[Animal experiment studies of chronic thiamine deficiency. Changes in carbohydrate and amino acid metabolism under resting and load conditions].

Abstract

The metabolic effects of thiamine deficiency on the metabolism of lactate, acid-base and amino acids were evaluated both with and without muscular exercise in a controlled animal experiment. Thiamine deficiency - in good correlation with its biologic halftime and also with reports in the literature - caused with a latency of 17-56 days and statistically proven in parallel the following effects: hyperlactemia; in comparison to controls elevated plasma concentrations of threonine, alanine, glutamic acid, glutamine, histidine, methionine, taurine, valine, isoleucine and leucine; distinctly lowered - also in comparison to controls - plasma concentrations of arginine and tryptophan. Furthermore, in the thiamine deficient rats predetermined muscular exercise caused the following effects, also occurring concomitantly: life threatening lactacidosis; marked - statistically prover - disturbance of the homeostasis of alanine, glycine, methionine and arginine; distinctly - and statistically significant - elevated plasma concentration of proline; statistically significantly lowered plasma concentrations of taurine. The reasons for all these changes under thiamine deficiency is most likely a metabolic one primarily due to a disturbance of the utilization of pyruvate in the liver. An additional disturbance of both the transsulfuration pathway and the Krebs-Henseleit-cycle seems probable. The physiologic regulation of pyruvate, lactate, alanine, serine and tyrosine during muscular exercise in correlation to the controls is being discussed.

• Authors: M Schwartau, M Doehn, P Jürgens
• Journal: Zeitschrift fur Ernahrungswissenschaft (Z Ernahrungswiss) Vol. 23 Issue 3 Pg. 206-18 (Sep 1984) ISSN: 0044-264X [Print] Germany
• Vernacular Title: Tierexperimentelle Studie zum chronischen Thiaminmangel. Veränderungen des Kohlenhydrat- und Aminosäurenstoffwechsels unter Ruhe- und Belastungsbedingungen.
• PMID: 6438931 (Publication Type: English Abstract, Journal Article)

Chemical References

• Amino Acids
• Bicarbonates
• Carbohydrates
• Lactates
• Carbon Dioxide
• Lactic Acid
• Oxygen

Topics

• Amino Acids (blood)
• Animals
• Bicarbonates (blood)
• Carbohydrates (blood)
• Carbon Dioxide (blood)
• Hydrogen-Ion Concentration
• Lactates (blood)
• Lactic Acid
• Male
• Oxygen (blood)
• Partial Pressure
• Physical Exertion
• Rats
• Rats, Inbred Strains
• Rest
• Swimming
• Thiamine Deficiency (blood)