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Ursodeoxycholic Acid (Urso)

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An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.

Also Known As:

Urso; Ursodiol; 3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid; Antigen Brand of Ursodeoxycholic Acid; Aventis Brand of Ursodeoxycholic Acid; Axcan Brand of Ursodeoxycholic Acid; CP Brand of Ursodeoxycholic Acid; Cholit-Ursan; Cholofalk; Delursan; Destolit; Estedi Brand of Ursodeoxycholic Acid; Falk Brand of Ursodeoxycholic Acid; Farmasa Brand of Ursodeoxycholic Acid; Galen Brand of Ursodeoxycholic Acid; Heumann Brand of Ursodeoxycholic Acid; Niddapharm Brand of Ursodeoxycholic Acid; Norgine Brand of Ursodeoxycholic Acid; Orphan Brand of Ursodeoxycholic Acid; Provalis Brand of Ursodeoxycholic Acid; Sanofi Synthelabo Brand of Ursodeoxycholic Acid; Sodium Ursodeoxycholate; Tramedico Brand of Ursodeoxycholic Acid; Urdox; Ursacholic Acid; Urso Heumann; Ursobilane; Ursochol; Ursofalk; Ursogal; Ursolite; Ursolvan; Vita Brand of Ursodeoxycholic Acid; Zambon Brand of Ursodeoxycholic Acid; 3 alpha,7 beta Dihydroxy 5 beta cholan 24 oic Acid; Acid, Deoxyursocholic; Acid, Ursacholic; Acid, Ursodeoxycholic; Ursodeoxycholate, Sodium; Deoxyursocholic Acid; Cholan-24-oic acid, 3,7-dihydroxy-, (3alpha,5beta,7beta)-

Networked: 1805 relevant articles (301 outcomes, 304 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Bile Acids and Salts: 3397
    - Cholic Acids: 8
      - Deoxycholic Acid: 627
        Ursodeoxycholic Acid: 1805
        2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester: 9
        Bamet-UD2: 8
        diamminebis(ursodeoxycholate(O,O'))platinum(II): 7
        glycoursodeoxycholic acid: 5
        24-norursodeoxycholic acid: 4
        sarcoursodeoxycholic acid: 4
        HS 1030: 3
        HS 1183: 3
        N''-ursodeoxycholyldiethylene-N,N,N'-triacetic acid: 2
        ursodeoxycholic acid-3-O-glucuronide: 2
        23-methylursodeoxycholic acid: 1
        3,7-dihydroxy-7-methylcholanoic acid: 1
        6-fluoro-ursodeoxycholic acid: 1
        isoursodeoxycholic acid: 1
        PABA-ursodeoxycholic acid: 1
        ursodeoxycholyl N-carboxymethylglycine: 1
        Ursometh: 1
        3,6-dihydroxy-6-methylcholanoic acid
        3,7-dihydroxy-20,22-methylenecholan-23-oic acid
        3,7-dihydroxy-22,23-methylenecholan-24-oic acid
        3,7-dihydroxy-7-ethylcholanoic acid
        3,7-dihydroxy-7-n-propylcholanoic acid
        5-(7-hydroxy-3-O-phosphonocholyl)aminosalicylic acid
        6-ethyl-23-methyl-3,7-dihydroxycholan-24-oic acid
        6-methylursodeoxycholic acid
        cholane-3,7,24-triol-24-sulfate
        homoursodeoxycholic acid
        sarcosylsarcoursodeoxycholic acid
        taurine-ursodeoxycholate conjugate
        ursodeoxycholate-3-sulfate
        ursodeoxycholic acid 3,7-disulfate
        ursodeoxycholic acid 7-oleyl ester
        ursodeoxycholic acid N-acetylglucosaminide
        ursodeoxycholylcysteic acid
  - Cholanes
    - Cholic Acids: 8
      - Deoxycholic Acid: 627
        Ursodeoxycholic Acid: 1805
        2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester: 9
        Bamet-UD2: 8
        diamminebis(ursodeoxycholate(O,O'))platinum(II): 7
        glycoursodeoxycholic acid: 5
        24-norursodeoxycholic acid: 4
        sarcoursodeoxycholic acid: 4
        HS 1030: 3
        HS 1183: 3
        N''-ursodeoxycholyldiethylene-N,N,N'-triacetic acid: 2
        ursodeoxycholic acid-3-O-glucuronide: 2
        23-methylursodeoxycholic acid: 1
        3,7-dihydroxy-7-methylcholanoic acid: 1
        6-fluoro-ursodeoxycholic acid: 1
        isoursodeoxycholic acid: 1
        PABA-ursodeoxycholic acid: 1
        ursodeoxycholyl N-carboxymethylglycine: 1
        Ursometh: 1
        3,6-dihydroxy-6-methylcholanoic acid
        3,7-dihydroxy-20,22-methylenecholan-23-oic acid
        3,7-dihydroxy-22,23-methylenecholan-24-oic acid
        3,7-dihydroxy-7-ethylcholanoic acid
        3,7-dihydroxy-7-n-propylcholanoic acid
        5-(7-hydroxy-3-O-phosphonocholyl)aminosalicylic acid
        6-ethyl-23-methyl-3,7-dihydroxycholan-24-oic acid
        6-methylursodeoxycholic acid
        cholane-3,7,24-triol-24-sulfate
        homoursodeoxycholic acid
        sarcosylsarcoursodeoxycholic acid
        taurine-ursodeoxycholate conjugate
        ursodeoxycholate-3-sulfate
        ursodeoxycholic acid 3,7-disulfate
        ursodeoxycholic acid 7-oleyl ester
        ursodeoxycholic acid N-acetylglucosaminide
        ursodeoxycholylcysteic acid

