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Diabetic Neuropathies (Diabetic Neuropathy)

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Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)

Also Known As:

Diabetic Neuropathy; Neuropathy, Diabetic; Diabetic Amyotrophy; Diabetic Polyneuropathy; Asymmetric Diabetic Proximal Motor Neuropathy; Diabetic Asymmetric Polyneuropathy; Diabetic Mononeuropathy; Diabetic Mononeuropathy Simplex; Diabetic Neuropathy, Painful; Mononeuropathy, Diabetic; Symmetric Diabetic Proximal Motor Neuropathy; Amyotrophies, Diabetic; Amyotrophy, Diabetic; Asymmetric Polyneuropathies, Diabetic; Asymmetric Polyneuropathy, Diabetic; Autonomic Neuropathies, Diabetic; Autonomic Neuropathy, Diabetic; Diabetic Amyotrophies; Diabetic Asymmetric Polyneuropathies; Diabetic Autonomic Neuropathies; Diabetic Mononeuropathies; Diabetic Mononeuropathy Simplices; Diabetic Neuralgias; Diabetic Neuropathies, Painful; Diabetic Polyneuropathies; Mononeuropathies, Diabetic; Mononeuropathy Simplex, Diabetic; Mononeuropathy Simplices, Diabetic; Neuralgias, Diabetic; Neuropathies, Diabetic; Neuropathies, Diabetic Autonomic; Neuropathies, Painful Diabetic; Neuropathy, Diabetic Autonomic; Neuropathy, Painful Diabetic; Painful Diabetic Neuropathies; Painful Diabetic Neuropathy; Polyneuropathies, Diabetic; Polyneuropathies, Diabetic Asymmetric; Polyneuropathy, Diabetic; Polyneuropathy, Diabetic Asymmetric; Simplex, Diabetic Mononeuropathy; Simplices, Diabetic Mononeuropathy; Diabetic Autonomic Neuropathy; Diabetic Neuralgia; Neuralgia, Diabetic

Networked: 2646 relevant articles (304 outcomes, 523 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Neuralgia (Stump Neuralgia)
3.	Postherpetic Neuralgia
4.	Fibromyalgia (Fibrositis)
5.	Diabetic Neuropathies (Diabetic Neuropathy)

Experts

1.	Feldman, Eva L: 25 articles (12/2015 - 10/2002)
2.	Sima, Anders A F: 21 articles (07/2009 - 03/2002)
3.	Kamiya, Hideki: 20 articles (12/2015 - 09/2002)
4.	Ziegler, Dan: 20 articles (10/2015 - 03/2003)
5.	Sharma, Shyam S: 20 articles (10/2015 - 01/2005)
6.	Obrosova, Irina G: 18 articles (11/2014 - 01/2002)
7.	Nakamura, Jiro: 15 articles (12/2015 - 09/2002)
8.	Naruse, Keiko: 14 articles (03/2015 - 09/2002)
9.	Moore, R Andrew: 14 articles (01/2015 - 01/2008)
10.	Yorek, Mark A: 13 articles (10/2015 - 12/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Diabetic Neuropathies:

