Antiphospholipid Antibodies

Autoantibodies directed against phospholipids. These antibodies are characteristically found in patients with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; related autoimmune diseases, some non-autoimmune diseases, and also in healthy individuals.

Also Known As:

Networked: 3369 relevant articles (32 outcomes, 251 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cervera, Ricard: 36 articles (10/2015 - 01/2003)
2.	Shoenfeld, Yehuda: 34 articles (09/2015 - 01/2002)
3.	Shoenfeld, Y: 33 articles (06/2012 - 04/2000)
4.	Atsumi, Tatsuya: 25 articles (03/2015 - 07/2002)
5.	Cervera, R: 23 articles (10/2012 - 10/2000)
6.	Khamashta, Munther A: 21 articles (11/2015 - 02/2002)
7.	Tincani, Angela: 20 articles (05/2015 - 09/2005)
8.	Koike, Takao: 20 articles (02/2012 - 01/2002)
9.	Asherson, Ronald A: 20 articles (12/2008 - 01/2003)
10.	Erkan, Doruk: 19 articles (11/2015 - 10/2003)

Related Diseases

1.	Thrombosis (Thrombus) 01/01/2014 - "No association was found when analyzing the risk for SLE among OC users, however since women with high disease activity/Thromboses or antiphospholipid-antibodies were excluded from most of the studies, caution should be exercised in interpreting the present results. " 03/01/2006 - "Search of MEDLINE (1966 to November 2005) and Cochrane Library electronic databases (2005) and reference lists for randomized trials, meta-analyses of randomized trials, and prospective cohort studies of the treatment of thrombosis risk in patients with antiphospholipid antibodies or APS. " 03/01/2003 - "The aim of this study was to evaluate the prevalence of anti-CD36 in patients with antiphospholipid antibodies (aPL) and its relationship with thrombosis. " 01/01/2002 - "The aim of the study was to determine whether the combined presence of two types of antiphospholipid antibodies can be associated with a high-risk subset of thrombosis-prone patients. " 01/01/2001 - "Antiphospholipid antibodies are positive in a high proportion of these patients but thrombosis were not found during the study duration. "
2.	Stroke (Strokes) 01/01/1993 - "This case provides further evidence that effective treatment for stroke associated with antiphospholipid antibodies is still wanting." 11/01/2008 - "In our study, stroke patients with antiphospholipid antibodies (APL) were significantly younger and were more likely to be women than stroke patients without APL. " 10/01/2005 - "No treatment trials have been conducted in young adults with antiphospholipid antibodies and stroke. " 10/01/2005 - "Only one of these studies evaluated for risk of recurrent stroke in young adults with antiphospholipid antibodies and found it to be increased. " 10/01/2005 - "Antiphospholipid antibodies are an independent risk factor for stroke in young adults in five of six studies. "
3.	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 10/01/2015 - "The aim of the study was to examine an extended panel of antiphospholipid antibodies in Ssc patients who did not have any clinical features of antiphospholipid antibody syndrome. " 11/01/2013 - "Antiphospholipid Syndrome Alliance For Clinical Trials and International Networking (APS ACTION) is an international research network devoted to conducting well-designed clinical trials in persistently antiphospholipid antibody (aPL)–positive patients. " 10/01/2013 - "Since other immunological disorders might affect the results, antiphospholipid antibodies (APA), which are the markers of antiphospholipid antibody syndrome, were also screened in all women prior to study. " 05/01/2013 - "Antiphospholipid antibodies (aPL) seem to induce a prothrombotic state by activating endothelium and platelets, but no studies have evaluated systematically the effects of aPL from patients with the antiphospholipid syndrome (APS) in quiescent versus catastrophic phase. " 06/01/2012 - "AntiPhospholipid Syndrome Alliance For Clinical Trials and InternatiOnal Networking (APS ACTION) is the first-ever international research network that has been created specifically to design and conduct well-designed, large-scale, multi-center clinical trials in persistently antiphospholipid antibody (aPL)-positive patients. "
4.	Fetal Death 06/15/2004 - "To evaluate the efficacy of a uniform management protocol in antiphospholipid-antibody-positive obstetric patients with at least one second- or third-trimester intra-uterine fetal death. " 11/01/1991 - "Antiphospholipid antibody measurements obtained at 15 weeks' gestation or later in the general pregnancy population are not helpful in identifying pregnancies at risk for fetal death." 07/01/2012 - "To investigate the association of antiphospholipid antibodies and a history of intrauterine fetal death (IUFD) in a case-control design. " 07/01/2012 - "The association of antiphospholipid antibodies with intrauterine fetal death: a case-control study." 06/15/2004 - "A prospective study of 33 successive pregnancies in antiphospholipid-antibody-positive patients, diagnosed after an intra-uterine fetal death. "
5.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 05/01/2014 - "Antiphospholipid antibodies in children with systemic lupus erythematosus: a long-term clinical and laboratory follow-up status study from northwest India." 01/01/2014 - "The aim of this study was to compare the cognitive function of antiphospholipid antibody (aPL)-negative systemic lupus erythematosus (SLE) and aPL-positive non-SLE patients. " 03/01/2011 - "This study aimed to determine the value of damage index in patients with systemic lupus erythematosus (SLE) and the association between damage index and disease severity, flare up numbers, disease duration, and antiphospholipid antibodies. " 10/01/2009 - "The objective is to study the neuropsychiatric (NP) manifestations in pediatric onset systemic lupus erythematosus (SLE) at a tertiary care hospital of northwestern India applying American College of Rheumatology (ACR) case definitions in the context of occurrence of antiphospholipid antibodies (APLA). " 07/01/2000 - "The aim of this study was to evaluate the incidence of morphologic and functional cardiac abnormalities in patients with systemic lupus erythematosus and correlate the data with antiphospholipid antibody (aPL) levels. "

Related Drugs and Biologics

1.	Aspirin (Acetylsalicylic Acid)
2.	Warfarin (Coumadin)
3.	Anticardiolipin Antibodies
4.	Antibodies
5.	Lupus Coagulation Inhibitor (Lupus Anticoagulant)
6.	Immunoglobulin G (IgG)
7.	Immunoglobulin M (IgM)
8.	Cardiolipins (Cardiolipin)
9.	Creatinine
10.	Prednisone (Sone)

Related Therapies and Procedures

1.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
2.	Renal Dialysis (Hemodialysis)
3.	Transplantation (Transplant Recipients)
4.	Plasmapheresis
5.	Immunotherapy