ginkgolide B

02/01/2011 - "Ginkgolide B complex efficacy for brief prophylaxis of migraine in school-aged children: an open-label study."
02/01/2011 - "Ginkgolide B, a herbal constituent extract from Ginkgo biloba tree leaves, was considered as a promising pharmacological aid for the treatment of migraine in adult patients because of its modulation of the glutamatergic transmission in the CNS and on antiplatelet activating factor (PAF). "
06/01/2010 - "Finally, ginkgolide B has proved significantly effective in controlling migraine with aura and pediatric migraine in uncontrolled studies that need a confirmation."
05/01/2013 - "The efficacy of ginkgolide B in the acute treatment of migraine aura: an open preliminary trial."
06/01/2010 - "These preliminary data show that Ginkgolide B seems to be effective as preventive treatment in reducing migraine attack frequency and in attenuating the use of symptomatic medication in our small series of children with primary headache."

05/01/2009 - "Efficacy of Ginkgolide B in the prophylaxis of migraine with aura."
05/01/2009 - "In a multicentric, open, preliminary trial, we evaluated the use of ginkgolide B, a herbal constituent extract from Ginkgo biloba tree leaves, in the prophylactic treatment of migraine with aura (MA). "
06/01/2010 - "Finally, ginkgolide B has proved significantly effective in controlling migraine with aura and pediatric migraine in uncontrolled studies that need a confirmation."
05/01/2013 - "In this open trial we evaluated the possible efficacy of Ginkgolide B in the treatment of acute aura in a group of patients suffering from migraine with aura, considering in particular the effect of the treatment on aura duration. "
01/01/2015 - "Recent studies show anxiolytic properties of ginkgolide A, migraine with aura treatment by ginkgolide B, a reduction in ischemia-induced glutamate excitotoxicity by bilobalide, and an alternative antihypertensive property of quercetin, among others. "

01/31/2010 - "In conclusion, Ginkgolide B could pass through BBB, especially after ischemia-reperfusion injury of brain, and might be therapeutically effective for ischemia/reperfusion injury of human brain."
01/31/2010 - "Blood brain barrier permeability and therapeutic time window of Ginkgolide B in ischemia-reperfusion injury."
04/01/2010 - "Ginkgolide B has protective effects on cerebral injury by inhibiting the inflammation induced by ischemia/reperfusion injury."
11/20/2012 - "Inhibition of NF-κB activation is associated with anti-inflammatory and anti-apoptotic effects of Ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury."
09/01/2003 - "These observations suggest that treatment with GIK solution and BN 52021 before reperfusion and during reperfusion period may be useful in decreasing intestinal reperfusion injury."

11/01/1994 - "BN 52021 Sepsis Study Group."
11/01/1994 - "The studied platelet-activating factor receptor antagonist (BN 52021) seems to be a safe and promising treatment for patients with severe Gram-negative sepsis."
11/01/1994 - "Platelet-activating factor receptor antagonist BN 52021 in the treatment of severe sepsis: a randomized, double-blind, placebo-controlled, multicenter clinical trial. "
01/01/2004 - "Four-day administration of BN 52021 failed to demonstrate a statistically significant reduction in mortality in patients with severe sepsis suspected or confirmed to be related to infections other than Gram-positive bacterial infection."
01/01/2004 - "Efficacy and Safety of the Platelet-Activating Factor Receptor Antagonist BN 52021 (Ginkgolide B) in Patients with Severe Sepsis : A Randomised, Double-Blind, Placebo-Controlled, Multicentre Trial."

04/01/2005 - "To investigate the inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation and the possible mechanisms. "
04/01/2005 - "[Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation]."
04/01/2010 - "Ginkgolide B has protective effects on cerebral injury by inhibiting the inflammation induced by ischemia/reperfusion injury."
04/01/2010 - "To investigate the protective effects of Ginkgolide B on inflammation induced by cerebral ischemia-reperfusion in rats. "
11/01/2014 - "These results demonstrated that ginkgolide B might be a promising drug on inhibiting platelet function and reducing inflammation in atherosclerosis."