1.	Aldehyde Reductase (Aldose Reductase)IBA 09/01/1997 - "Despite numerous attempts over 16 years, the results of aldose reductase inhibitor (ARI) trials for the treatment of diabetic neuropathy have not proven efficacy. " 05/01/2006 - "Aldose reductase pathway inhibition improved vascular and C-fiber functions, allowing for pressure-induced vasodilation restoration during severe diabetic neuropathy." 06/01/2001 - "Aldose reductase inhibition ameliorates pupillary light reflex and F-wave latency in patients with mild diabetic neuropathy." 09/01/1998 - "[Effects of the aldose reductase inhibitor on diabetic polyneuropathy--the efficacy of F wave measurement]." 01/01/1994 - "The clinical efficacy of an aldose reductase (AR) inhibitor in diabetic polyneuropathy depends on its bioavailability at the site(s) of AR in peripheral nerves. "
2.	gabapentin (Neurontin)FDA LinkGeneric 09/01/2010 - "This study suggests that the T/A combination treatment is as effective as gabapentin in the treatment of painful diabetic neuropathy in patients with Type 2 diabetes." 03/05/1999 - "Gabapentin displays efficacy against abnormal sensory processing in diabetic rats and may be of benefit for treating painful diabetic neuropathy." 05/01/2005 - "Based on the reviewed randomised controlled trials, gabapentin shows good efficacy, a favourable side-effect profile with lack of drug interactions and therefore it may be a first choice treatment in painful diabetic neuropathy, especially in the elderly. " 01/01/2001 - "Studies have also shown gabapentin to be effective and well tolerated in the treatment of diabetic neuropathy. " 02/01/1999 - "Gabapentin in the treatment of painful diabetic neuropathy: a placebo controlled, double blind, crossover trial."
3.	Thioctic Acid (Lipoic Acid)IBA 06/01/2008 - "Alpha-lipoic acid (LA), a potent antioxidant, has been shown to be an effective treatment for diabetic neuropathy when given intravenously. " 01/01/2007 - "Thioctic acid (-lipoic acid) is another substance known to enhance energy metabolism in mitochondria and to be beneficial in diabetic neuropathy. " 07/01/2005 - "Moreover, given the potential role of oxidative stress in the pathogenesis of secondary complications in diabetes, alpha-lipoic acid might be beneficial in the prevention/treatment of these complications as was recently shown for diabetic neuropathy." 12/01/2000 - "Lipoic acid supplementation has been found to be beneficial in preventing neurovascular abnormalities in diabetic neuropathy. " 01/01/1999 - "Here we review the current evidence from the clinical trials that assessed the therapeutic efficacy and safety of thioctic acid in diabetic polyneuropathy. "
4.	pregabalin (Lyrica)FDA Link 01/01/2014 - "Results of this study suggest that treatment with pregabalin gives faster and better improvement in diabetic neuropathy." 01/01/2014 - "The results also imply that the relief from diabetic neuropathy (as per DNE score) is superior with pregabalin administration. " 04/01/2005 - "This was a 6-week, randomized, double-blind, multicenter study evaluating the efficacy of pregabalin in the treatment of painful diabetic neuropathy. " 10/01/2015 - "Pregabalin, an approved treatment for painful diabetic neuropathy, was included as a positive control. " 07/01/2015 - "Dosing time-dependent changes in the analgesic effect of pregabalin on diabetic neuropathy in mice."
5.	Insulin (Novolin)FDA Link 09/01/2015 - "Ex-4 and other GLP-1R agonists may compensate for the reduced insulin effects on neurons, thereby being beneficial for the treatment of diabetic neuropathy." 12/01/2006 - "[Intensified insulin therapy plus antineuritic medication is more effective than antineuritics alone in painful diabetic neuropathy]." 10/01/1987 - "In order to study the effects of improved metabolic control on painful diabetic polyneuropathy, 15 patients were treated with continuous subcutaneous insulin infusion over a 12 month period. " 05/01/2014 - "Intranasal insulin ameliorates experimental diabetic neuropathy. " 04/01/2009 - "Intranasal insulin ameliorates experimental diabetic neuropathy."
6.	Capsaicin (Zostrix)FDA Link 11/01/1991 - "Study results suggest that topical capsaicin cream is safe and effective in treating painful diabetic neuropathy." 06/01/1991 - "The results of this study indicate that topical capsaicin 0.075% cream is safe and effective in managing painful diabetic neuropathy." 07/01/2013 - "0.025% capsaicin gel for the treatment of painful diabetic neuropathy: a randomized, double-blind, crossover, placebo-controlled trial." 01/01/1992 - "We conducted an 8-wk controlled study with topical 0.075% capsaicin in subjects with chronic severe painful diabetic neuropathy who were unresponsive or intolerant to conventional therapy. " 01/01/1992 - "We examined the effects of topical 0.075% capsaicin cream on thermal and vibration thresholds in 22 subjects with painful diabetic neuropathy who participated in a double-blind vehicle-controlled therapeutic trial. "
