Hypothalamic Hormones

Peptide hormones produced by NEURONS of various regions in the HYPOTHALAMUS. They are released into the pituitary portal circulation to stimulate or inhibit PITUITARY GLAND functions. VASOPRESSIN and OXYTOCIN, though produced in the hypothalamus, are not included here for they are transported down the AXONS to the POSTERIOR LOBE OF PITUITARY before being released into the portal circulation.

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Networked: 55 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schally, Andrew V: 2 articles (11/2015 - 01/2005)
2.	Wysokiński, Adam: 2 articles (04/2015 - 01/2015)
3.	Rick, Ferenc G: 1 article (11/2015)
4.	Block, Norman L: 1 article (11/2015)
5.	Kaźmierski, Jakub: 1 article (04/2015)
6.	Kłoszewska, Iwona: 1 article (04/2015)
7.	Haskett, Roger F: 1 article (06/2014)
8.	Mohan, Subburaman: 1 article (01/2014)
9.	Yu, Hongrun: 1 article (01/2014)
10.	Watt, Heather: 1 article (01/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1984 - "New approaches to the therapy for some endocrine-dependent tumors with analogs of hypothalamic hormones are being developed on the basis of experimental studies in animal models. " 01/01/2005 - "[From the discovery of hypothalamic hormones to the development of analogues as anti-cancer agents]." 10/01/2001 - "Human tumors producing hypothalamic hormones are also discussed. " 10/01/2001 - "Hypothalamic hormones and cancer." 04/01/1994 - "Hypothalamic hormones: from neuroendocrinology to cancer therapy."
2.	Thymus Neoplasms (Thymus Neoplasm) 09/01/1979 - "In the thymic tumor cells, norepinephrine, serotonin, and TRH were found to be effective in increasing ACTH secretion and intracellular cAMP levels, whereas biogenic amines, hypothalamic hormones, and gastrointestinal hormones did not affect hormone secretion in the thyroid tumor cells. "
3.	Carcinoma (Carcinomatosis) 03/01/1989 - "The feasibility of applying this treatment with analogs of hypothalamic hormones to human pancreatic carcinoma can be envisioned from these studies." 01/01/1984 - "Inhibition of growth of pancreatic carcinomas in animal models by analogs of hypothalamic hormones."
4.	Pituitary Neoplasms (Pituitary Adenoma) 08/01/2009 - "Meanwhile, the role of hypothalamic hormones in the development of pituitary adenomas has recently attracted the attention of investigators. " 10/01/1993 - "Alterations in receptor and signal transduction mechanisms in pituitary tumors triggered by hypothalamic hormones may result in amplification of stimulatory inputs and impairment of inhibitory inputs." 06/01/1991 - "The role of hypothalamic hormones in the pathogenesis of pituitary adenomas." 06/01/1991 - "A role for hypothalamic hormones in the development and growth of pituitary tumors has also been suggested by the association of pituitary adenomas with tumors producing hypothalamic hormones. " 06/01/1991 - "There is evidence that hypothalamic hormones can regulate hormone secretion by pituitary adenomas. "
5.	Adenoma (Adenomas) 03/01/1994 - "While multiple lines of evidence suggest an intrinsic somatic cell defect in adenoma formation, the role of hypothalamic hormones in pituitary tumorigenesis remains unclear. " 10/01/1985 - "During the postoperative observation period, their basal growth hormone levels remained normal as did their responses to provocation with hypothalamic hormones, confirming that the adenoma had been completely resected. " 08/01/2009 - "This finding indicates that the endogenous expression of hypothalamic hormones and their receptors in human pituitary adenoma cells has ample significance in the autocrine or paracrine regulation of pituitary hormone production and tumor extension induced by hypothalamic hormones produced by adenoma cells. " 11/01/1990 - "The coproduction of the unusual combination of two hormones such as GH and alpha-subunit in a single-type of adenoma cell and the coexistence of thyrotrophs and somatotrophs in one pituitary adenoma along with the aberrant responses of TSH beta, alpha-subunit, and GH to multiple hypothalamic hormones suggest the dedifferentiation of pituitary cells to multipotential progenitor cells by neoplastic transformation." 09/01/2004 - "Twenty-one consecutive patients with a unilateral incidentaloma, the biochemical features of subclinical cortisol hypersecretion and/or the scintigraphic features of an autonomously functioning adrenal adenoma were investigated for plasma cortisol responses to various stimuli: upright posture, meal, combined hypothalamic-hormones, the vasopressin analogue terlipressin, glucagon, angiotensin II, the serotonin 5-HT4 agonist cisapride, and ACTH. "

Related Drugs and Biologics

1.	Growth Hormone (Somatotropin)
2.	Hormones
3.	Adrenocorticotropic Hormone (ACTH)
4.	Serotonin (5 Hydroxytryptamine)
5.	Norepinephrine (Noradrenaline)
6.	Gastrointestinal Hormones (Hormones, Gastrointestinal)
7.	Biogenic Amines (Biogenic Amine)
8.	Gonadotropin-Releasing Hormone (GnRH)
9.	Cytokines
10.	Pituitary Hormones

Related Therapies and Procedures

1.	Immunotherapy
2.	Renal Dialysis (Hemodialysis)
3.	Castration