Sphingolipids

A class of membrane lipids that have a polar head and two nonpolar tails. They are composed of one molecule of the long-chain amino alcohol sphingosine (4-sphingenine) or one of its derivatives, one molecule of a long-chain acid, a polar head alcohol and sometimes phosphoric acid in diester linkage at the polar head group. (Lehninger et al, Principles of Biochemistry, 2nd ed)

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Networked: 594 relevant articles (8 outcomes, 50 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hannun, Yusuf A: 17 articles (10/2015 - 08/2004)
2.	Ogretmen, Besim: 10 articles (10/2015 - 08/2004)
3.	Merrill, Alfred H: 9 articles (08/2015 - 05/2004)
4.	Levade, Thierry: 9 articles (01/2015 - 12/2002)
5.	Hornemann, Thorsten: 8 articles (07/2015 - 09/2009)
6.	Kurek, Krzysztof: 8 articles (04/2015 - 01/2012)
7.	Bielawski, Jacek: 8 articles (01/2015 - 09/2006)
8.	Obeid, Lina M: 7 articles (10/2015 - 02/2008)
9.	Futerman, Anthony H: 7 articles (08/2015 - 08/2002)
10.	Gulbins, Erich: 7 articles (06/2015 - 12/2006)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2014 - "In this study, we summarise novel experimental evidences linking sphingolipids to oestrogen-activated effects, highlight the role of sphingolipids in cancer cells and discuss new avenues for future research at the intersection between oestrogen and sphingolipid signalling. " 01/30/2013 - "However, the complete profile of sphingolipids in wheat bran and their contributions to the cancer preventive effect of wheat bran have not been fully explored until this study. " 01/01/2011 - "These studies not only expand our knowledge of sphingolipids, but can also suggest novel targets for cancer treatments." 11/01/2010 - "Thus, stereoisomers of 2'-OHCers can be potentially utilized as novel molecular tools to study lipid-protein interactions, cell signaling phenomena and to understand the role of hydroxylated sphingolipids in cancer biology, pathogenesis and therapy." 03/01/2009 - "In the present study, the mechanisms of tumor suppression by dietary sphingolipids were investigated. "
2.	Insulin Resistance 08/04/2015 - "Sphingolipids have garnered attention for their role in insulin resistance and lipotoxic cell death. " 05/01/2015 - "There is increasing evidence that sphingolipids play a role in insulin resistance and type 2 diabetes (T2DM). " 01/01/2015 - "Sphingolipids play an important role in the development of insulin resistance. " 01/01/2014 - "Sphingolipids are increasingly recognized to play a role in insulin resistance and diabetes. " 09/01/2013 - "Elevated levels of these sphingolipids in tissues and in the circulation have been associated with insulin resistance and diabetes. "
3.	Atherosclerosis 05/01/2015 - "Sphingosine-1-phosphate(S1P), one of the biologically active sphingolipids, increases TNF-α production in NKT cells and induces the migration of NKT cells, suggesting that S1P can regulate inflammatory processes in atherogenesis. " 01/01/2013 - "Sphingolipids and atherosclerosis." 07/01/2006 - "The review also highlights involvement of sphingolipids in cell proliferation, apoptosis, and in processes implicated to atherosclerosis." 07/01/2006 - "Sphingolipids and cell signaling: involvement in apoptosis and atherogenesis." 07/15/2005 - "The effect of dietary sphingolipids on plasma sphingomyelin metabolism and atherosclerosis."
4.	Cystic Fibrosis (Mucoviscidosis) 01/01/2013 - "The results of initial clinical studies suggest that interfering with sphingolipids may be a novel treatment strategy for cystic fibrosis." 01/01/2013 - "Recent studies have shown that sphingolipids, especially ceramide, play a crucial role in the pathogenesis of cystic fibrosis. " 03/01/2009 - "Studies that evaluate the diagnostic and clinical relevance of sphingolipids in patients with cystic fibrosis are needed." 01/01/2010 - "The role of sphingolipids and ceramide in pulmonary inflammation in cystic fibrosis." 01/01/2010 - "Here we discuss recent findings related to the role of sphingolipids, in particular ceramide, in cystic fibrosis and the bacterial infections associated with that disease. "
5.	Neuroblastoma 08/01/2002 - "Here, we present an overview of the current understanding of the multiple levels at which sphingolipids function in drug resistance, with an emphasis on sphingolipid function in neuroblastoma and how modulation of sphingolipid metabolism may be used as a novel treatment paradigm." 05/01/2012 - "We applied a metabolic approach to investigate the role of sphingolipids in cell density-induced growth arrest in neuroblastoma cells. " 08/01/2002 - "Sphingolipids in neuroblastoma: their role in drug resistance mechanisms." 08/01/2001 - "Here, we report that lysosphingolipids with naturally occurring stereochemical configurations induce apoptosis in mouse neuroblastoma Neuro2a cells. " 06/15/1990 - "Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines."

Related Drugs and Biologics

1.	Sphingosine
2.	Enzymes
3.	sphingosine 1-phosphate (sphingosine-1-phosphate)
4.	fingolimod (FTY720)
5.	Lipids
6.	Glycerophospholipids
7.	Cholesterol Esters (Cholesteryl Esters)
8.	Cholesterol
9.	Ceramides
10.	Gangliosides

Related Therapies and Procedures

1.	Chemoprevention
2.	Heterologous Transplantation (Xenotransplantation)
3.	Lasers (Laser)
4.	Therapeutics
5.	Drug Therapy (Chemotherapy)