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Fibrochondrogenesis

Networked: 16 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Osteoarthritis
2.	type 1 Stickler syndrome
3.	Kniest dysplasia
4.	Desbuquois syndrome
5.	Pseudoachondroplasia

Experts

1.	Warnock, Jennifer J: 3 articles (01/2014 - 04/2011)
2.	Cook, James L: 2 articles (01/2014 - 04/2011)
3.	Fox, Derek B: 2 articles (01/2014 - 04/2011)
4.	Stoker, Aaron M: 2 articles (01/2014 - 04/2011)
5.	Ala-Kokko, Leena: 2 articles (02/2012 - 11/2010)
6.	Cohn, Daniel H: 2 articles (02/2012 - 11/2010)
7.	Funari, Tara: 2 articles (02/2012 - 11/2010)
8.	Krakow, Deborah: 2 articles (02/2012 - 11/2010)
9.	Nevarez, Lisette: 2 articles (02/2012 - 11/2010)
10.	Tompson, Stuart W: 2 articles (02/2012 - 11/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Fibrochondrogenesis:

1.	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 04/01/2011 - "To determine the in vitro effects of selected growth factors on fibrochondrogenesis by synovial membrane cells from nonosteoarthritic (normal) and osteoarthritic joints of dogs. " 04/01/2011 - "Evaluation of in vitro growth factor treatments on fibrochondrogenesis by synovial membrane cells from osteoarthritic and nonosteoarthritic joints of dogs." 03/01/2009 - "Fibrochondrogenesis of hESCs: growth factor combinations and cocultures." 01/01/2019 - "By designing a scaffold that eliminates the need for exogenous or systemic growth factor administration and demonstrating that fibrochondrogenesis requires a lower growth factor dose compared to previously reported, this study represents a critical step towards developing a clinical solution for regeneration of fibrocartilaginous tissues. "
2.	SolutionsIBA 01/01/2019 - "By designing a scaffold that eliminates the need for exogenous or systemic growth factor administration and demonstrating that fibrochondrogenesis requires a lower growth factor dose compared to previously reported, this study represents a critical step towards developing a clinical solution for regeneration of fibrocartilaginous tissues. "
3.	Fibrinogen (Factor I)FDA Link 10/01/2012 - "Of the blends examined, FA 40:8 (40 mg ml(-1) fibrinogen blended with 8 mg ml(-1) alginate) was found to be the most appropriate group for future studies on tension-driven BM-MSC fibrochondrogenesis. "
4.	AlginatesIBA 10/01/2012 - "Of the blends examined, FA 40:8 (40 mg ml(-1) fibrinogen blended with 8 mg ml(-1) alginate) was found to be the most appropriate group for future studies on tension-driven BM-MSC fibrochondrogenesis. "
5.	Collagen Type XIIBA 02/01/2012 - "Fibrochondrogenesis is a severe, recessively inherited skeletal dysplasia shown to result from mutations in the gene encoding the proα1(XI) chain of type XI collagen, COL11A1. " 11/12/2010 - "Fibrochondrogenesis results from mutations in the COL11A1 type XI collagen gene." 01/01/2018 - "Collagen is the major structural component of cartilage, and mutations in the genes encoding type XI collagen are associated with severe skeletal dysplasias (fibrochondrogenesis and Stickler syndrome) and early-onset osteoarthritis (OA). "
6.	CollagenIBA 01/01/2018 - "Collagen is the major structural component of cartilage, and mutations in the genes encoding type XI collagen are associated with severe skeletal dysplasias (fibrochondrogenesis and Stickler syndrome) and early-onset osteoarthritis (OA). " 04/01/2011 - "In the cultured cells, fibrochondrogenesis was measured by use of a real-time reverse transcriptase PCR assay to determine relative expressions of collagen I, collagen II, and aggrecan genes and of 3 genes involved in embryonic chondrogenesis: Sry-type homeobox protein-9 (SOX-9), frizzled-motif associated with bone development (Frzb), and regulator of G-protein signaling-10 (RGS-10). " 01/01/2014 - "The effect on fibrochondrogenesis was determined by comparing mRNA expression of collagen types Iα and IIα, aggrecan, and Sry-type homeobox protein-9 (SOX9) as well as protein expression of collagens I and II, glycosaminoglycan (GAG), and hydroxyproline. "
7.	Aggrecans (Aggrecan)IBA 04/01/2011 - "In the cultured cells, fibrochondrogenesis was measured by use of a real-time reverse transcriptase PCR assay to determine relative expressions of collagen I, collagen II, and aggrecan genes and of 3 genes involved in embryonic chondrogenesis: Sry-type homeobox protein-9 (SOX-9), frizzled-motif associated with bone development (Frzb), and regulator of G-protein signaling-10 (RGS-10). " 01/01/2014 - "The effect on fibrochondrogenesis was determined by comparing mRNA expression of collagen types Iα and IIα, aggrecan, and Sry-type homeobox protein-9 (SOX9) as well as protein expression of collagens I and II, glycosaminoglycan (GAG), and hydroxyproline. "
8.	Proteins (Proteins, Gene)FDA Link 01/01/2013 - "Using this device, we investigated the effects of microfluidic and nanotopographical environment on the morphology and fibrochondrogenesis of mesenchymal stem cells (MSCs) and the involvement of RhoA/ROCK pathway and Yes-associated protein (YAP)/transcriptional co-activator with PDZ-binding motif (TAZ). " 01/01/2014 - "The effect on fibrochondrogenesis was determined by comparing mRNA expression of collagen types Iα and IIα, aggrecan, and Sry-type homeobox protein-9 (SOX9) as well as protein expression of collagens I and II, glycosaminoglycan (GAG), and hydroxyproline. "
9.	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/01/2020 - "Fibrochondrogenesis is also a COL11A1 related disorder, but here disease-associated variants are recessive and may be either null alleles or substitutions of glycine, and the condition is usually lethal in infancy. " 11/12/2010 - "Sequence analysis of COL11A1 in two genetically independent fibrochondrogenesis cases demonstrated that each was a compound heterozygote for a loss-of-function mutation on one allele and a mutation predicting substitution for a conserved triple-helical glycine residue on the other. "
10.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/01/2016 - "Therefore we proposed that the stimulation of BMP-2 and VEGF by Mg ions was responsible for the fibrochondrogenesis of Mg materials. "