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L-Ala-gamma-D-Glu-meso-diaminopimelic acid

a natural proinflammatory bacterial tripeptide peptide released during peptidoglycan degradation

Also Known As:

Tri-DAP

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Pimelic Acids: 3
        Diaminopimelic Acid: 36
        L-Ala-gamma-D-Glu-meso-diaminopimelic acid: 6
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - L-Ala-gamma-D-Glu-meso-diaminopimelic acid: 6
- Amino Acids: 30675
  - Diamino Amino Acids: 101
    - Diaminopimelic Acid: 36
      - L-Ala-gamma-D-Glu-meso-diaminopimelic acid: 6

Experts

1.	Girardin, Stephen E: 2 articles (11/2005 - 10/2005)
2.	Jéhanno, Muguette: 2 articles (11/2005 - 10/2005)
3.	Mengin-Lecreulx, Dominique: 2 articles (11/2005 - 10/2005)
4.	Philpott, Dana J: 2 articles (11/2005 - 10/2005)
5.	Sansonetti, Philippe J: 2 articles (11/2005 - 10/2005)
6.	Bruchhage, Karl-Ludwig: 1 article (01/2022)
7.	Draf, Clara Sophia: 1 article (01/2022)
8.	Därr, Markus: 1 article (01/2022)
9.	Kurabi, Arwa: 1 article (01/2022)
10.	Leffers, David: 1 article (01/2022)

Related Diseases

1.	Bacterial Infections (Bacterial Infection) 01/01/2022 - "The influence of bacterial infection on immunomodulating molecules (TNFα, MDP, Tri-DAP, SB203580, Cycloheximide) in HMEEC was evaluated. " 11/18/2005 - "Nod1 is an intracellular pattern recognition molecule activated following bacterial infection, which senses a specific muropeptide (l-Ala-d-Glu-meso-DAP (diaminopimelic acid); "Tri(DAP)") from peptidoglycan. "
2.	Necrosis 10/01/2014 - "The level of cytokines [interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α)] and chemokines (CXCL1 and CCL2) was increased by MDP, but not Tri-DAP in wild-type (WT) neutrophils. "
3.	Inflammation (Inflammations) 09/01/2010 - "Given that PepT1 is highly expressed in the colon during inflammation, PepT1-mediated Tri-DAP transport may occur more effectively during such conditions, further contributing to intestinal inflammation." 09/01/2010 - "Colonic epithelial HT29-Cl.19A cells, which do not express PepT1 under basal condition, were mostly insensitive to Tri-DAP-induced inflammation. "
4.	Infections 09/25/2014 - "Cells were infected with Mtb and treated with Tri-DAP post-infection. "
5.	Crohn Disease (Crohn's Disease) 10/28/2005 - "Together, our results identified a cross-talk between the Nod1 and Nod2 pathways and suggested that down-regulation of Nod1/M-Tri(DAP) pathway may be associated with Crohn disease."

Related Drugs and Biologics

1.	Chemokines
2.	Cytokines
3.	Interleukin-6 (Interleukin 6)
4.	Peptidoglycan (Murein)
5.	Diaminopimelic Acid
6.	Cycloheximide (Cicloheximide)
7.	SB 203580