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SR 3335

a retinoic acid receptor-related receptor alpha (RORalpha) inverse agonist; structure in first source

Also Known As:

ML 176; ML-176; ML176 cpd; SR-3335; SR3335

Networked: 7 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - SR 3335: 7
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - SR 3335: 7
  - Thiophenes: 257
    - SR 3335: 7
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - SR 3335: 7

Experts

1.	Antoine, Bénédicte: 1 article (01/2021)
2.	Auclair, Martine: 1 article (01/2021)
3.	Bahtiar, Anton: 1 article (01/2021)
4.	Capel, Emilie: 1 article (01/2021)
5.	Fujio, Yasushi: 1 article (01/2021)
6.	Fève, Bruno: 1 article (01/2021)
7.	Kametani, Yusuke: 1 article (01/2021)
8.	Kobayashi, Arisa: 1 article (01/2021)
9.	Maeda, Makiko: 1 article (01/2021)
10.	Matsumoto, Kotaro: 1 article (01/2021)

Related Diseases

1.	Ischemia 02/29/2008 - "The increase in BNP was significantly greater in the 65 patients with than in the 76 patients without ischemia [14.7 pg/ml (5.7-19.6) vs. 4.9 pg/ml (2.1-9.2), p<0.0001]; there was no difference in increase of ANP [340 pg/ml (176-729) vs. 424 pg/ml (249-648), p=0.54]. "
2.	Infections 12/01/2017 - "In this study, a role of group 2 innate lymphoid cells (ILC2) and effects of N-{4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}-2-thiophenesulfonamide (SR3335) on the host antibacterial resistance against infectious complications caused by Enterococcus faecalis oral infection were investigated in burned mice. " 12/01/2017 - "faecalis infection (5 × 106 CFU/mouse), whereas 100% of the same mice treated with SR3335 survived. " 12/01/2017 - "faecalis oral infection was amazingly mitigated in these mice after treatment with SR3335, an inhibitor of cellular differentiation from an ILC precursor (ILCP) to ILC2."
3.	Diabetic Cardiomyopathies 04/01/2017 - "Consistent with genetic manipulation, pharmacological activation of RORα by melatonin and SR1078 (a synthetic agonist) showed beneficial effects against diabetic cardiomyopathy, while the RORα inhibitor SR3335 significantly exacerbated cardiac impairments in diabetic mice. "
4.	Obesity 03/18/2011 - "We assess the ability of SR3335 to suppress gluconeogenesis in vivo using a diet-induced obesity (DIO) mouse model where the mice where treated with 15 mg/kg b.i.d., ip for 6 days followed by a pyruvate tolerance test. "
5.	Metaplasia 01/01/2017 - "SR3335 also attenuated lung mRNA expression of IL-13, Muc5ac, and Gob5 as well as mucous metaplasia. "

Related Drugs and Biologics

1.	Atrial Natriuretic Factor (ANF)
2.	SR 1078
3.	Pyruvic Acid (Pyruvate)
4.	Interleukin-13
5.	Tretinoin (Retinoic Acid)
6.	Messenger RNA (mRNA)
7.	Melatonin

Related Therapies and Procedures

1.	Aftercare (After-Treatment)