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Peripheral Nervous System Diseases (PNS Diseases)

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Diseases of the peripheral nerves external to the brain and spinal cord, which includes diseases of the nerve roots, ganglia, plexi, autonomic nerves, sensory nerves, and motor nerves.

Also Known As:

PNS Diseases; Peripheral Neuropathy; Neuropathy, Peripheral; Peripheral Neuropathies; PNS (Peripheral Nervous System) Diseases; Peripheral Nervous System Disease; Peripheral Nervous System Disorders; Nerve Disease, Peripheral; Nerve Diseases, Peripheral; PNS Disease; Peripheral Nerve Disease; Peripheral Nerve Diseases

Networked: 5557 relevant articles (315 outcomes, 660 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Neoplasms (Cancer)
3.	Neuralgia (Stump Neuralgia)
4.	Postherpetic Neuralgia
5.	Multiple Myeloma

Experts

1.	Cavaletti, Guido: 43 articles (09/2015 - 11/2003)
2.	Loprinzi, Charles L: 24 articles (02/2016 - 07/2002)
3.	Argyriou, Andreas A: 21 articles (12/2014 - 08/2005)
4.	Kalofonos, Haralabos P: 19 articles (12/2014 - 08/2005)
5.	Tesfaye, Solomon: 17 articles (01/2015 - 08/2005)
6.	Dougherty, Patrick M: 15 articles (10/2015 - 01/2004)
7.	Egashira, Nobuaki: 15 articles (09/2015 - 01/2009)
8.	Kawashiri, Takehiro: 15 articles (09/2015 - 01/2009)
9.	Obrosova, Irina G: 15 articles (07/2015 - 01/2002)
10.	Bennett, Gary J: 15 articles (06/2014 - 05/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Peripheral Nervous System Diseases:

