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Tretinoin (Retinoic Acid)

An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).

Also Known As:

Retinoic Acid; all-trans-Retinoic Acid; Retin-A; Vitamin A Acid; Vesanoid; Tretinoin Potassium Salt; Tretinoin Sodium Salt; Tretinoin Zinc Salt; beta-all-trans-Retinoic Acid; trans-Retinoic Acid; Acid, Retinoic; Acid, Vitamin A; Acid, all-trans-Retinoic; Acid, beta-all-trans-Retinoic; Acid, trans-Retinoic; Potassium Salt, Tretinoin; Retin A; Salt, Tretinoin Potassium; Salt, Tretinoin Sodium; Salt, Tretinoin Zinc; Sodium Salt, Tretinoin; Zinc Salt, Tretinoin; all trans Retinoic Acid; beta all trans Retinoic Acid; trans Retinoic Acid

Networked: 8030 relevant articles (594 outcomes, 952 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Lo-Coco, Francesco: 33 articles (12/2015 - 10/2002)
2.	Sanz, Miguel A: 32 articles (11/2015 - 02/2004)
3.	Tallman, Martin S: 27 articles (11/2015 - 10/2002)
4.	Yen, Andrew: 26 articles (08/2015 - 05/2002)
5.	Imaizumi, Tadaatsu: 21 articles (11/2015 - 08/2004)
6.	Chen, Zhu: 20 articles (06/2015 - 02/2002)
7.	Fujita, Takashi: 20 articles (06/2014 - 09/2005)
8.	Akira, Shizuo: 19 articles (04/2014 - 09/2005)
9.	Chomienne, C: 18 articles (12/2015 - 06/2000)
10.	Montesinos, Pau: 18 articles (05/2014 - 01/2007)

Related Diseases

1.	Acute Promyelocytic Leukemia 12/01/2015 - "Although differentiation therapy with all-trans retinoic acid (ATRA) induces complete remission in most acute promyelocytic leukemia (APL) patients, it is associated with organ toxicity. " 04/01/2014 - "The best characterized clinical application of differentiation therapy is the use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia (APL), which markedly improved the outcome of this disease. " 07/01/2013 - "All-trans retinoic acid (ATRA) induces clinical remission in most acute promyelocytic leukemia (APL) patients by inducing terminal differentiation of APL cells toward mature granulocytes. " 09/01/2011 - "All-trans retinoic acid (ATRA) induces complete remission in most cases of acute promyelocytic leukemia. " 07/01/2005 - "The success of all-trans retinoic acid in the treatment of acute promyelocytic leukemia indicates that transcription therapy can be highly effective and safe. "
2.	Acne Vulgaris 04/01/2014 - "While tretinoin has demonstrated proven efficacy in the treatment of acne lesions, it also is associated with the potential for skin irritation. " 02/01/1998 - "Topical tretinoin is effective treatment for both acne and photoaging. " 10/01/1986 - "It was reported in 1969 that topical tretinoin was effective in acne vulgaris, principally by preventing and dislodging comedones. " 06/01/2012 - "A blinded, randomized, split-face study was conducted to evaluate and compare the tolerability and efficacy of the novel anti-acne/ anti-aging product in subjects with photodamaged skin and acne vulgaris relative to tretinoin cream 0.025% (Treatment B). " 07/01/2004 - "Improved efficacy and tolerability of retinoic acid in acne vulgaris: a new topical formulation with cyclodextrin complex psi."
3.	Neoplasms (Cancer) 08/01/2003 - "In vivo administration of all-trans-retinoic acid (ATRA) dramatically reduced the presence of ImCs in all tested tumor models. " 09/01/1996 - "Many studies have shown that all trans retinoic acid (RA) exhibits significant protective effects against mouse skin tumor promotion and spontaneous as well as enhanced malignant conversion. " 09/15/2003 - "Although high concentrations (1-10 microM) of retinoic acid derivatives are generally needed for significant antitumor effects in many cancer cells, we observed that pharmacologically relevant concentrations of ATRA were effective in inducing cell death in human MB cells. " 04/15/1994 - "Elevated plasma lipid peroxide content correlates with rapid plasma clearance of all-trans-retinoic acid in patients with advanced cancer." 06/28/2012 - "All-trans retinoic acid (ATRA) is a promising therapeutic agent, but exhibits low efficacy against human cancers. "
4.	Leukemia 01/01/2002 - "All-trans retinoic acid as a single agent induces complete remission in a patient with acute leukemia of M2a subtype." 07/15/1997 - "All-trans retinoic acid (ATRA) has been used for APL patients as a potent therapeutic agent to induce differentiation of leukemia cells. " 10/01/1995 - "Despite these findings the patient obtained a complete morphological and cytogenetic remission of the leukemia following treatment with all-trans-retinoic acid. " 03/01/1995 - "Aucte promyelocytic leukemia (APL) can be treated by all-trans retinoic acid (ATRA) with high complete remission rate. " 11/01/2000 - "Retinoic acid has proved to be an effective treatment for promyelocytic leukemia. "
5.	Melanosis (Freckles) 01/01/2010 - "In both studies by other objective measures tretinoin treatment significantly reduced the severity of melasma.Thiospot" 10/01/1993 - "Topical 0.1% tretinoin produces significant clinical improvement of melasma, mainly due to reduction in epidermal pigment, but improvement is slow." 05/01/2004 - "In a recent trial, 1% tretinoin peel has shown good clinical and histologic results after biweekly applications in 2.5 weeks only in the treatment of melasma. " 06/01/1994 - "This controlled study demonstrates that topical 0.1% tretinoin lightens melasma in black patients, with only mild side effects." 12/01/2011 - "The efficiency of Tretinoin 1% peelings in declining the MASI score (treatment of melasma) was similar to GA 70%, as well as the rare unwanted complications of them. "

Related Drugs and Biologics

1.	arsenic trioxide (Trisenox)
2.	Tretinoin (Retinoic Acid)
3.	hydroquinone (Black and White)
4.	retinoic acid receptor alpha
5.	Retinoids
6.	Vitamin A (Retinol)
7.	clindamycin-2-phosphate (Clindets)
8.	Benzoyl Peroxide
9.	Aligeron (AS 2)
10.	promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Microspheres (Microsphere)
3.	Aftercare (After-Treatment)
4.	Remission Induction
5.	Chemoprevention