7.	sorbinilIBA 04/01/1988 - "There was no significantly beneficial effect of sorbinil on clinical or neurophysiological measurements of nerve function in patients with established diabetic neuropathy. " 04/01/1986 - "In a study of 11 patients with severely painful diabetic neuropathy treated with sorbinil for 3 weeks [placebo-controlled in single-blind fashion (n = 8)], pains (as assessed on a 0 to 20 rating scale) improved from a mean score of 16 down to 8, with deterioration following drug withdrawal. " 11/15/1985 - "After an improvement in motor and sensory nerve conduction velocities was demonstrated in asymptomatic diabetic patients taking sorbinil (compared with velocities during a placebo period), 11 patients with painful diabetic neuropathy were treated with sorbinil for three weeks without alterations in diabetic management or control. " 06/01/1985 - "It is concluded that sorbinil treatment results in some improvement in peripheral nerve function in symptomatic diabetic polyneuropathy, but that the long-term effect may be of limited value." 09/01/1988 - "In a double-blind placebo-controlled trial the effect of Sorbinil (250 mg daily) on diabetic neuropathy was examined. "
8.	Streptozocin (Streptozotocin)FDA Link 07/15/1990 - "Both drugs were effective for the treatment of diabetic neuropathy characterized by decreased motor nerve conduction velocity, that is, slowing of tail and sciatic-tibial motor nerve conduction velocities in streptozocin-induced diabetic rats was prevented during 3 weeks by intubating Di-Cl-PSH or beta-NSH at 50 mg/kg/day. " 08/01/1995 - "We used the model of streptozotocin-induced diabetic neuropathy (SDN) and evaluated the efficacy of LA supplementation in improving nerve blood flow (NBF), electrophysiology, and indexes of oxidative stress in peripheral nerves affected by SDN, at 1 month after onset of diabetes and in age-matched control rats. " 09/01/2014 - "In the present study, we investigated the neuroprotective effect of ethanolic extract of Cleome viscosa (EECV) against streptozotocin (STZ) induced diabetic neuropathy in Wistar rats. " 06/15/2014 - "In this study, we determined the interaction of NMDARs and GABAB receptors in streptozotocin (STZ)-induced diabetic neuropathy. " 09/27/2013 - "In this study we evaluated the effect of Urtica dioica (UD) extract against memory dysfunction and hypoalgesia on a mouse model of streptozotocin (STZ) induced diabetic neuropathy. "
9.	Nerve Growth Factor (NGF)IBA 11/01/1994 - "These findings indicate that, while NGFR expression is normal in the STZ-diabetic neuropathy model, the marked decrease in receptor saturation observed in diabetics may reflect low peripheral NGF levels, which in consequence leads to the apparent deprivation of neuronal NGF in diabetic rats." 07/01/2002 - "These results suggest that gene transfer with an NGF-producing herpes-based vector may prove useful in the treatment of diabetic neuropathy." 11/01/1996 - "One study of NGF in patients with diabetic neuropathy found that the drug improved neurologic function and produced an increase in the patients' ability to sense cooling or painful heat. " 01/01/2011 - "However, the results of a phase 3 trial were moderate and, therefore, not enough to encourage widespread use of NGF in the treatment of diabetic neuropathy. " 02/01/2003 - "However, a phase 3 trial in diabetic neuropathy and a phase 2 trial in HIV-related neuropathy have failed to demonstrate any substantial effect of treatment with NGF. "
10.	ONO 2235 (epalrestat)IBA 10/01/2008 - "Although data are limited, it is strongly suggested that epalrestat is a highly effective and safe agent for the treatment of diabetic neuropathy." 05/01/1996 - "Although data are limited, they strongly suggest that epalrestat is a highly effective and safe agent for the treatment of diabetic neuropathy." 11/01/1993 - "Epalrestat 150 mg/day for 12 weeks improved motor and sensory nerve conduction velocity, and vibration threshold compared with baseline and placebo in patients with diabetic neuropathy. " 10/01/2008 - "In this study, more than 2000 patients with diabetic neuropathy, who were treated with epalrestat for 3-12 months, were analyzed to assess the efficacy and the adverse reactions of the drug. " 05/01/1996 - "More than 5000 patients with diabetic neuropathy who were treated with epalrestat for 3-12 months were treated to analyze the efficacy and the adverse reactions of the drug in this study. