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Platelet Activating Factor

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A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.

Also Known As:

1-Alkyl-2-acetyl-sn-glycerophosphocholine; Platelet Aggregating Factor; Platelet Aggregation Enhancing Factor; Platelet-Activating Substance; Thrombocyte Aggregating Activity; 1 Alkyl 2 acetyl sn glycerophosphocholine; Aggregating Factor, Platelet; Factor, Platelet Activating; PAF Acether; Platelet Activating Substance; AGEPC; Acetyl Glyceryl Ether Phosphorylcholine; PAF-Acether; Phosphorylcholine, Acetyl Glyceryl Ether

Networked: 2613 relevant articles (62 outcomes, 265 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Antonopoulou, Smaragdi: 15 articles (10/2015 - 04/2002)
2.	Demopoulos, Constantinos A: 13 articles (09/2014 - 04/2002)
3.	Fragopoulou, Elizabeth: 12 articles (10/2015 - 04/2002)
4.	Ishii, Satoshi: 12 articles (02/2015 - 03/2002)
5.	Shimizu, Takao: 11 articles (02/2015 - 01/2002)
6.	Finkelman, Fred D: 9 articles (03/2015 - 04/2002)
7.	Travers, Jeffrey B: 9 articles (12/2014 - 05/2003)
8.	Im, Suhn-Young: 9 articles (09/2014 - 05/2006)
9.	Bazan, Nicolas G: 9 articles (03/2012 - 02/2003)
10.	Denizot, Yves: 9 articles (06/2010 - 04/2003)

Related Diseases

1.	Asthma (Bronchial Asthma) 04/01/1998 - "We conclude that SR 27417A is effective in inhibiting systemic, cellular and pulmonary effects after platelet-activating factor challenge in patients with mild bronchial asthma." 10/01/1992 - "Platelet-activating factor antagonists may partially be effective in asthma through inhibitory effects on neutrophil chemotaxis." 01/01/2008 - "Platelet-activating factor (PAF): a review of its role in asthma and clinical efficacy of PAF antagonists in the disease therapy." 09/01/1999 - "The pathogenic role of platelet-activating factor (PAF) in asthma has been questioned due to the limited or negative efficacy of PAF antagonists; however, in acute asthma (AA), where the endogenous release of PAF may be enhanced, the effects of PAF antagonist receptors have not been investigated. " 03/15/2000 - "Numerous in vitro and in vivo studies in both animal models and human asthmatics have implicated platelet-activating factor (PAF) as an important inflammatory mediator in asthma. "
2.	Anaphylaxis (Anaphylactic Shock) 08/01/1998 - "In order to find out anti-platelet activating factor (PAF) from natural resources, Korean medicinal plants used for the treatments of peripheral circulation disorders were tested for their possible protective effects on PAF-induced anaphylactic shock. " 01/01/2011 - "Mechanistic studies showed that the food allergic systemic anaphylaxis was dependent on platelets, FcRγ and mast cells, and partially dependent on platelet activating factor and monocytes/macrophages, depending on mouse strain. " 06/01/2015 - "Platelet-activating factor (PAF) is a potent phospholipid-derived mediator the central role of which has been well established in experimental models of both immune-mediated and non-immune mediated anaphylaxis. " 06/01/2015 - "Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis." 01/01/2014 - "Platelet-activating factor (PAF) is a highly potent phospholipid mediator responsible for the life-threatening manifestations of anaphylaxis. "
3.	Ischemia 04/01/2000 - "The purpose of the present study was to determine if platelet-activating factor is an important mediator that produces vasospasm during reperfusion after ischemia in skeletal muscle. " 06/01/1997 - "Platelet-activating factor expression within musculocutaneous flaps subjected to ischemia and reperfusion was non directly demonstrated in this study. " 01/01/1996 - "The purpose of this study was to evaluate the renoprotective effect of a specific platelet-activating factor antagonist (WEB-2086) in an experimental model of normothermic renal ischemia. " 03/21/1994 - "This study investigated the distribution of platelet activating factor (PAF) binding sites in the brain and their involvement in global ischemia in a model of bilateral common carotid occlusion in the gerbil. " 02/01/1993 - "This study investigated the role of platelet-activating factor in the recruitment of polymorphonuclear neutrophils (PMN) in a rabbit model of cardiac ischemia and reperfusion. "
4.	Pancreatitis 07/01/2001 - "The effect of platelet-activating factor (PAF) in the pathogenesis of acute pancreatitis has been proved in various studies. " 08/01/2000 - "To study the role of platelet activating factor (PAF) in the pathogenesis of intestinal mucosal injury and endotoxin/bacterial translocation in acute severe pancreatitis (ASP) in pigs. " 06/01/1998 - "The initial studies on the therapeutic significance of lexipanphate-antagonist of platelet activating factor (PAF) in acute pancreatitis is promising. " 07/01/1993 - "This study demonstrates the formation of platelet-activating factor (PAF) in rats with acute experimental pancreatitis (AEP). " 10/01/1992 - "This study investigates the role of platelet-activating factor (PAF) in experimental pancreatitis. "
5.	Shock 01/01/1997 - "This study aimed at evaluating the role of platelet-activating factor (PAF) on cardiovascular dysfunction in postischemic shock in pigs. " 01/01/1995 - "This study aimed at evaluating the role of platelet-activating factor (PAF) antagonism in haemorrhagic shock in juvenile pigs. " 08/01/1994 - "This study was designed to investigate the role of PAF blockade during experimental Gram-positive shock by pretreatment with platelet activating factor-antagonist (PAF-A). " 12/01/1992 - "[Experimental study on platelet activating factor and systemic circulatory failure caused by ischemic liver]." 10/01/1990 - "[An experimental study on shock after temporary hepatic inflow occlusion and platelet activating factor (PAF)]."

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	WEB 2086 (apafant)
3.	epiyangambin
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Platelet Activating Factor
6.	Antigens
7.	Arachidonic Acid (Vitamin F)
8.	TCV 309
9.	Carrageenan
10.	CV 6209

Related Therapies and Procedures

1.	Resuscitation
2.	Intravenous Injections
3.	Injections
4.	Aftercare (After-Treatment)
5.	Homologous Transplantation (Allograft)