Abstract | Introduction: Objective: Our research was designed to study the protective effect of LTC against cerebral ischemia-reperfusion (I/R) injury and reveal the underlying mechanism both in vivo and in vitro. Methods: PC12 cells treated with glucose deprivation/reperfusion (OGD/R) were used to simulate in vitro ischemia/reperfusion (I/R) injury. The cell viability, apoptosis rate, and protein expressions of PC12 cells were evaluated. In vivo validation of the protective effect of LTC was carried out by middle cerebral artery occlusion (MCAO)/reperfusion treatment, and the underlying mechanism of its anti-apoptosis ability was further revealed by immunohistochemistry staining and Western blotting. Results: Conclusion:
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Authors | Bo Pan, Jing Sun, Ziyu Liu, Lingxiao Wang, Huixia Huo, Yunfang Zhao, Pengfei Tu, Wei Xiao, Jiao Zheng, Jun Li |
Journal | Journal of advanced research
(J Adv Res)
Vol. 33
Pg. 215-225
(11 2021)
ISSN: 2090-1224 [Electronic] Egypt |
PMID | 34603791
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Chemical References |
- Drugs, Chinese Herbal
- longxuetongluo
- Mitogen-Activated Protein Kinases
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Topics |
- Animals
- Brain Ischemia
(drug therapy, prevention & control)
- Drugs, Chinese Herbal
- Endoplasmic Reticulum Stress
- Mitogen-Activated Protein Kinases
- Rats
- Reperfusion Injury
(drug therapy, prevention & control)
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