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Hetastarch (Pentastarch)

A derivative of STARCH used as a plasma substitute in the treatment of hemorrhage.

Also Known As:

Pentastarch; Hydroxyethyl Starch; Braun Brand of Pentastarch; Bristol-Myers Squibb Brand of Pentastarch; Elohes; Fresenius Brand of Pentastarch; Fresenius Kabi Brand of Hydroxyethylstarch; HAES-steril; Hemohes; Hespan; Pentafraction; Pentaspan; Plasmasteril; Rhône-Poulenc Rorer Brand of Pentastarch; Starch, Hydroxyethyl; Starch, 2-hydroxyethyl ether

Networked: 926 relevant articles (68 outcomes, 160 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Haase, Nicolai: 11 articles (01/2015 - 01/2011)
2.	Perner, Anders: 11 articles (01/2015 - 01/2011)
3.	Alam, Hasan B: 9 articles (03/2015 - 01/2006)
4.	Reinhart, Konrad: 9 articles (01/2015 - 01/2008)
5.	Intaglietta, Marcos: 9 articles (11/2013 - 06/2003)
6.	Tsai, Amy G: 9 articles (11/2013 - 06/2003)
7.	Wetterslev, Jørn: 8 articles (01/2015 - 01/2011)
8.	Vincent, Jean-Louis: 7 articles (02/2013 - 08/2004)
9.	Jacob, Matthias: 7 articles (01/2013 - 05/2004)
10.	Rehm, Markus: 6 articles (01/2015 - 05/2004)

Related Diseases

1.	Hypotension (Low Blood Pressure) 06/01/2012 - "Hydroxyethyl starch (HES) preloading is more consistently effective in reducing the incidence and severity of hypotension. " 04/01/2011 - "As refractory hypotension and cardiovascular collapse, because leakage of fluids from intravascular to extravascular space are common cause of death in this toxicity, we propose that hydroxyethyl starch can dominate this refractory hypotension and consequently acute metabolic response." 09/01/1999 - "Significantly more patients in the Hartmann's group (n = 38, 47.5%) developed hypotension than in the pentastarch group (n = 10, 12.5%) (P < 0.0001). " 10/01/1995 - "Hypotension occurred in 45% of patients who received hetastarch vs 85% of those who received only LR (P < 0.05), and minimum systolic blood pressure was lower in the LR group than in the hetastarch group (85 +/- 12 vs 93 +/- 12 mm Hg [mean +/- SD]; P < 0.05). " 04/01/2009 - "Pre-loading with hetastarch decreases the incidence and severity of hypotension after spinal anesthesia for cesarean delivery. "
2.	Hemorrhagic Shock 01/01/2011 - "Hypertonic saline hydroxyethyl starch (HH) has been recommended for first line treatment of hemorrhagic shock. " 09/01/2006 - "To study the effect of hydroxyethyl starch (HES) on vascular reactivity of rat during hemorrhagic shock and its mechanism. " 01/01/2012 - "[Comparative effects of low and medium molecular hydroxyethyl starch (HES) solutions on hemorrhagic shock in rats]." 06/01/2011 - "Small volume 7.5% NaCl with 6% Dextran-70 or 6% and 10% hetastarch are associated with arrhythmias and death after 60 minutes of severe hemorrhagic shock in the rat in vivo." 05/01/2010 - "To observe the change in bone marrow after intraosseous hypertonic saline- hydroxyethyl starch (HSH) in dogs with hemorrhagic shock. "
3.	Shock 05/01/1999 - "In preclinical studies, its use in shock models was associated with an improvement in outcome compared with alternatives, such as albumin or 6% hetastarch in saline. " 06/01/2015 - "Hydroxyethyl starch was able to prevent hemodynamic shock but not intestinal lesions. " 01/01/2015 - "Animals in shock were then resuscitated with 6% hydroxyethyl starch. " 04/01/2010 - "Renal effects of saline-based 10% pentastarch versus 6% tetrastarch infusion in ovine endotoxemic shock." 12/01/2007 - "Hydroxyethyl starch (HES) solution is an effective colloidal infusion solution in humans for treatment of hypovolaemic shock, but it has not been compared with fluids currently available for use in horses. "
4.	Hemorrhage 03/01/2001 - "In CHT without hemorrhage, giving 20% albumin or 10% hetastarch improved NSS. " 01/01/2014 - "In this study, the effects of bleeding followed by replacement with hydroxyethyl starch 130/0.4 (HES) or lactated Ringer's (LR) on cerebral oxygenation and electroencephalogram-derived parameters were investigated. " 07/01/2004 - "Hydroxyethyl starch-induced postoperative bleeding in cardiac surgery patients: more trials needed?" 04/01/2000 - "Studies show conflicting effects of intraoperative hetastarch administration on postoperative bleeding. " 04/01/1996 - "An increase in prothrombin time was demonstrated in children who received greater than 20 mL/kg of 6% hetastarch (p = 0.006); however, no difference in clinical bleeding or blood product requirement was demonstrated between the hetastarch or albumin groups receiving more than 20 mL/kg. This study demonstrated that 6% hetastarch is safe and an effective plasma volume expander in the postoperative management of children, using volumes up to 20 mL/kg. Close laboratory monitoring and careful evaluation of clinical bleeding are suggested when larger doses of hetastarch are administered because of prolongation of the prothrombin time with more than 20 mL/kg of hetastarch."
5.	Burns 01/01/2010 - "Therefore, our study addressed the question whether hyperoncotic hydroxyethyl starch (HES) 200/0.5 (10%) administered in combination with crystalloids within the first 24 hours after injury is as effective as 'crystalloids only' in severe burn injury patients. " 02/01/1994 - "Pentafraction does not appreciably ameliorate the adverse microcirculatory consequences observed at the site of burn injury." 05/01/1989 - "We have measured albumin leakage from standardized scald burns in the rat jejunum with and without variously sized fractions of intravenous macromolecules of hydroxyethyl starch (HES) used as a sealing agent. " 01/01/2013 - "There are limited data on the efficacy of early fluid resuscitation with third-generation hydroxyethyl starch (HES 130) in burn injury. " 01/01/2013 - "Early fluid resuscitation with hydroxyethyl starch 130/0.4 (6%) in severe burn injury: a randomized, controlled, double-blind clinical trial."

Related Drugs and Biologics

1.	Colloids (Colloid)
2.	HES 130-0.4
3.	Oxygen
4.	Ringer's solution
5.	Ringer's lactate
6.	Hemoglobins (Hemoglobin)
7.	Polygeline
8.	Ephedrine
9.	Carbon Monoxide
10.	crystalloid solutions

Related Therapies and Procedures

1.	Resuscitation
2.	Spinal Anesthesia
3.	Hemodilution
4.	Cardiopulmonary Bypass (Heart-Lung Bypass)
5.	Cesarean Section (Caesarean Section)