Abstract | BACKGROUND: METHODS: The participants in this study comprised 153 patients with ITP and 70 healthy controls. We extracted data on sex, age, platelet counts, bleeding symptoms, and therapeutic responses, including those to prednisolone (PSL) and eltrombopag. Genomic DNA was isolated from peripheral blood and polymorphisms in TNF-α, IL-10, TGF-β1, and IFN-γ genes were analyzed using the PCR-SSP method. RESULTS: Our results showed that the TGF-β1 +869 C/C genotype might be related to ITP in Japanese patients. The IL-10 -592 C/C and A/A, -819 C/C and T/T, and -1082, -819, -592 ATA/ATA genotypes might be associated with reactivity to PSL. Furthermore, the IL-10 -592 C/A -819 C/T genotypes, IL-10 ACC/ATA genotype, and TGF-β1 +869 T/T and T/C genotypes might be linked to the response to eltrombopag. CONCLUSION: Our results indicate that analysis of polymorphisms in cytokine-encoding genes could aid in understanding PSL and eltrombopag responsiveness in Japanese patients with ITP.
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Authors | Shosaku Nomura, Misao Abe, Manabu Yamaoka, Tomoki Ito |
Journal | Journal of blood medicine
(J Blood Med)
Vol. 12
Pg. 421-429
( 2021)
ISSN: 1179-2736 [Print] New Zealand |
PMID | 34113203
(Publication Type: Journal Article)
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Copyright | © 2021 Nomura et al. |