Abstract | ETHNOPHARMACOLOGICAL RELEVANCE:
Swertiamarin (SW), which belongs to iridoid glycosides, is one of the main components of Swertia plants in Gentianaceae family, including Swertia pseudochinensis H. Hara and Swertia mileensis T. N. Ho et W. L. Shi. There are mainly used in traditional Chinese medicine for the treatment of hepatic and biliary disease such as jaundice. AIM OF THIS STUDY: MATERIALS AND METHODS: Healthy rats were randomly divided into the control, model (ANIT, 50 mg/kg), ursodeoxycholic acid (UDCA, 80 mg/kg), and low-dose (SW, 80 mg/kg), medium-dose (SW, 100 mg/kg), and high-dose (SW, 150 mg/kg) groups. The hepatic protective effect of SW was preliminarily evaluated by measurement of serum biochemical indicators and liver morphological evaluation. Moreover, metabolomics and proteomics analysis were used to explore the protective mechanism of SW on cholestasis. The expression of related proteins was determined by Western blot and polymerase chain reaction, and the important proteins were verified by cell experiments in vitro. RESULTS: CONCLUSIONS: SW can alleviate ANIT-induced cholestasis, which by activating the farnesoid X receptor and bile acid excretion pathway.
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Authors | Mengge Shi, Jie Tang, Tong Zhang, Han Han |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 291
Pg. 115164
(Jun 12 2022)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 35278607
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 Elsevier B.V. All rights reserved. |
Chemical References |
- Bile Acids and Salts
- Iridoid Glucosides
- Iridoid Glycosides
- Iridoids
- Pyrones
- swertiamarin
- 1-Naphthylisothiocyanate
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Topics |
- 1-Naphthylisothiocyanate
(toxicity)
- Animals
- Bile Acids and Salts
- Cholestasis
(chemically induced, drug therapy, prevention & control)
- Iridoid Glucosides
- Iridoid Glycosides
(pharmacology, therapeutic use)
- Iridoids
(pharmacology)
- Liver
- Pyrones
- Rats
- Swertia
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