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2013 - "Most randomized, double-blind, placebo-controlled trials (RCTs) published in painful neuropathy have been conducted in patients with diabetes and to what extent a treatment which is found effective in painful diabetic polyneuropathy can be expected to relieve other conditions like chemotherapy- or HIV-induced neuropathy is unknown. " 10/01/2015 - "This approach could be beneficial for conditions with prominent peripheral pathophysiologic mechanisms (e.g., painful diabetic neuropathy, chemotherapy-induced neuropathy). " 03/21/1980 - "Fifty-nine patients referred for painful diabetic neuropathy of the lower extremities were evaluated for depression and response to antidepressant drug therapy in a double-blind controlled study. " 04/01/2015 - "This article discusses the typical clinical findings, electrophysiology findings, and MRN appearances of common hereditary or acquired neuropathies such as chronic inflammatory demyelinating neuropathy, multifocal motor neuropathy, diabetic neuropathy, chemotherapy-induced neuropathy, and postsurgical neuropathy. " 01/01/2015 - "From guideline to patient: a review of recent recommendations for pharmacotherapy of painful diabetic neuropathy."
2.	Transcutaneous Electric Nerve Stimulation (TENS) 01/12/2010 - "TENS is probably effective in treating painful diabetic neuropathy (2 Class II studies). " 06/01/2011 - "Microcurrent transcutaneous electric nerve stimulation in painful diabetic neuropathy: a randomized placebo-controlled study." 09/01/2010 - "The aim of the study was to determine whether TENS improves small fibre function diminished because of painful diabetic neuropathy. " 09/01/2010 - "Effect of transcutaneous electrical nerve stimulation on sensation thresholds in patients with painful diabetic neuropathy: an observational study." 06/01/2004 - "In conclusion, our study indicates that the new TENS device "Salutaris" is a convenient, non-pharmacological option for primary or adjuvant treatment of painful diabetic neuropathy."
3.	Decompression 02/01/2008 - "We concluded that peripheral nerve decompression can be used effectively in the treatment of diabetic neuropathy patients." 01/01/2014 - "Efficacy of decompression of multiple lower-extremity peripheral nerves in patients with painful diabetic neuropathy was confirmed in this study. " 06/01/2015 - "Decompression of nerves of the lower extremity in patients with painful diabetic polyneuropathy has no beneficial effect on nerve conduction study variables 12 months after surgery." 06/01/2015 - "To investigate the influence of nerve decompression at potential entrapment sites in the lower extremity in painful diabetic polyneuropathy on nerve conduction study variables. " 06/01/2015 - "Nerve conduction studies after decompression in painful diabetic polyneuropathy."
4.	Transplantation (Transplant Recipients) 06/01/2005 - "These findings suggest that transplantation of EPCs from cord blood may be a useful treatment for diabetic neuropathy." 01/01/2015 - "Angioblast-like cells were obtained from mouse embryonic stem cells and transplantation of these cells improved several physiological impairments in diabetic polyneuropathy: hypoalgesia, delayed nerve conduction velocities, and reduced blood flow in sciatic nerve and plantar skin. " 01/01/2015 - "The aim of this study is to evaluate the therapeutic potential of DPSC transplantation for diabetic polyneuropathy. " 03/01/2015 - "Here, we investigated the effects of BM-MNCs transplantation in diabetic polyneuropathy using BM-MNCs derived from adult (16-week-old) diabetic (AD), adult non-diabetic (AN) or young (8-week-old) non-diabetic (YN) rats. " 01/01/2015 - "Transplantation of cultured dental pulp stem cells into the skeletal muscles ameliorated diabetic polyneuropathy: therapeutic plausibility of freshly isolated and cryopreserved dental pulp stem cells."
5.	Intramuscular Injections 01/01/1984 - "Double blind placebo controlled trials of dialy intramuscular injections of 40 mg of mixed gangliosides were carried out in ALS and diabetic neuropathy. " 11/01/1987 - "The efficacy of daily intramuscular injection of mixed gangliosides (Cronassial) for highly symptomatic diabetic neuropathy was investigated in a randomized double-blind trial. " 05/01/2015 - "To evaluate the safety and efficacy of a plasmid (VM202) containing two human hepatocyte growth factor isoforms given by intramuscular injections in patients with painful diabetic neuropathy. "