Lactones

01/01/2015 - "After 2005, outbreaks reported at the eastern shore as well as for new infections in other areas of high infection frequency were considered to possibly be related to reduced efficacy of macrocyclic lactones. "
01/01/2013 - "Macrocyclic lactones (MLs) represent the major drug class for control of parasitic infections in humans and animals. "
06/30/2012 - "Finally, the determination of free and bound volatile compounds showed that some of them were only found in blue withered berries, δ-lactones being considered the main chemical markers of the noble rot infection that are important for the odor character. "
11/01/2011 - "With routine use of macrocyclic lactones, in some cases knowingly, in dogs with existing heartworm infections, veterinarians should recognize the benefits, and possible complications, arising from this behavior. "
01/01/2011 - "N-Acylhomoserine lactones (AHLs) are an important class of signaling molecules involved in bacterial QS and in many pathogenic bacteria infection and host colonization are AHL-dependent. "

01/01/1980 - "The cytotoxic effects of sesquiterpene gamma-lactones in tissue culture were studied on two different cell lines, one of them fibroblastoid cells L-929 from mice areolar tissue, and the other epithelial cells HEp-2 from human laryngeal carcinoma. "
05/01/1979 - "The addition of the nitrosoureas or the lactones or a combination of both produced no improvement in length of patient survival for either primary carcinoma when compared to treatment with 5-FU alone."
01/01/2012 - "Five known sesquiterpene lactones with the eudesmane skeleton have been isolated and the cytotoxic activity of these compounds was tested in vitro on A549 (human lung carcinoma epithelial-like) and V79379A (Chinese hamster lung fibroblast-like) cells using the tetrazolium salt reduction (MTT) assay. "
04/01/1986 - "Evaluation of the in vitro cytotoxicity of some sesquiterpene lactones on a human lung carcinoma cell line using the fast green dye exclusion assay."
02/01/2003 - "Compounds 1-3 showed in vitro cytotoxic activity against human cancer cell lines of malignant melanoma (SK-MEL), epidermoid (KB), ductal (BT-549) and ovarian (SK-OV-3) carcinomas with IC(50) values of 2-6 microgram/mL. In addition, 12 sesquiterpene lactones (4-15), isolated previously from the aerial parts of Vicoa pentanema, were evaluated for cytotoxic and antimicrobial activities. "

05/01/2012 - "Two preparations are currently in use for the diagnosis of allergic contact dermatitis caused by Asteraceae: (i) Sesquiterpene lactone (SL) mix [three pure sesquiterpene lactones (STLs)], whose use has been questioned, owing to an insufficient rate of true-positive results; and (ii) Compositae mix, consisting of five Asteraceae extracts, which is problematic because of lack of standardization and questionable reproducibility. "
03/01/1996 - "Sesquiterpene lactones are a large, diverse group of chemicals found in several plant families that cause allergic contact dermatitis. "
01/01/1990 - "Many sesquiterpene lactones, terpenoid compounds present in members of the Compositae (Asteraceae) family of plants, are known to cause allergic contact dermatitis. "
07/01/1985 - "Composites and some other plants containing sesquiterpene lactones, frequently cause allergic contact dermatitis in man. "
11/01/1983 - "This species of the Compositae family, native to the Caribbean region, has spread widely in India, causing allergic contact dermatitis from its content of sesquiterpene lactones, and has recently appeared in Australia. "

01/01/2006 - "In the first part of this review we discuss the biological activities of styryl lactones focusing on cancer cells, the causal agent of Chagas' disease and the vectors for yellow fever and human lymphatic filariasis. "
08/01/2010 - "The reduction of parasitism tissue upon treatment with two lignano lactones, namely (-)- cubebin (CUB) and (-)-hinokinin (HNK), was evaluated in the chronic phase of Chagas' disease by quantifying the enzyme beta-galactosidase expressed by the CL B5 clone strain of Trypanosoma cruzi. "
01/01/1999 - "cruzi and in experimental Chagas disease (murine model): alkyllysophospholipids; 5-amino-imidazole-4-carboxamides; bisbenzyl-isoquinolines; cruzipain (crucein) inhibitors; Gossipol; phenothiazines; d) drugs effective in vitro without other reported effects, acridines, actinomycin D, Crystal Violet (gentian violet), diterpenes (Mikania obtusata); N,N'-dimethyl-2-propen-1-amine, epoxidienthiol carbamates, Fe-chelators, guanyl hydrazones, o-naphthoquinones (beta-lapachone); quinoids (miconidine; tingenone); Olivacine, phenazine methosulfate, phenoxi-phenoxyl drugs, Proadifen, pyridinium azolate betaines, sesquiterpenes (Lychophora sp), sesquiterpene lactones, tetrahydrocarbazoles, DL-alpha-trifluoromethylarginine, triphenylmetane dyes. "

05/01/1979 - "The sesquiterpene lactones were marginally effective against induced pleurisy. "
05/05/2014 - "Costunolide and Dehydrocostuslactone, two natural sesquiterpene lactones, ameliorate the inflammatory process associated to experimental pleurisy in mice."