Cycloheximide (Cicloheximide)

01/01/1978 - "Studies on memory: spontaneous return of memory in 6-hydroxydopamine-treated mice and its relation to cycloheximide-induced transient amnesia."
01/01/2020 - "We investigated whether cycloheximide (CHX) would induce amnesia for the stress-induced impairment of extinction retrieval. "
05/01/2019 - "Cycloheximide injection and reminder in 10 days after induction of amnesia did not affect its development or caused a transient memory recovery (2 days). "
11/01/2017 - "Cycloheximide injection during training or memory reconsolidation in trained snails produced amnesia. "
09/01/2012 - "In mice, amnesia was induced by intraperitoneal cycloheximide (100 mg/kg) administration 20 min before exposure to tone signal combined with footshock (2 sec, 0.5 mA). "

11/30/2007 - "In our previous study, we found that cycloheximide (CHX) induces hepatocellular necrosis as well as hepatocellular apoptosis. "
03/12/2022 - "In vitro, treatment with tumour necrosis factor-α (TNF-α) plus cycloheximide (CHX) or SLE sera induced HK2 cells to undergo pyroptosis in a caspase-3- and GSDME-dependent manner. "
01/01/2015 - "The results showed that the numbers of microparticles were increased by tumour necrosis factor (TNF) or the combination of TNF and cycloheximide (CHX). "
01/01/2013 - "However, in the presence of cycloheximide or SMAC mimetics, programmed necrosis was only moderately reduced in CYLD(-/-) cells. "
02/01/2012 - "In cultured human proximal tubule (HK-2) cells, the S1P(2)R antagonist selectively upregulated SK1 and attenuated both H(2)O(2)-induced necrosis and TNF-α/cycloheximide-induced apoptosis; the S1P(2)R agonist had the opposite effects. "

12/01/2007 - "This study investigated the effects of serum starvation and cycloheximide (CHX) on the cell cycle of low (5th) and high (15th) passages fetal porcine fibroblasts. "
05/31/2012 - "The presence of 2% PRP significantly inhibited serum starvation- or TNF-α/cycloheximide-induced apoptosis in comparison to 2% FBS or 2% PPP. "
01/01/2003 - "Neither cycloheximide nor starvation had any effect on the induction of apoptosis by GGO. "
03/01/1998 - "Additional results of Zetterberg and Larsson--1) cycloheximide treatment affects cells in the same way as low serum, and 2) a delay in the second division after serum starvation in the cells not initially affected in their first division--indicate that their experiments are consistent with serum removal affecting cells in all phases of the cell cycle equally. "
01/01/1990 - "Both transcripts are also accumulated after exposure to low cycloheximide doses or nutrient starvation. "

01/01/2017 - "Expression of SRSF5 as well as CIRP and RBM3 were also induced by DNA damage, hypoxia, cycloheximide and hypotonicity. "
01/01/2012 - "RT-PCR and cycloheximide inhibition experiments indicated that PMS-induced HIF-1α decrease is involved in post-translational degradation during hypoxia. "
10/01/2007 - "Cycloheximide did not block the effect of hypoxia on D2 activity and D2 half-life was enhanced under hypoxia demonstrating a posttranslational action of hypoxia. "
12/10/1999 - "Addition of cycloheximide diminished the viability of astrocytes in hypoxia, suggesting an obligatory role of de-novo gene expression to respond to hypoxia. "
03/16/1998 - "The presence of cycloheximide during hypoxia inhibited both peaks of synthesis and prevented the development of apoptosis. "

09/01/1998 - "Cycloheximide eliminated ischemic PC-induced IT effects on both brain injury and neurological deficits if administered before PC (P<0.05) but not if administered long after PC but before PMCAO. "
01/01/2013 - "Cycloheximide also protected neurons from hypoxic cell death, indicating that translational inhibitors may generally reduce secondary brain injury. "
06/01/2006 - "Therapeutic window for cycloheximide treatment after hypoxic-ischemic brain injury in neonatal rats."
02/01/1997 - "Cycloheximide reduces the size of lesion caused in rats by a photothrombotic model of brain injury."
02/01/1997 - "In line with previous reports in which we described the occurrence of apoptosis in the model of photothrombotic brain injury our results with cycloheximide suggest that this model of focal brain ischemia can be used to test the neuroprotective efficacy of putative antiapoptotic compounds."