Methionine (L-Methionine)

12/01/2003 - "The efficacy of rMETase is due to depletion of plasma methionine, an amino acid for which tumors generally have an abnormally high methionine requirement. "
01/01/2002 - "We conclude that enteral dietary methionine restriction is safe and tolerable in adults with metastatic solid tumors and results in significant reduction in plasma methionine levels."
02/12/2008 - "This laboratory and others have shown that agents that inhibit the in vitro catalytic activity of methionine aminopeptidase-2 (MetAP2) are effective in blocking angiogenesis and tumor growth in preclinical models. "
09/01/1991 - "These results confirm that methionine deprivation blocks cells from processing into the G1 phase and recycling, and that it is effective in inhibiting tumor growth in cultures and in vivo."
01/01/1986 - "To date few if any protective effects of methionine have been observed against tumor formation in extrahepatic tissues. "

01/01/1989 - "Methionine supplementation significantly improved body weight gain and feed efficiency in males but not in females. "
11/01/1987 - "The addition of .18% supplemental methionine significantly improved body weight and feed efficiency. "
01/01/2013 - "A higher dietary concentration of methionine (5.9 g/kg) improved growth performance of broilers with low HW in terms of body weight gain and feed conversion ratio. "
11/01/1984 - "Supplementing the 0 ppm lead diet with methionine improved body weight gain. "
01/01/2012 - "In study 1, a total of 40 pigs in five units, all cross-breds between Large White and Mong Cai, with an average initial body weight of 20.5 kg were randomly assigned to four treatments consisting of a basal diet containing 45% of dry matter (DM) from ensiled cassava leaves (ECL) and ensiled cassava root supplemented with 0%, 0.05%, 0.1% and 0.15% DL-methionine (as DM). "

01/01/2010 - "Feed intake, weight gain and feed conversion efficiency (FCE) were much higher in ration I than in ration II and these parameters significantly improved by addition of methionine in both rations. "
02/01/1997 - "Increasing DL-methionine supplementation significantly improved daily weight gain and feed conversion efficiency. "
01/01/1989 - "As supplement both with the fluid feed and with the concentrated feed this compound shows exclusively positive results even in already ruminant calves with regard to live weight gain, N retention and the content of free methionine in the blood serum of the test animals."
09/01/1986 - "Increasing the methionine content of the diets to the 100% level for SAA (1977) consistently improved weight gain of younger birds. "
01/01/2003 - "The present investigation was carried out to study the ameliorative effects of L-Met (L-methionine) on Pb-exposed mice by the measurement of the weight gain, the weight of organs, the Hb content, the level of lipid peroxidation (LPO), and the Pb and Fe contents of selected organs and serum. "

01/01/2006 - "The IEC method is more time-consuming but less expensive in reagent cost and allows simultaneous determination of plasma methionine concentration which may help to explain the underlying mechanism responsible for hyperhomocysteinemia."
01/01/2014 - "The aim of this study was to analyze the influence of hyperhomocysteinemia induction by methionine supplementation considering different levels and periods of exposure in mice. "
07/05/2012 - "The results of the present study demonstrate the relevance of ANXII in vivo and suggest that methionine-induced hyperhomocysteinemia may reverse hyperfibrinolysis in APL."
08/01/2010 - "Postoral methionine load hyperhomocysteinemia was found in 4.5% of subjects before therapy vs. 98.5% at the end of study period (P = 0.001). "
03/01/2006 - "We performed a placebo-controlled, blinded, crossover trial to examine whether AGE reduces macro- and microvascular endothelial dysfunction during acute hyperhomocysteinemia induced by an oral methionine challenge in healthy subjects. "

12/01/2014 - "In this study, C57BL/6J mice were fed a methionine-choline‑deficient (MCD) diet for eight weeks in order to induce hepatic steatohepatitis. "
07/01/2011 - "Rats fed the methionine-deficient diet with L-CBHcy developed fatty liver. "
01/01/2009 - "Metabolism of methionine in vivo: impact of pregnancy, protein restriction, and fatty liver disease."
03/01/2008 - "Methionine deficiency and hepatic injury in a dietary steatohepatitis model."
12/01/1964 - "METHIONINE DEFICIENCY AND FATTY LIVER IN MALE AND FEMALE RATS."