Pyruvic Acid (Pyruvate)

An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)

Also Known As:

Networked: 2990 relevant articles (111 outcomes, 260 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lin, Mao-Tsun: 21 articles (08/2013 - 09/2003)
2.	Vigneron, Daniel B: 20 articles (02/2014 - 10/2008)
3.	Mallet, Robert T: 17 articles (12/2015 - 04/2003)
4.	Larson, Peder E Z: 16 articles (02/2014 - 02/2010)
5.	Kurhanewicz, John: 15 articles (10/2015 - 10/2008)
6.	Nelson, Sarah J: 14 articles (12/2014 - 10/2008)
7.	Sun, Jie: 11 articles (02/2014 - 04/2003)
8.	Chen, Albert P: 10 articles (02/2014 - 10/2008)
9.	Alam, Hasan B: 10 articles (12/2013 - 08/2003)
10.	Kettunen, Mikko I: 10 articles (11/2013 - 11/2007)

Related Diseases

1.	Ischemia 11/01/1999 - "Hearts subjected to this ischemia and pretreated with pyruvate showed a significant improvement in the function recovery. " 07/01/1998 - "Pyruvate improved recovery of function after ischemia reperfusion. " 10/01/2012 - "Metabolism of hyperpolarized [1-¹³C]pyruvate in the isolated perfused rat lung - an ischemia study." 04/01/2007 - "In the present study, we investigated the possible neuroprotective effect of pyruvate in focal ischemia. " 01/01/2003 - "Aiming to study the effect of pyruvate on cardiac mitochondrial function during acute ischemia, we used an ex-vivo animal model, perfused in a Langendorff system and then subjected to ischemia in the presence and absence of pyruvate. "
2.	Neoplasms (Cancer) 11/15/2015 - "Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors." 02/01/2012 - "Experiments following injection of hyperpolarized [1-(13)C] -pyruvate in murine transgenic cancer models have shown improved delineation for tumors since signals from metabolites within tumor tissues are retained while those from the vasculature are suppressed by the diffusion preparation scheme." 11/15/2015 - "In this study, we show that metabolic MRI with hyperpolarized pyruvate is biased by tumor perfusion and present a new pharmacokinetic model for hyperpolarized substrates that accounts for these effects. " 11/06/2014 - "Three studies published in this month's Molecular Cell provide novel insights into the role of mitochondrial pyruvate in tumor metabolism and describe how targeting pyruvate transport and metabolism may afford therapeutic benefit. " 03/01/2012 - "Dynamic contrast-enhanced-MRI studies showed that, at the dose of pyruvate used, no changes in tumor perfusion were noticed. "
3.	Hemorrhagic Shock 10/01/2002 - "These beneficial findings indicate that pyruvate infused 30 min after the onset of severe hemorrhagic shock is effective in maintaining the redox environment, preventing the loss of the key antioxidant GSH, and decreasing early apoptosis indicators." 07/01/2015 - "Pyruvate dose response studies targeting the vital signs following hemorrhagic shock." 01/01/2013 - "During hemorrhagic shock the skeletal muscle response was characterized by a lack of increase in pyruvate and higher L:P ratios. " 07/01/2005 - "Pyruvate modulates hepatic mitochondrial functions and reduces apoptosis indicators during hemorrhagic shock in rats." 10/01/2002 - "Pyruvate improves redox status and decreases indicators of hepatic apoptosis during hemorrhagic shock in swine."
4.	Anoxia (Hypoxia) 05/01/2011 - "Pyruvate evoked a hypoxia-like response under normoxic conditions and was retina-protective against strong white light. " 05/01/2013 - "Inducible deletion of exon 1 of the Hif1a gene improved the ability of NSPCs to utilize pyruvate during glycolytic inhibition, but did not alter other parameters of metabolism, including their ability to withstand prolonged hypoxia. " 10/01/2007 - "In this study, we showed that cells had a greater need for pyruvate during hypoxia. " 11/03/2015 - "We demonstrate that this hypoxia-suppressed miR-199a plays a decisive role in limiting glycolysis in HCC cells by targeting hexokinase-2 (Hk2) and pyruvate kinase-M2 (Pkm2). " 09/01/2015 - "Measurement of the acute metabolic response to hypoxia in rat tumours in vivo using magnetic resonance spectroscopy and hyperpolarised pyruvate."
5.	Body Weight (Weight, Body) 01/01/2014 - "The objective of this systematic review was to examine the efficacy of pyruvate in reducing body weight. " 01/01/2014 - "The evidence from randomized clinical trials does not convincingly show that pyruvate is efficacious in reducing body weight. " 01/01/2014 - "The meta-analysis revealed a statistically significant difference in body weight with pyruvate compared to placebo (MD: -0.72 kg; 95% CI: -1.24 to -0.20). " 05/01/1999 - "Thus, the ingestion of 6 g of pyruvate for 6 wk, in conjunction with mild physical activity, resulted in a significant decrease in body weight and fat mass." 05/01/1999 - "After 6 wk of treatment, there was a statistically significant decrease in body weight (-1.2 kg, P<0.001), body fat (-2.5 kg, P<0.001), and percent body fat (23.0% pre versus 20.3% 6 wk post) in the pyruvate group. "

Related Drugs and Biologics

1.	Lactic Acid
2.	Glucose (Dextrose)
3.	Sodium
4.	Adenosine Triphosphate (ATP)
5.	Glutamic Acid (Glutamate)
6.	Oxaloacetate
7.	Oxidoreductases
8.	ethyl pyruvate
9.	Dichloroacetate (Dichloroacetic Acid)
10.	Oxygen

Related Therapies and Procedures

1.	Resuscitation
2.	Ligation
3.	Oral Administration
4.	Ketogenic Diet
5.	Fluid Therapy (Oral Rehydration Therapy)