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Squamous Cell Carcinoma (Epidermoid Carcinoma)

Subscribe to New Research on Squamous Cell Carcinoma

A carcinoma derived from stratified squamous epithelium. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)

Also Known As:

Epidermoid Carcinoma; Carcinoma, Squamous; Carcinoma, Squamous Cell; Carcinomas, Epidermoid; Carcinomas, Planocellular; Carcinomas, Squamous; Carcinomas, Squamous Cell; Epidermoid Carcinomas; Planocellular Carcinoma; Planocellular Carcinomas; Squamous Carcinoma; Squamous Carcinomas; Squamous Cell Carcinomas; Carcinoma, Epidermoid; Carcinoma, Planocellular

Networked: 27935 relevant articles (839 outcomes, 4471 trials/studies)

Relationship Network

Disease Context: Research Results

Neoplasms: 649836
- Neoplasms by Histologic Type: 1
  - Glandular and Epithelial Neoplasms: 332
    - Carcinoma: 115405
      - Squamous Cell Carcinoma: 27935
        Bowen's Disease: 607
        Urachal cancer: 106
        Sacral plexopathy: 10
    - Squamous Cell Neoplasms: 1188
      - Squamous Cell Carcinoma: 27935
        Bowen's Disease: 607
        Urachal cancer: 106
        Sacral plexopathy: 10

Related Diseases

1.	Neoplasms (Cancer)
2.	Adenocarcinoma
3.	Neoplasm Metastasis (Metastasis)
4.	Carcinoma (Carcinomatosis)
5.	Basal Cell Carcinoma (Rodent Ulcer)

Experts

1.	Sakagami, Hiroshi: 59 articles (10/2015 - 11/2002)
2.	Grandis, Jennifer R: 54 articles (09/2015 - 10/2003)
3.	Myers, Jeffrey N: 50 articles (12/2015 - 08/2002)
4.	Guo, Wei: 45 articles (01/2016 - 11/2002)
5.	Mendenhall, William M: 42 articles (10/2015 - 02/2002)
6.	Matsubara, Hisahiro: 41 articles (01/2016 - 02/2002)
7.	Baumann, Michael: 39 articles (10/2015 - 02/2002)
8.	Van Waes, Carter: 39 articles (09/2015 - 06/2002)
9.	Li, Yan: 39 articles (07/2015 - 05/2003)
10.	Grénman, Reidar: 38 articles (12/2015 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Squamous Cell Carcinoma:

