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Dietary Supplementation of Octacosanol Improves Exercise-Induced Fatigue and Its Molecular Mechanism.

Abstract
Several publications report that octacosanol (OCT) has different biological functions. This study was designed to evaluate the antifatigue effect and molecular mechanism of octacosanol (200 mg/(kg day)) in forced exercise-induced fatigue models of trained male C57BL/6 mice. Results showed that octacosanol ameliorated the mice's autonomic activities, forelimb grip strength, and swimming endurance, and the levels of liver glycogen (LG), muscle glycogen (MG), blood lactic acid (BLA), lactate dehydrogenase (LDH), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were also regulated. Gene analysis results showed that treatment with OCT upregulated 29 genes, while 38 genes were downregulated in gastrocnemius tissue. Gene ontology (GO) analyses indicated that these genes enriched functions in relation to myofibril, contractile fiber, and calcium-dependent adenosinetriphosphatase (ATPase) activity. Octacosanol supplementation significantly adjusted the messenger RNA (mRNA) and protein expression levels related to fatigue performance. Octacosanol has an observably mitigating effect in exercise-induced fatigue models, and its molecular mechanism may be related to the regulation of tripartite motif-containing 63 (Trim63), periaxin (Prx), calcium voltage-gated channel subunit α1 H (Cacna1h), and myosin-binding protein C (Mybpc3) expression.
AuthorsYaping Zhou, Fuliang Cao, Qiang Wu, Yi Luo, Tianyi Guo, Shuai Han, Mengzhen Huang, Zuomin Hu, Jie Bai, Feijun Luo, Qinlu Lin
JournalJournal of agricultural and food chemistry (J Agric Food Chem) Vol. 69 Issue 27 Pg. 7603-7618 (Jul 14 2021) ISSN: 1520-5118 [Electronic] United States
PMID34223764 (Publication Type: Journal Article)
Chemical References
  • Fatty Alcohols
  • 1-octacosanol
Topics
  • Animals
  • Dietary Supplements
  • Fatigue (drug therapy, genetics)
  • Fatty Alcohols
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Muscle, Skeletal
  • Physical Endurance
  • Swimming

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