1.	NAD (NADH)IBA 01/01/2015 - "Tang-tong-fang (TTF) is a Chinese herbal formula that has been shown to be beneficial in diabetic peripheral neuropathy (DPN), a common complication secondary to diabetic microvascular injury. " 10/01/2011 - "Painful diabetic peripheral neuropathy (DPN) is common, is associated with significant reduction in quality of life and poses major treatment challenges to the practising physician. " 09/01/2009 - "The purpose of this systematic review is to evaluate current evidence in the literature on the efficacy of Semmes Weinstein monofilament examination (SWME) in diagnosing diabetic peripheral neuropathy (DPN). " 11/01/2015 - "The aim of this study is to explore the relationship between serum phosphorylated neurofilament-heavy chain (pNF-H) and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes.Serum" 09/01/2015 - "However, no previous studies have investigated its association with diabetic peripheral neuropathy (DPN). "
2.	pregabalin (Lyrica)FDA Link 09/01/2013 - "In conclusion, pregabalin was efficacious in reducing the severity of L-OHP- and PTX-induced peripheral neuropathy. " 09/01/2012 - "Therefore, there is a possibility that the PTX -induced peripheral neuropathy may be improved by pregabalin administration. " 04/01/2011 - "In conclusion, 4-week pregabalin treatment improved HRV in patients with painful diabetic peripheral neuropathy. " 05/01/2014 - "This is the first reported placebo-controlled trial of pregabalin in patients with inadequately treated painful diabetic peripheral neuropathy. " 05/01/2014 - "Pregabalin in patients with inadequately treated painful diabetic peripheral neuropathy: a randomized withdrawal trial."
3.	bortezomib (Velcade)FDA Link 11/15/2011 - "Bortezomib (Velcade) is a potent and reversible PI that has been used successfully in the treatment of patients with MM. While the use of bortezomib has helped to change the natural history of MM, it is not universally effective and is associated with reversible peripheral neuropathy that can limit short-term and long-term use. " 09/01/2014 - "To examine the safety, feasibility and efficacy of acupuncture in reducing bortezomib-induced peripheral neuropathy (BIPN) symptoms. " 05/01/2014 - "Subcutaneous administration of bortezomib offers similar efficacy to standard intravenous administration in the treatment of multiple myelom, with an improved safety for lower rate of peripheral neuropathy." 02/01/2012 - "The incorporation of bortezomib as a consolidation therapy improved the clinical outcome with the expense of rather frequent development of peripheral neuropathy." 09/01/2015 - "The relative risks of bortezomib-induced peripheral neuropathy compared to placebo were increased for all-grade (RR = 4.89; 95 % CI, 2.52-9.51) and high-grade (RR = 4.53; 95 % CI, 2.04-10.07) peripheral neuropathy (for randomized controlled trials only). "
4.	Paclitaxel (Taxol)FDA LinkGeneric 01/01/2008 - "Peripheral neuropathy (PN) is one of the most common and dose-limiting side effects of paclitaxel, a chemiotherapeutic drug of proven efficacy in various tumours. " 11/01/2008 - "The present studies were conducted to evaluate the efficacy of cannabinoid CB(2) receptor activation in suppressing painful peripheral neuropathy evoked by chemotherapeutic treatment with the antitumor agent paclitaxel. " 03/15/2010 - "Although all participants developed peripheral neuropathy, improvement in neuropathic symptoms began with the decrease or cessation of paclitaxel. " 05/01/2015 - "The aim of the current study was to elucidate the involvement of transcriptional factors nuclear factor-κB (NF-κB) and its causal interaction with CX3CL1 signaling in the paclitaxel-induced painful peripheral neuropathy. " 01/01/2015 - "RWDD3 and TECTA variants not linked to paclitaxel induced peripheral neuropathy in North American trial Alliance N08C1."
5.	oxaliplatin (Eloxatin)FDA LinkGeneric 11/01/2012 - "Such an approach would be beneficial in a clinical trial setting to monitor the efficacy of interventions and in prospective studies of survivorship to determine the true burden of peripheral neuropathy in oxaliplatin-treated patients." 06/01/2015 - "It is suggested that PC has a therapeutic potential against oxaliplatin-induced peripheral neuropathy due to its antioxidant property and modulation of microglial activities." 11/21/2011 - "The antineoplastic efficacy of oxaliplatin, a widely used anticancer drug, is restricted by its adverse effects such as peripheral neuropathy. " 01/01/2014 - "The present study was designed to evaluate the efficacy of NC-4016 and its association with peripheral neuropathy, which is a primary dose-limiting factor in oxaliplatin therapy. " 08/01/2011 - "The aim of this study was to clarify the efficacy of GJG for peripheral neuropathy associated with oxaliplatin therapy. "
6.	gabapentin (Neurontin)FDA LinkGeneric 08/01/2003 - "The aim of the present study was to investigate the effect of gabapentin in a recently developed mouse model of peripheral neuropathy. " 09/01/2012 - "A gastroretentive gabapentin formulation for the treatment of painful diabetic peripheral neuropathy: efficacy and tolerability in a double-blind, randomized, controlled clinical trial." 09/01/2010 - "As part of his home medication regimen, the patient was taking gabapentin for peripheral neuropathy. " 07/01/2010 - "Therapeutic doses of gabapentin not only alleviate neuropathic symptoms but also improve cardiac autonomic function in diabetic patients with peripheral neuropathy." 07/01/2010 - "Gabapentin therapy improves heart rate variability in diabetic patients with peripheral neuropathy."
7.	duloxetine (Cymbalta)FDA Link 01/01/2012 - "Economic evaluation of duloxetine as a first-line treatment for painful diabetic peripheral neuropathy in Mexico." 01/01/2010 - "Medline was searched from January 2005 to September 2009 using the key words duloxetine and peripheral neuropathy for clinical trials limited to human research published in English and duloxetine and pharmacology in the nervous system. " 05/01/2015 - "She was administered duloxetine on day 90 after the end of the previous therapy because of the peripheral neuropathy. " 10/01/2015 - "Effect of duloxetine in Japanese patients with chemotherapy-induced peripheral neuropathy: a pilot randomized trial." 09/01/2013 - "Review of a study of duloxetine for painful chemotherapy-induced peripheral neuropathy."
