Alginates

Salts and esters of ALGINIC ACID that are used as HYDROGELS; DENTAL IMPRESSION MATERIALS, and as absorbent materials for surgical dressings (BANDAGES, HYDROCOLLOID). They are also used to manufacture MICROSPHERES and NANOPARTICLES for DIAGNOSTIC REAGENT KITS and DRUG DELIVERY SYSTEMS.

Also Known As:

Alginate; Alginic Acid, Barium Salt; Alginic Acid, Calcium Salt; Alginic Acid, Copper Salt; Alginic Acid, Potassium Salt; Alginic Acid, Sodium Salt; Alloid G; Barium Alginate; Calcium Alginate; Calginat; Copper Alginate; Kalrostat; Kalrostat 2; Kaltostat; Potassium Alginate; Sodium Alginate; Sodium Calcium Alginate; Vocoloid; Xantalgin; poly(Mannuronic Acid), Sodium Salt; Alginate, Barium; Alginate, Calcium; Alginate, Copper; Alginate, Potassium; Alginate, Sodium; Alginate, Sodium Calcium; Calcium Alginate, Sodium

Networked: 3209 relevant articles (263 outcomes, 580 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Alginates: 3209

Experts

1.	Høiby, Niels: 16 articles (01/2018 - 08/2002)
2.	Mooney, David J: 14 articles (01/2021 - 05/2005)
3.	Zhao, Xia: 13 articles (11/2020 - 06/2003)
4.	Cohen, Smadar: 12 articles (01/2021 - 11/2002)
5.	Ohman, Dennis E: 12 articles (05/2015 - 06/2002)
6.	Liu, Yang: 10 articles (02/2022 - 08/2013)
7.	Yu, Hongwei D: 10 articles (01/2020 - 05/2007)
8.	Wang, Wei: 10 articles (01/2019 - 07/2005)
9.	Yang, Li: 10 articles (10/2016 - 06/2003)
10.	Ng, Shiow-Fern: 9 articles (02/2021 - 09/2012)

Related Diseases

1.	Wounds and Injuries (Trauma) 08/01/2004 - "Foam and alginate dressings are highly absorbent and effective for heavily exuding wounds. " 05/14/1998 - "Alginates are a very cost-effective treatment option for flat and cavity wounds of this type." 04/04/2023 - "Numerous studies indicate that alginate applied in wound care can be enhanced with the incorporation of nanoparticles, revealing additional properties beneficial in the healing process. " 12/01/2020 - "Therefore, the present study suggests that clinicians could consider the calcium alginate gel dressing and homogenous PRP gel dressing as beneficial for wound care." 11/01/1992 - "Alginates were shown to be effective in a wide variety of acute and chronic wounds. "
2.	Gastroesophageal Reflux (GERD) 01/01/2019 - "A reflux blocking alginate taken on demand is an effective and safe option for the treatment of breakthrough symptoms in GERD patients on PPI. " 11/01/2010 - "Na alginate treatment for gastroesophageal reflux disease in preterm infants seems to be safe and effective." 02/01/2011 - "Gastro-oesophageal reflux is common in preterm newborns; at present, no studies have evaluated the efficacy of sodium alginate in this population. " 11/01/2020 - "We performed a systematic review and meta-analysis to summarize data from recent randomized controlled trials (RCTs) comparing the efficacy and safety of alginate-based formulation with PPIs or control for the treatment of GERD. " 11/01/2020 - "Efficacy and safety of alginate formulations in patients with gastroesophageal reflux disease: a systematic review and meta-analysis of randomized controlled trials."
3.	Neoplasms (Cancer) 10/05/2016 - "T-NPs dramatically disrupted the tube formation of primary human umbilical vein endothelial cells (HUVECs) and displayed improved antiangiogenic activity in the transgenic zebrafish model and the alginate-encapsulated tumor cell model. " 11/01/2019 - "In this study, we hypothesized that the on-demand release of anticancer drugs could be achieved with a macroporous alginate ferrogel under the influence of magnetic stimulation to enhance therapeutic efficacy in a tumor-bearing mouse model. " 11/01/2019 - "The therapeutic efficacy of DOX-releasing macroporous alginate ferrogel also increased in tumor-bearing mice following magnetic stimulation. " 01/01/2017 - "The objective of this study was to determine the efficacy of alginate staple-line reinforcement of fissure openings as compared with stapling alone, with or without tissue sealant or glue, in reducing the incidence and duration of air leakage after pulmonary lobectomy for malignancy. " 03/01/2010 - "Improved multimodality imaging using alginate molding in xenograft tumor models."
4.	Infections 12/01/2014 - "We conclude that the amount of evidence for recommending NPWT alone as the first-line treatment for Szilagyi grade III peripheral vascular graft infection is small with only one small-sized randomized controlled trial demonstrating that NPWT alone is superior to alginate dressing change in shortening the time to complete wound healing by 2 months. " 01/01/2021 - "Efficacy of Salmonella Bacteriophage S1 Delivered and Released by Alginate Beads in a Chicken Model of Infection." 01/01/2021 - "The safety and efficacy of BCG encapsulated alginate particle (BEAP) against M.tb H37Rv infection in Macaca mulatta : A pilot study." 04/01/1985 - "Thus antibody to alginate may offer strain-dependent protection against chronic lung infection with P. " 01/01/2017 - "In this study a strain of Pseudomonas aeruginosa (DWW2) of the mucoid alginate overproducing phenotype associated with chronic CF airway infection and a strain of the oral commensal AGS species Streptococcus anginosus (3a) from CF sputum were investigated for their ability to co-exist and their responses to biofilm co-culture. "
5.	Inflammation (Inflammations) 12/01/2020 - "Alginate partially decreased laryngeal inflammation (wet weight and not MPO) and dramatically improved laryngeal mucosal integrity. " 08/15/2019 - "The results showed that the topical application of alginate micro/nanofibrous dressings loaded with PHBE on UV-inflamed skin significantly attenuated inflammation damage, reducing the healing period. " 11/01/2018 - "Vascularization occurs within all the formulations studied and is significantly higher in SLG+MS and HApN+RCP-MS than in SLM+RCP-MS. Inflammation (based on macrophage subset staining) decreases over time in both alginate groups, but increases in the HApN+RCP-MS condition. " 09/01/2018 - "Therefore, alginate materials, especially in particulate form, have the potential to be applied in inflammation related diseases." 12/01/2015 - "Microencapsulation of mesenchymal stem cells (MSC) in alginate facilitates cell delivery, localization and survival, and modulates inflammation in vivo. "

Related Drugs and Biologics

1.	Chitosan
2.	Hydrogels
3.	Silver
4.	sodium bicarbonate drug combination magnesium trisilicate aluminium hydroxide alginate (Gaviscon)
5.	Antacids
6.	Capsules (Microcapsules)
7.	Colloids (Colloid)
8.	Gelatin
9.	Anti-Bacterial Agents (Antibiotics)
10.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Therapeutics
2.	Microspheres (Microsphere)
3.	Injections
4.	Hydrocolloid Bandages (Duoderm)
5.	Transplantation