Experts

1.	Lindor, Keith D: 28 articles (12/2015 - 02/2002)
2.	Poupon, Raoul: 19 articles (12/2015 - 03/2002)
3.	Trauner, Michael: 18 articles (06/2015 - 05/2002)
4.	Marschall, Hanns-Ulrich: 15 articles (02/2016 - 05/2005)
5.	Beuers, Ulrich: 14 articles (01/2014 - 09/2002)
6.	Corpechot, Christophe: 9 articles (12/2015 - 03/2002)
7.	Parés, Albert: 9 articles (12/2015 - 07/2003)
8.	Angulo, Paul: 9 articles (02/2010 - 02/2002)
9.	Talwalkar, Jayant A: 8 articles (10/2013 - 05/2002)
10.	Fickert, Peter: 8 articles (01/2012 - 04/2005)

Related Diseases

1.	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 11/01/2000 - "Ursodeoxycholic acid (UDCA) is a safe and effective medical therapy for most patients with primary biliary cirrhosis (PBC), but some patients show an incomplete response. " 02/01/2000 - "Ursodeoxycholic acid (UDCA) is a safe and effective medical therapy for most patients with primary biliary cirrhosis (PBC). " 11/01/1998 - "A 1-year randomized, double-blind, placebo-controlled trial was carried out in 50 patients with primary biliary cirrhosis, who had already been treated with ursodeoxycholic acid for at least 1 year, but had not achieved complete disease remission. " 05/01/2005 - "This case report indicates a serological remission and a marked histological improvement in a female patient with an early stage of primary biliary cirrhosis (stage I) during therapy under ursodeoxycholic acid. " 02/01/2005 - "Despite evidence for therapeutic efficacy with ursodeoxycholic acid (UDCA) in primary biliary cirrhosis (PBC), only 30-50% of patients achieve complete biochemical remission within 1 year of therapy. "
2.	Liver Diseases (Liver Disease) 02/01/1994 - "Ursodeoxycholic acid has been reported to be beneficial for patients with various chronic cholestatic liver diseases. " 01/01/1994 - "Ursodeoxycholic acid (UDCA) is clinically beneficial in chronic cholestatic liver disease, but the underlying mechanisms are unclear. " 07/01/2012 - "Ursodeoxycholic acid (UDCA) is widely used for the treatment of liver dysfunction. " 02/01/2004 - "Ursodeoxycholic acid (UDCA) is widely used for the treatment of cholestatic liver diseases. " 02/01/2004 - "Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease."
3.	Cholestasis 01/01/2006 - "We have investigated whether maternal obstructive cholestasis during pregnancy (OCP) causes oxidative stress and apoptosis in rat placenta and whether treatment with ursodeoxycholic acid (UDCA, i.g., 60 microg/100 g b.wt./day, following complete biliary obstruction on day 14 of pregnancy) has protective effects on this organ. " 03/01/2003 - "Cholestasis and liver function tests improved significantly during treatment with ursodeoxycholic acid (750 mg per day). " 12/01/1997 - "[Successful therapy of persistent androgen-induced cholestasis with ursodeoxycholic acid]." 03/01/2000 - "These cases suggest that ursodeoxycholic acid may be an effective treatment for drug-associated cholestasis." 10/01/1995 - "In an uncontrolled series of three patients with cholestasis of pregnancy, ursodeoxycholic acid seemed to provide safe and effective therapy."
4.	Gallstones (Gallstone) 01/01/1989 - "Although most studies report that long-term bile acid treatment does not have protective effects, preliminary results suggest that low-dose ursodeoxycholic acid decreases the rate of gallstone recurrence in a subgroup of younger patients. " 06/01/1992 - "Pretreatment with ursodiol significantly improved while gallstone calcification interfered with fragmentation. " 06/01/2003 - "Of the cases in whom dissolution was achieved, all patients had multiple gallstones except for one with a solitary stone in Group I. Gallstones were not dissolved of any subject of group III. The results showed that ursodeoxycholic acid cholic therapy is more effective in the dissolution of multiple gallstones than of solitary ones. " 11/01/1997 - "Two multicenter, placebo-controlled, randomized, double-blind trials have demonstrated that the prophylactic use of ursodiol in males and females 18 to 70 years of age is effective for the prevention of gallstone formation in this patient population. " 11/01/2003 - "To determine if a 6-month regimen of prophylactic ursodeoxycholic acid is effective in the prevention of gallstones. "
5.	Pruritus (Itching) 12/01/1992 - "Ursodeoxycholic acid has been beneficial in pruritus and in liver function tests; an improvement in fetal prognosis should be evaluated in future controlled studies." 03/01/1997 - "Ursodeoxycholic acid (UDCA) administration provides a significant improvement in maternal pruritus and in the biochemical abnormalities, with no adverse effects in the mother or child. " 03/01/1992 - "During the initial 12 months urso treatment liver function tests improved significantly in all patients, pruritus improved in 60% of patients. " 01/01/2013 - " with placebo, ursodeoxycholic acid (UDCA) showed improvement in pruritus in five (228 women) out of seven trials. " 04/01/2014 - "The child was started on ursodeoxycholic acid following which the itching improved. "

Related Drugs and Biologics

1.	Cholesterol
2.	Chenodeoxycholic Acid (Chenix)
3.	Bile Acids and Salts (Bile Acids)
4.	Bilirubin
5.	Ursodeoxycholic Acid (Urso)
6.	Colchicine
7.	Primary sclerosing cholangitis
8.	Bezafibrate
9.	Interferon-alpha (Interferon Alfa)
10.	Prednisolone (Predate)

Related Therapies and Procedures

1.	Liver Transplantation
2.	Lithotripsy (Extracorporeal Shockwave Lithotripsy)
3.	Parenteral Nutrition
4.	Aftercare (After-Treatment)
5.	Oral Administration