Anticancer Effects and Mechanisms of Action of Plumbagin: Review of Research Advances.

Abstract

Plumbagin (PLB), a natural naphthoquinone constituent isolated from the roots of the medicinal plant Plumbago zeylanica L., exhibited anticancer activity against a variety of cancer cell lines including breast cancer, hepatoma, leukemia, melanoma, prostate cancer, brain tumor, tongue squamous cell carcinoma, esophageal cancer, oral squamous cell carcinoma, lung cancer, kidney adenocarcinoma, cholangiocarcinoma, gastric cancer, lymphocyte carcinoma, osteosarcoma, and canine cancer. PLB played anticancer activity via many molecular mechanisms, such as targeting apoptosis, autophagy pathway, cell cycle arrest, antiangiogenesis pathway, anti-invasion, and antimetastasis pathway. Among these signaling pathways, the key regulatory genes regulated by PLB were NF-kβ, STAT3, and AKT. PLB also acted as a potent inducer of reactive oxygen species (ROS), suppressor of cellular glutathione, and novel proteasome inhibitor, causing DNA double-strand break by oxidative DNA base damage. This review comprehensively summarizes the anticancer activity and mechanism of PLB.

• Authors: Zhenhua Yin, Juanjuan Zhang, Lin Chen, Qingfeng Guo, Baocheng Yang, Wei Zhang, Wenyi Kang
• Journal: BioMed research international (Biomed Res Int) Vol. 2020 Pg. 6940953 ( 2020) ISSN: 2314-6141 [Electronic] United States
• PMID: 33344645 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2020 Zhenhua Yin et al.

Chemical References

• Antineoplastic Agents
• Liposomes
• Naphthoquinones
• Oxidants
• Plant Extracts
• Proteasome Inhibitors
• Reactive Oxygen Species
• Superoxides
• Glutathione
• Oxygen
• plumbagin

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Cell Line, Tumor
• DNA Breaks, Double-Stranded
• DNA Damage
• Drug Screening Assays, Antitumor
• Glutathione (metabolism)
• Humans
• Inhibitory Concentration 50
• Liposomes (chemistry)
• Mice
• Mice, Inbred C57BL
• Naphthoquinones (pharmacology)
• Neoplasm Metastasis
• Neoplasms (drug therapy)
• Oxidants (chemistry)
• Oxygen (chemistry)
• Plant Extracts (pharmacology)
• Plants, Medicinal (metabolism)
• Proteasome Inhibitors (pharmacology)
• Reactive Oxygen Species
• Superoxides (pharmacology)