Heparin (Liquaemin)

A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.

Also Known As:

Networked: 18766 relevant articles (1275 outcomes, 2327 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Warkentin, Theodore E: 117 articles (12/2015 - 06/2002)
2.	Greinacher, Andreas: 81 articles (11/2015 - 03/2002)
3.	Mehran, Roxana: 67 articles (11/2015 - 09/2003)
4.	Stone, Gregg W: 63 articles (04/2015 - 08/2004)
5.	White, Harvey D: 48 articles (03/2015 - 06/2002)
6.	Walenga, Jeanine M: 47 articles (03/2015 - 01/2002)
7.	Hursting, Marcie J: 43 articles (01/2011 - 03/2002)
8.	Greinacher, A: 40 articles (08/2015 - 03/2000)
9.	Lincoff, A Michael: 39 articles (06/2011 - 05/2002)
10.	Cohen, Marc: 37 articles (10/2015 - 01/2002)

Related Diseases

1.	Thrombosis (Thrombus) 04/01/2002 - "Although various types of heparin coatings were effective in reducing (sub)acute thrombosis, most of them failed to reduce neointimal proliferation. " 01/01/1999 - "Unfractionated heparin (UH), administered subcutaneously in low doses of 5000 U every 12 h, is safe and effective in preventing thrombosis in most patients. " 01/01/1994 - "In the event of a marked decrease in platelet count associated with venous or arterial thrombosis, heparin therapy should be stopped immediately. " 05/01/2002 - "With improved surgical techniques, the use of heparin-based thromboprophylactic agents has allowed significant advances in the prevention of thrombosis during the past 30 years. " 10/01/1994 - "Right atrial thrombus can be treated successfully with heparin, leading to its resolution and a normal pregnancy outcome."
2.	Hemorrhage 12/01/2007 - "Heparin use provides the best results but may be associated with a higher mortality rate related to intra-abdominal bleeding. " 01/01/2006 - "However, heparin therapy is not always associated with a significant improvement of clinical outcomes, is linked with enhanced bleeding risk and can occasionally provoke the development of heparin-induced thrombocytopaenia, the most devastating complication of conventional therapy with unfractioned heparin. " 08/01/2004 - "The aim of this study was to investigate whether clinically important bleeding attributable to heparin rebound can be eliminated by infusion of small amounts of additional protamine for 6 hours postoperatively and whether this treatment can reduce mediastinal blood loss. " 11/15/1994 - "APC improved the prolonged bleeding time, but heparin aggravated bleeding with potent prolongation of activated partial thromboplastin time (APTT). " 02/01/1978 - "Neither heparin's therapeutic efficacy nor its ability to increase bleeding could be proven. "
3.	Venous Thrombosis (Deep-Vein Thrombosis) 09/01/1988 - "The purpose of this prospective, randomized study was to evaluate the efficacy of low-dose heparin, alone or in combination with electric stimulation, in the prevention of deep vein thrombosis (DVT) in C2 to T11 motor complete and incomplete-preserved motor, nonfunctional spinal cord injured patients. " 01/01/1991 - "Native heparin was very effective in models of arterial and venous thrombosis as well as in a model demonstrating the effect on endothelial stability in rats. " 01/01/1984 - "Although the results are not statistically significant, this study suggests that a single dose of heparin given intravenously during operation is a safe and effective means of prophylaxis against deep-vein thrombosis in patients who undergo general surgical procedures. " 02/26/1982 - "Further studies with larger numbers of patients are required in order to show a significant reduction in the incidence of post-operative deep vein thrombosis in hip surgery patients receiving low-dose adjusted heparin." 08/15/1998 - "The administration of subcutaneous heparin according to a weight-based algorithm allows the rapid achievement of effective and safe anticoagulation in patients with deep venous thrombosis."
4.	Myocardial Infarction 11/01/2000 - "A safe and effective regimen without heparin therapy after successful primary coronary stenting in patients with acute myocardial infarction." 03/10/2009 - "Although weight-based nomograms have improved the efficacy and safety of dosing unfractionated heparin in ST-segment elevation myocardial infarction, achieving therapeutic anticoagulation in practice remains challenging. " 09/01/2001 - "The authors conclude that the use of low dose heparin appears effective and safe in cases without acute myocardial infarction. " 04/01/1990 - "SK and t-PA with or without post-thrombolytic heparin treatment appear equally effective and safe for use in routine conditions care, in all patients with acute myocardial infarction (AMI)." 11/01/1998 - "The safety and efficacy of bedside monitors of activated partial thromboplastin time (aPTT) have not been examined in a large population receiving intravenous heparin after thrombolytic treatment for acute myocardial infarction. "
5.	Thrombocytopenia (Thrombopenia) 01/01/2008 - "Successful management of acute thromboembolic disease complicated with heparin induced thrombocytopenia type II (HIT II): a case series." 07/01/2007 - "Because of its high sensitivity, we believe the PF4 ENHANCED enzyme-linked immunosorbent assay should be used to identify heparin-induced thrombocytopenia in patients with multiple potential causes of thrombocytopenia, although false-positive results will not be uncommon." 08/01/2005 - "Heparin-induced thrombocytopenia Type II (HIT II) is the autoimmune-mediated severe form of the disease characterized by a significant reduction in platelets, and it carries a high risk of "paradoxical" serious thrombotic complications. " 01/01/2015 - "Safety and efficacy of therapeutic agents used for heparin-induced thrombocytopenia are not established in pregnancy. " 05/01/1997 - "The results of a series of clinical trials reveal that LMWHs are at least as safe and effective as UFH for initial treatment, with the additional advantage of the possibility of home treatment without the requirement of laboratory control and with a reduced risk of heparin-induced thrombocytopenia. "

Related Drugs and Biologics

1.	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)
2.	Aspirin (Acetylsalicylic Acid)
3.	Enoxaparin (Lovenox)
4.	bivalirudin (Angiomax)
5.	Thrombin
6.	Warfarin (Coumadin)
7.	Glycoproteins (Glycoprotein)
8.	Heparin (Liquaemin)
9.	Hirudins
10.	Dalteparin (Dalteparin Sodium)

Related Therapies and Procedures

1.	Catheters
2.	Stents
3.	Transplants (Transplant)
4.	Angioplasty (Angioplasty, Transluminal)
5.	Renal Dialysis (Hemodialysis)