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SR 1078

a RORalpha and RORgamma agonist; structure in first source

Also Known As:

N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide; SR-1078; SR1078

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Burris, Thomas P: 3 articles (01/2021 - 01/2012)
2.	Wang, Yongjun: 2 articles (02/2016 - 01/2012)
3.	Gao, Pingming: 1 article (01/2022)
4.	Li, Huilin: 1 article (01/2022)
5.	Li, Ling: 1 article (01/2022)
6.	Song, Yuan: 1 article (01/2022)
7.	Wang, Min: 1 article (01/2022)
8.	Xiao, Li: 1 article (01/2022)
9.	Yao, Paul: 1 article (01/2022)
10.	Yu, Hong: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2012 - "We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. " 01/01/2021 - "Reestablishment of the activity of the clock activator RORα via its genetic overexpression and its stimulation through the agonist SR1078, restores BMAL1 expression and oscillation, effectively blocks MYCN-mediated tumor growth and de novo lipogenesis, and sensitizes NB tumors to conventional chemotherapy. "
2.	Inflammation (Inflammations) 09/01/2015 - "SR1078 reversed the protective effect of JQ-1 on skin inflammation at both histological and molecular levels in the IMQ model. " 09/01/2015 - "Additionally, a RORα/γ agonist SR1078 was utilized to investigate the role of RORC in BET-mediated skin inflammation. " 01/01/2022 - "Our results showed that SOD mimetic MnTBAP completely, while RORA agonist SR1078 partly, reversed maternal diabetes-mediated oxidative stress and inflammation in the brain, PBMC and IEC, as well as GI symptoms, including intestine permeability and altered gut microbiota compositions. "
3.	Diabetic Cardiomyopathies 04/01/2017 - "Consistent with genetic manipulation, pharmacological activation of RORα by melatonin and SR1078 (a synthetic agonist) showed beneficial effects against diabetic cardiomyopathy, while the RORα inhibitor SR3335 significantly exacerbated cardiac impairments in diabetic mice. "
4.	Neuroblastoma 02/17/2016 - "Furthermore, these mice display increased expression of ASD-associated RORα target genes in both the brains of the BTBR mice and in a human neuroblastoma cell line treated with SR1078. "
5.	Hepatocellular Carcinoma (Hepatoma) 03/01/2015 - "Adenovirus (Ad)-mediated overexpression of RORα (Ad-RORα) or treatment with the RORα activator, SR1078, reduced aerobic glycolysis and down-regulated biosynthetic pathways in hepatoma cells. "

Related Drugs and Biologics

1.	SR 3335
2.	Melatonin
3.	manganese(III)-tetrakis(4-benzoic acid)porphyrin

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)