PentaLyte decreases lung injury after aortic occlusion-reperfusion.

Abstract

Lung injury often occurs after hepatoenteric ischemia, with xanthine oxidase (XO, an oxidant-generating enzyme), released from reperfusing liver and intestines, mediating a significant component of this injury. Since pentastarch administration decreases intestinal reperfusion injury, we determined whether resuscitation with PentaLyte (a pentastarch-containing solution) would decrease hepatoenteric reperfusion injury, xanthine oxidase release, and concomitant lung injury after aortic occlusion- reperfusion. Aortic occlusion was established in rabbits for 40 min, and was followed by 3 h of reperfusion, during which either PentaLyte or lactated Ringer's solution-based resuscitation was administered. Sham-operated animals served as controls. Hepatoenteric reperfusion injury, as manifested by release of the enzyme aspartate aminotransferase and decreased gastric intramucosal pH, was significantly (p < 0.0167) attenuated by PentaLyte administration after aortic occlusion-reperfusion, as compared with its occurrence in animals given lactated Ringer's solution. The release of XO after aortic occlusion-reperfusion was 4-fold smaller after PentaLyte administration than after resuscitation with lactated Ringer's solution (p < 0.05). Pulmonary injury, as defined by an increase in bronchoalveolar lavage fluid (BALF) protein content and lactate dehydrogenase (LDH) activity, was 4-fold less after PentaLyte administration following aortic occlusion-reperfusion than after administration of lactated Ringer's solution (p < 0.05). We conclude that remote pulmonary injury is significantly decreased by concomitant PentaLyte-mediated reduction of hepatoenteric reperfusion injury and XO release.

• Authors: R N Axon, M S Baird, J D Lang, A E Brix, V G Nielsen
• Journal: American journal of respiratory and critical care medicine (Am J Respir Crit Care Med) Vol. 157 Issue 6 Pt 1 Pg. 1982-90 (Jun 1998) ISSN: 1073-449X [Print] United States
• PMID: 9620936 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Blood Proteins
• Electrolytes
• Hydroxyethyl Starch Derivatives
• Isotonic Solutions
• PentaLyte
• Plasma Substitutes
• Ringer's Lactate
• Phenylephrine
• Sodium Bicarbonate
• L-Lactate Dehydrogenase
• Xanthine Oxidase
• Aspartate Aminotransferases
• Glucose

Topics

• Animals
• Aorta, Thoracic (physiology)
• Aspartate Aminotransferases (blood)
• Blood Proteins (analysis)
• Bronchoalveolar Lavage Fluid (chemistry)
• Constriction
• Electrolytes (administration & dosage)
• Gastric Mucosa (metabolism)
• Glucose (administration & dosage)
• Hydrogen-Ion Concentration
• Hydroxyethyl Starch Derivatives (administration & dosage)
• Infusions, Intravenous
• Intestines (blood supply)
• Isotonic Solutions (administration & dosage)
• L-Lactate Dehydrogenase (blood)
• Liver (blood supply)
• Male
• Phenylephrine (administration & dosage)
• Plasma Substitutes (administration & dosage)
• Rabbits
• Reperfusion Injury (complications, metabolism, therapy)
• Respiratory Distress Syndrome (etiology, prevention & control)
• Resuscitation
• Ringer's Lactate
• Sodium Bicarbonate (administration & dosage)
• Xanthine Oxidase (blood)