N-Me-Tyr1,D-Ala2,Asn8,Arg29-NHCH3-JI-38

a GHRH agonist

Also Known As:

MR-409

Networked: 12 relevant articles (4 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Hypothalamic Hormones: 68
      - Pituitary Hormone-Releasing Hormones: 39
        Growth Hormone-Releasing Hormone: 738
        Sermorelin: 11
        N-Me-Tyr1,D-Ala2,Asn8,Arg29-NHCH3-JI-38: 12
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Hypothalamic Hormones: 68
        Pituitary Hormone-Releasing Hormones: 39
        Growth Hormone-Releasing Hormone: 738
        Sermorelin: 11
        N-Me-Tyr1,D-Ala2,Asn8,Arg29-NHCH3-JI-38: 12
- Peptides: 82426
  - Neuropeptides: 6772
    - Hypothalamic Hormones: 68
      - Pituitary Hormone-Releasing Hormones: 39
        Growth Hormone-Releasing Hormone: 738
        Sermorelin: 11
        N-Me-Tyr1,D-Ala2,Asn8,Arg29-NHCH3-JI-38: 12
  - Peptide Hormones: 1347
    - Hypothalamic Hormones: 68
      - Pituitary Hormone-Releasing Hormones: 39
        Growth Hormone-Releasing Hormone: 738
        Sermorelin: 11
        N-Me-Tyr1,D-Ala2,Asn8,Arg29-NHCH3-JI-38: 12

Experts

1.	Schally, Andrew V: 10 articles (11/2021 - 02/2014)
2.	Cai, Renzhi: 6 articles (11/2021 - 02/2014)
3.	Sha, Wei: 5 articles (01/2021 - 02/2014)
4.	Cui, Tengjiao: 4 articles (06/2018 - 02/2014)
5.	Block, Norman L: 4 articles (12/2017 - 02/2014)
6.	Gesmundo, Iacopo: 3 articles (01/2021 - 11/2017)
7.	Granata, Riccarda: 3 articles (01/2021 - 11/2017)
8.	Zhang, Xianyang: 2 articles (11/2021 - 11/2015)
9.	Brunetti, Luigi: 2 articles (01/2021 - 01/2021)
10.	Chiavaroli, Annalisa: 2 articles (01/2021 - 01/2021)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2021 - "Thus, our findings highlight the protective effects of MIA-690 and MR-409 on inflammation stimuli. " 10/01/2023 - "Both growth hormone-releasing hormone (GHRH) and its potent agonistic analog, MR-409, exert protective effects on muscle atrophy, cardiomyopathies, ischemic stroke, and inflammation. " 01/01/2021 - "The antagonist MIA-602 reduced significantly the expression of inflammation-related genes Il1b, Il6, and Tnf Moreover, agonist MR-409 further enhanced the promotion of RGC survival by lens injury or zymosan-induced macrophage activation, whereas antagonist MIA-602 attenuated the enhancement in RGC survival. "
2.	Body Weight (Weight, Body) 10/01/2023 - "Daily subcutaneous treatment with MR-409 (1 or 2 mg/kg), from postnatal day 2 (P2) to euthanization (P12), increased body weight and improved motor behavior in SMA mice, particularly at the highest dose tested. " 01/01/2021 - "Compared to vehicle, MIA-690 increased food intake and body weight, while MR-409 had no effect. " 11/03/2015 - "The maximal therapeutic benefits with respect to the efficiency of engraftment, ability to reach normoglycemia, gain in body weight, response to high glucose challenge, and induction of higher levels of serum insulin and IGF1 were observed when diabetic mice were transplanted with rat islets preconditioned with GHRH agonist, MR-409, and received additional treatment with MR-409 posttransplantation. "
3.	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 11/03/2015 - "administration of 10 μg MR-409 for 3 wk dramatically reduced the severity of streptozotocin (STZ)-induced diabetes in nonobese diabetic severe combined immunodeficiency (NOD/SCID) mice. "
4.	Cardiomyopathies (Cardiomyopathy) 10/01/2023 - "Both growth hormone-releasing hormone (GHRH) and its potent agonistic analog, MR-409, exert protective effects on muscle atrophy, cardiomyopathies, ischemic stroke, and inflammation. "
5.	Muscular Atrophy (Muscle Atrophy) 10/01/2023 - "Both growth hormone-releasing hormone (GHRH) and its potent agonistic analog, MR-409, exert protective effects on muscle atrophy, cardiomyopathies, ischemic stroke, and inflammation. "

Related Drugs and Biologics

1.	MIA-690
2.	Streptozocin (Streptozotocin)
3.	Growth Hormone-Releasing Hormone (Somatotropin Releasing Hormone)
4.	Insulin Receptor Substrate Proteins
5.	Nitric Oxide Synthase (NO Synthase)
6.	Interleukin-6 (Interleukin 6)
7.	Zymosan
8.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
9.	Serotonin (5 Hydroxytryptamine)
10.	Messenger RNA (mRNA)