8.	Thalidomide (Thalomid)FDA Link 08/01/2008 - "We report a patient with scleromyxoedema and peripheral neuropathy treated successfully with thalidomide. " 01/01/2007 - "Because thalidomide may cause peripheral neuropathy, it is current practice to perform nerve conduction studies to exclude subclinical neuropathy before treatment. " 02/01/2005 - "Children treated with thalidomide should undergo regular neurophysiologic studies in order to detect presymptomatic or progressive peripheral neuropathy." 11/01/2000 - "In contrast to humans, Beagle dogs did not develop thalidomide-induced peripheral neuropathy under conditions of the study." 09/01/1999 - "Our experience with low-dose, long-term thalidomide therapy suggests that peripheral neuropathy is not as common as suggested by other studies (up to 50% of patients treated with thalidomide in some series)."
9.	Amitriptyline (Elavil)FDA LinkGeneric 08/01/1998 - "Patients (n = 26) with peripheral neuropathy were treated with amitriptyline. " 03/01/1997 - "Peripheral neuropathy in scleroderma successfully treated with amitriptyline." 02/01/1988 - "Amitriptyline-related peripheral neuropathy. " 10/01/1985 - "Peripheral neuropathy following amitriptyline overdose." 08/01/1998 - "To evaluate the efficacy of combining electrotherapy with amitriptyline for the management of chronic painful peripheral neuropathy in patients with type 2 diabetes. "
10.	mecobalamin (methylcobalamin)IBA 01/01/2014 - "Safety and efficacy of intravenous ultra-high dose methylcobalamin treatment for peripheral neuropathy: a phase I/II open label clinical trial." 06/01/2008 - "However, more precise, double-blind and randomised control studies are necessary to confirm the efficacy of mecobalamin on hyperhomocysteinaemia, peripheral neuropathy interaction, and cardiovascular, neurological and osteoporotic mortality or morbidity." 04/01/2015 - "Response to: 'Methylcobalamine is effective in peripheral neuropathies'." 04/01/2015 - "Methylcobalamine is effective in peripheral neuropathies." 09/01/2013 - "Although methylcobalamin has some positive effects on peripheral nervous system disorders, the mechanism through which it affects neurons are not entirely known. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2007 - "ALC has demonstrated efficacy and high tolerability in the treatment of neuropathies of various aetiologies, including chemotherapy-induced peripheral neuropathy (CIPN). " 11/01/2012 - "Chemotherapy-induced peripheral neuropathy: a new treatment option." 01/01/2013 - "Efficacy of contact needle therapy for chemotherapy-induced peripheral neuropathy." 05/01/2010 - "The outcome will be improved symptom awareness by oncology clinicians and patients, leading to fewer chemotherapy-induced peripheral neuropathy-related devastating effects on functionality and quality of life." 02/01/1984 - "Peripheral neuropathy in osteosclerotic myeloma: clinical and electrodiagnostic improvement with chemotherapy."
2.	Injections 01/01/2014 - "Platelet-rich plasma guided injections: clinical application in peripheral neuropathies." 01/01/1976 - "injections of acrylamide (15 mg/kg) daily for 10 days to induce a peripheral neuropathy. " 09/15/2015 - "injections of either physiological saline (control), 0.6 mg/kg, 2mg/kg or 6 mg/kg OX and assessed for peripheral neuropathy and cognitive function up to 11 months after treatment completion. " 01/01/1991 - "15% of the patients treated with Eta plus radiotherapy have received less than 15 Eta injections, mainly because of skin rashes (5%), peripheral neuropathies (3%) or patient refusal (3%). " 07/01/2014 - "Image-guided anesthetic nerve injections are a viable and safe therapeutic option in sensory peripheral neuropathies that provides significant pain relief when conservative therapy fails and surgery is not desired or contemplated. "
3.	Immunotherapy 01/01/2012 - "Her peripheral neuropathy improved after immunotherapy. " 01/01/2012 - "We included randomised or quasi-randomised controlled trials involving participants of any age treated with any type of immunotherapy for anti-myelin-associated glycoprotein antibody-associated demyelinating peripheral neuropathy with monoclonal gammopathy of undetermined significance and of any severity.Our" 01/01/2006 - "We included randomised or quasi-randomised controlled trials of participants of any age treated with any type of immunotherapy for anti-myelin-associated glycoprotein antibody associated demyelinating peripheral neuropathy with monoclonal gammopathy of undetermined significance of any severity. " 06/01/2014 - "Maintenance chemotherapy or immunotherapy has not been proven to impact on overall survival and only one clinical trial that explored the administration of monthly paclitaxel for 1 year showed a benefit in terms of progression-free survival (PFS), but at the cost of maintained alopecia and increased peripheral neuropathy. " 01/01/2006 - "To examine the efficacy of any form of immunotherapy in reducing disability and impairment resulting from IgM anti-myelin associated glycoprotein paraprotein-associated demyelinating peripheral neuropathy. "
4.	Electric Stimulation Therapy (Electrotherapy) 11/01/1997 - "To evaluate the efficacy of transcutaneous electrotherapy for chronic painful peripheral neuropathy in patients with type 2 diabetes. " 04/01/2010 - "To review different types of electrotherapy for the treatment of painful diabetic peripheral neuropathy. " 04/01/2010 - "Electrotherapy for the treatment of painful diabetic peripheral neuropathy: a review." 04/01/2010 - "The efficacy of different types of electrotherapy for painful diabetic peripheral neuropathy has been evaluated in 15 studies; the effects of transcutaneous electrical nerve stimulation are consistent. " 08/01/1998 - "Our clinical observations suggest that transcutaneous electrotherapy is effective in reducing the pain associated with peripheral neuropathy. "
5.	Renal Dialysis (Hemodialysis) 01/01/2013 - "The aim of the study was to assess the influence of high-tone external muscle stimulation (HTEMS) therapy on clinical and electrophysiologycal parameters in hemodialysis patients with uremic peripheral neuropathy. " 01/01/1991 - "This study was undertaken to compare the effect of 1 year hemodialysis (HD) or hemodiafiltration (HDF) treatment on peripheral neuropathy. " 10/01/1981 - "In order to detect early or subclinical evidence of peripheral neuropathy, several newer electrophysiologic techniques, including latencies of late responses (H reflex and F response) and sural nerve sensory studies, were evaluated in addition to routine motor and sensory conduction in 17 randomly selected children (mean age 14.2 years) undergoing hemodialysis (12 of whom had no clinical evidence of peripheral neuropathy) and 20 age-matched normal control subjects. " 06/01/2012 - "The prevalence of peripheral neuropathy in hemodialysis patients." 09/01/2010 - "We evaluated the relationship between autonomic dysfunction and peripheral neuropathy in chronic hemodialysis patients in a cross-sectional study. "