Abstract | OBJECTIVE: To explore the effect of moxa-cone moxibustion at "Feishu" (BL13) and " Zhongfu" (LU1) on the contents of related inflammatory factors in serum and bronchoalveolar lavage fluid (BALF), and the expression of phosphatidy-linositol-3-kinase (PI3K), retinoic acid related orphan receptor γt (RORγt) and fork/wing helix transcription factor 3 (Foxp3) in lung tissue in asthma mice. METHODS: RESULTS: Compared with the normal group, the levels of IgE and IL-4 in serum and BALF, the expressions of PI3K and RORγt mRNA and protein in lung tissue were significantly increased (P<0.01), while the levels of IFN-γ, and the expressions of Foxp3 mRNA and protein were significantly reduced (P<0.01) in the model group. Compared with the model group, the levels of IgE and IL-4 in serum and BALF, the expressions of PI3K and RORγt mRNA and protein in lung tissue were significantly decreased (P<0.01, P<0.05), and the levels of IFN-γ in serum and BALF, the expressions of Foxp3 mRNA and protein in lung tissue were significantly increased (P<0.01) in the LY, EA and moxibustion groups. CONCLUSION: Moxa cone moxibustion at Shu- and Mu- acupoints of the lung meridian can reduce airway inflammatory reaction and control asthma attacks in asthma mice, which is closely related to its effects in regulating the expressions of RORγt and Foxp3 through PI3K signaling pathway.
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Authors | Yun Qiao, Hui-Ting Lei, Wei Yi, Cai-Jiao Zhao, Xing Xia, Bei Zhou, Jing-Lin Rui, Zeng-Duo Wang |
Journal | Zhen ci yan jiu = Acupuncture research
(Zhen Ci Yan Jiu)
Vol. 46
Issue 4
Pg. 272-7
(Apr 25 2021)
ISSN: 1000-0607 [Print] China |
PMID | 33931990
(Publication Type: Journal Article)
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Chemical References |
- Forkhead Transcription Factors
- Foxp3 protein, mouse
- Nuclear Receptor Subfamily 1, Group F, Member 3
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Topics |
- Acupuncture Points
- Animals
- Asthma
(genetics, therapy)
- Forkhead Transcription Factors
(genetics)
- Male
- Mice
- Moxibustion
- Nuclear Receptor Subfamily 1, Group F, Member 3
(genetics)
- Phosphatidylinositol 3-Kinases
(genetics)
- Signal Transduction
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