Pharmacotherapy of Painful Diabetic Neuropathy: A Clinical Update.

Abstract

The rising prevalence of diabetes mellitus (DM) leads on to an increase in chronic diabetic complications. Diabetic peripheral neuropathies (DPNs) are common chronic complications of diabetes. Distal symmetric polyneuropathy is the most prevalent form. Most patients with DPN will remain pain-free; however, painful DPN (PDPN) occurs in 6-34% of all DM patients and is associated with reduced health-related-quality-of-life and substantial economic burden. Symptomatic treatment of PDPN and diabetic autonomic neuropathy is the key treatment goals. Using certain patient related characteristics, subjects with PDPN can be stratified and assigned targeted therapies to produce better pain outcomes. The aim of this review is to discuss the various pathogenetic mechanisms of DPN with special reference to the mechanisms leading to PDPN and the various pharmacological and non-pharmacological therapies available for its management. Recommended pharmacological therapies include anticonvulsants, antidepressants, opioid analgesics, and topical medications.

• Authors: Cornelius Fernandez James, Shiva Tripathi, Kyriaki Karampatou, Divya V Gladston, Joseph M Pappachan
• Journal: Sisli Etfal Hastanesi tip bulteni (Sisli Etfal Hastan Tip Bul) Vol. 56 Issue 1 Pg. 1-20 ( 2022) ISSN: 1302-7123 [Print] Turkey
• PMID: 35515975 (Publication Type: Journal Article, Review)
• Copyright: ©Copyright 2022 by The Medical Bulletin of Sisli Etfal Hospital - Available online at www.sislietfaltip.org.