12/01/1986 - "Variants of neoplasms MCA-F, MCA-D, and MCA-2A were selected for proclivity for spontaneous lung metastasis and expression of parental tumor-specific transplantation antigens. " 11/15/1985 - "The anomalous expression of histocompatibility antigens in many neoplasms appears to be associated with the ability of these cells to evade the immune system and progress to metastasis. " 10/01/1980 - "Preventive effect of Propionibacterium acnes on metastasis in mice rendered tolerant to tumor-associated transplantation antigens."
5.	Autoimmune Diseases (Autoimmune Disease) 05/01/1986 - "All eight patients with HAE who developed an autoimmune disease with a known human histocompatibility antigen association developed a disease associated with their histocompatibility antigen haplotype (p = 0.014). " 08/01/1985 - "[Histocompatibility antigens and autoimmune diseases]." 05/01/1984 - "Several autoimmune diseases have been associated with increased frequencies of various histocompatibility antigen (HLA) types that may be linked to immune response genes. " 12/01/1983 - "The histocompatibility antigens B8 and DR3 are associated with several autoimmune diseases, and immune hyper-responsiveness has been believed to be one factor in the pathogenesis of these diseases. " 05/01/1977 - "Autoimmune disease and histocompatibility antigen."

Related Drugs and Biologics

1.	Antigens
2.	tumor-associated transplantation antigen (TSTA)
3.	Methylcholanthrene
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Peptides
6.	Transforming Growth Factor beta1 (TGF beta 1)
7.	Interleukin-7 Receptor alpha Subunit
8.	Interferon alpha-beta Receptor (Receptor, Interferon alpha beta)
9.	CCR5 Receptors (CCR5 Receptor)
10.	rituximab (Mabthera)

Related Therapies and Procedures

1.	Immunotherapy
2.	Transplants (Transplant)
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Transplantation (Transplant Recipients)
5.	Homologous Transplantation (Allograft)