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NAD (NADH)

A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)

Also Known As:

NADH; DPN; Nicotinamide-Adenine Dinucleotide; Nadide; Dihydronicotinamide Adenine Dinucleotide; Adenine Dinucleotide, Dihydronicotinamide; Dinucleotide, Dihydronicotinamide Adenine; Dinucleotide, Nicotinamide-Adenine; Nicotinamide Adenine Dinucleotide; Nucleotide, Diphosphopyridine; Coenzyme I; Diphosphopyridine Nucleotide; Adenosine 5'-(trihydrogen diphosphate), P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt

Networked: 3789 relevant articles (129 outcomes, 437 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tesfaye, Solomon: 15 articles (01/2015 - 08/2005)
2.	Boothman, David A: 14 articles (01/2015 - 01/2005)
3.	Nencioni, Alessio: 13 articles (09/2015 - 01/2009)
4.	Dobrowsky, Rick T: 12 articles (09/2015 - 06/2003)
5.	Ying, Weihai: 12 articles (04/2015 - 01/2007)
6.	Mayevsky, Avraham: 12 articles (01/2014 - 05/2002)
7.	Ross, David: 12 articles (03/2011 - 03/2002)
8.	Bruzzone, Santina: 11 articles (09/2015 - 10/2006)
9.	Vinik, Aaron I: 11 articles (02/2015 - 12/2004)
10.	Savchenko, A A: 11 articles (01/2014 - 09/2002)

Related Diseases

1.	Peripheral Nervous System Diseases (PNS Diseases) 01/01/2015 - "Tang-tong-fang (TTF) is a Chinese herbal formula that has been shown to be beneficial in diabetic peripheral neuropathy (DPN), a common complication secondary to diabetic microvascular injury. " 10/01/2011 - "Painful diabetic peripheral neuropathy (DPN) is common, is associated with significant reduction in quality of life and poses major treatment challenges to the practising physician. " 09/01/2009 - "The purpose of this systematic review is to evaluate current evidence in the literature on the efficacy of Semmes Weinstein monofilament examination (SWME) in diagnosing diabetic peripheral neuropathy (DPN). " 11/01/2015 - "The aim of this study is to explore the relationship between serum phosphorylated neurofilament-heavy chain (pNF-H) and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes.Serum" 09/01/2015 - "However, no previous studies have investigated its association with diabetic peripheral neuropathy (DPN). "
2.	Pain (Aches) 02/01/2012 - "Throughout a 13-week trial, DMQ was effective, with an acceptable safety profile, for treatment of DPN pain. " 01/01/2014 - "Desvenlafaxine was effective in relieving pain associated with DPN at doses of 200 and 400 mg/day, and improved activity impairment at all doses assessed. " 10/01/2013 - "WBV appears to be an effective, non-invasive treatment for pain associated with DPN. " 10/01/2013 - "The purpose of this study was to determine the efficacy of whole body vibration therapy (WBV) as a treatment for pain associated with DPN. " 04/01/2015 - "More studies are required to better evaluate the efficacy and safety of this topical compound for relieving pain in DPN."
3.	Neoplasms (Cancer) 07/07/2015 - "This improved understanding of NAD(+) metabolism revived interest in NAD(+)-boosting strategies to manage a wide spectrum of diseases, ranging from diabetes to cancer. " 02/01/2014 - "In this study we addressed the potential of NAD(+) depletion as an anti-cancer strategy and assessed the combination with radiation. " 12/01/2011 - "In summary, our study has provided the first evidence that NAD(+) treatment induces autophagy in cancer cells such as Neuro2a cells, which contributes to the NAD(+)-induced decrease in cancer cell survival." 12/16/2010 - "As tumor cells are generally hypoxic with increased NADH levels, the dynamic control of Brca1 by a 'metabolic switch' found in this study not only provides an important link between tumor metabolism and tumor suppressor expression but also suggests a potential chemo preventative or therapeutic strategy for HNSCC by blocking NADH-dependent CtBP1 activity at early stages of HNSCC carcinogenesis." 05/01/2010 - "Published clinical trials on NAD depleting drugs for cancer treatment were summarised for safety and efficacy. "
4.	Anoxia (Hypoxia) 04/01/2008 - "However, the use of Ca(2+) free-media in slices from >22 month old rats improved recovery and delayed NADH hyperoxidation (2.5 min hypoxia after hsd). " 07/15/2003 - "This interaction, and consequent repression of p53-dependent transcription, is relieved under hypoxia or hypoxia-mimicking conditions that are known to increase levels of intracellular NADH. " 01/01/2002 - "IHT caused reorganization of mitochondrial energy metabolism favoring NAD-dependent oxidation and improving the protection against acute hypoxia. " 04/01/2014 - "The objective of this study was to investigate the role of exogenous NAD(+) supplementation in hypoxia/reoxygenation (HR)-stressed H9c2 cardiac myoblasts. " 07/01/1999 - "Reduced nicotinamide adenine dinucleotide videofluorescence studies have shown the heterogeneous nature of hypoxia. "
5.	Wounds and Injuries (Trauma) 01/01/2016 - "Fittingly, in rat wounds treated with the ER‑β agonist (DPN), epidermal regeneration was accelerated. " 01/01/2014 - "AR-inhibition in vivo markedly attenuated the I/R-induced liver injuries, maintained the homeostasis of NAD(P)(H) contents and redox status, and suppressed the caspase-dependent apoptosis pathway. " 01/01/2014 - "One of the most notable protective functions of NAD is to delay axonal degenerations caused by various neurodegenerative injuries. " 05/01/2013 - "DPN-P participants also reported greater risk of hospitalizations for fall-related injuries, and greater fear of falling. " 03/01/2013 - "Therapeutic intervention with antithrombin 6 hrs after trauma restored nutritive perfusion and tissue oxygenation (functional capillary density: 469±22cm/cm; nicotinamide adenine dinucleotide autofluorescence: 61±5 aU [p < 0.05]) and reduced inflammatory leukocyte adherence (237±20 cells/mm; [p < 0.05]) toward values found in nontraumatized controls (functional capillary density: 573±13cm/cm; nicotinamide adenine dinucleotide autofluorescence: 56±2 aU; leukocyte adherence: 204±20 cells/mm;). "

Related Drugs and Biologics

1.	NAD (NADH)
2.	pregabalin (Lyrica)
3.	Adenosine Triphosphate (ATP)
4.	benzoquinone (quinone)
5.	Enzymes
6.	Biological Markers (Surrogate Marker)
7.	3- (3- dimethylamino- 1- ethyl- 2- methylpropyl)phenol
8.	Niacinamide (Nicotinamide)
9.	nicotinamide-beta-riboside
10.	Pyruvic Acid (Pyruvate)

Related Therapies and Procedures

1.	Decompression
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Amputation
4.	Induced Heart Arrest (Cardioplegia)
5.	Dye Lasers