1.	Cisplatin (Platino)FDA LinkGeneric 02/01/2004 - "cis-Diaminodichloroplatinum (II) (cisplatin) is one of the most effective anticancer drugs and is widely used for the treatment of squamous cell carcinoma (SCC). " 10/01/2010 - "p53 mutation, but not in vitro predictor genes of therapeutic efficacy of cisplatin, is clinically relevant in comparing partial and complete responder cases of maxillary squamous cell carcinoma." 09/01/2010 - "Cisplatin treatment is beneficial for approximately 20% of patients with head and neck squamous cell carcinoma (HNSCC). " 12/15/1986 - "Cisplatin was used successfully to treat 2 dogs with metastatic squamous cell carcinoma. " 05/01/1986 - "A pilot study was initiated to test the safety and efficacy of the simultaneous administration of high-dose cisplatin and irradiation in patients with locally advanced squamous cell carcinoma of the lung. "
2.	Fluorouracil (Carac)FDA LinkGeneric 11/01/2001 - "A prospective study was done to test the efficacy of 5-fluorouracil (topical and systemic) in multiple and unresectable histologically proven facial squamous cell carcinomas (SCC) secondary to XP. " 08/01/2012 - "Phase III trials in the 1990s for squamous cell carcinoma of the anus (SCCA) demonstrated 5-fluorouracil (5FU) and mitomycinC (MMC) chemoradiation (CRT) improved outcome compared to radiation (RT) alone, but local recurrence remained significant. " 05/01/2005 - "Recurrent squamous cell carcinoma in the neopharynx treated successfully with topical 5-fluorouracil." 03/01/2000 - "Topical 1% 5-FU is effective in the treatment of recurrent, incompletely excised, and selected untreated conjunctival squamous cell carcinomas. " 11/01/2009 - "Concurrent CRT with CDGP and 5-FU was effective and safe for locally advanced squamous cell carcinoma of the esophagus."
3.	cetuximab (Erbitux)FDA Link 08/01/2015 - "The efficacy of cetuximab-based BRT in locally advanced head and neck squamous cell carcinomas has been established. " 10/01/2014 - "Efficacy of cetuximab in the treatment of squamous cell carcinoma." 01/01/2014 - "Cetuximab (Cx) + radiation therapy (RT) is well-tolerated and has improved survival in patients (pts) with locoregionally advanced head and neck squamous cell carcinomas (LA-HNSCC). " 12/01/2011 - "Efficacy of cetuximab for unresectable or advanced cutaneous squamous cell carcinoma--a report of eight cases." 11/01/2010 - "Previous experiments have shown that application of the anti-EGFR monoclonal antibody C225 (cetuximab) improves local tumour control after irradiation in FaDu human squamous cell carcinoma (hSCC) due to the combined effect of decreased repopulation and improved reoxygenation. "
4.	Paclitaxel (Taxol)FDA LinkGeneric 06/01/2010 - "Paclitaxel is effective in relapsed head and neck squamous cell carcinoma: a retrospective study of 66 patients at a single institution." 07/01/2008 - "Improved local control by surgery and paclitaxel-based chemoradiation for esophageal squamous cell carcinoma: results of a retrospective non-randomized study." 04/01/2013 - "Taxol: efficacy against oral squamous cell carcinoma." 05/01/2012 - "Our in vitro data show that the skin application of paclitaxel-loaded ethosomes® improved the permeation of paclitaxel in a stratum corneum-epidermis membrane model and increased its anti-proliferative activity in a squamous cell carcinoma model as compared to the free drug. " 11/01/2013 - "The aim of this study was to establish a new paclitaxel (PTX)-resistant human esophageal squamous carcinoma (ESCC) cell line and investigate its biological characteristics. "
5.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 07/01/2000 - "We report a 63-year-old man with an in situ squamous cell carcinoma located on a chronic radiodermitis area in a finger, treated successfully with PDT. " 04/01/2005 - "ATX-S10(Na) PDT more effectively eliminated UVB-induced AK and squamous cell carcinoma (SCC) than ALA PDT. " 04/01/2014 - "The results of this study provide proof of concept for the use of macrophages as a delivery vector of AuNS for photothermal enhancement of the effects of PDT on squamous cell carcinoma. " 09/01/2013 - "This study is a retrospective comparison of PDT with transoral surgery in the treatment of early primary squamous cell carcinoma of the oral cavity/oropharynx. " 03/01/2012 - "The aim of this study was to directly monitor and quantify microcirculatory changes following tissue illumination by PDT for oral squamous cell carcinoma. "
6.	Epidermal Growth Factor Receptor (EGF Receptor)IBA 06/01/2008 - "The purpose of this study was to determine whether the efficacy of taxoid treatment combined with epidermal growth factor receptor (EGFR) inhibition is dose and sequence dependent in head and neck squamous cell carcinoma. " 05/01/2014 - "The aim of this study was to assess the impact of epidermal growth factor receptor (EGFR) expression on prognosis of lip squamous cell carcinoma (LSCC) and to relate it with clinicopathological features. " 12/01/2013 - "The epidermal growth factor receptor is frequently overexpressed in penile squamous cell carcinomas: a tissue microarray and digital image analysis study of 112 cases." 08/01/2013 - "The purpose of this study was to describe the relationship of p16 and epidermal growth factor receptor (EGFR) expression with survival in surgically treated patients who had oropharyngeal or oral cavity squamous cell carcinoma (SCC). " 01/01/2013 - "Although epidermal growth factor receptor (EGFR) inhibitor treatment showed modest response in several clinical trials in esophageal squamous cell carcinoma (ESCC) patients, it has been reported that the frequency of EGFR mutations varied largely. "
7.	docetaxel (Taxotere)FDA Link 01/01/2013 - "This case suggested that chemoradiotherapy consisting of docetaxel +nedaplatin may be effective and safe for treating anal canal squamous cell carcinoma." 07/01/2013 - "Addition of docetaxel in the treatment regimen has shown improvement in survival of head and neck squamous cell carcinoma (HNSCC) patients. " 05/01/2013 - "In the present study, the cytotoxicity of docetaxel towards human oral squamous cell carcinoma (OSCC) cell lines (HSC-2, HSC-3, HSC-4) and human oral normal cells (gingival fibroblasts, pulp cells, periodontal ligament fibroblasts) was investigated. " 04/01/2010 - "This study evaluated the docetaxel-based definitive concomitant chemoradiotherapy in patients with esophageal squamous cell carcinoma to determine its clinical response and overall survival. " 08/01/2007 - "A phase II study was conducted to evaluate the antitumor activity and adverse effects of docetaxel in patients with previously treated squamous cell carcinoma of the cervix. "
8.	PlatinumIBA 11/01/2013 - "Forty patients with uterine cervical squamous cell carcinoma in International Federation of Gynecology and Obstetrics stage IIb or IIIb, treated with platinum-based concomitant chemoradiotherapy between May 2007 and December 2012, were enrolled in this trial. " 11/01/2009 - "The present study aimed to investigate whether ERCC1 predicts the response to CDDP-based chemoradiotherapy (CRT) in patients with esophageal squamous cell carcinoma (ESCC) and to evaluate the association between ERCC1 and platinum drug sensitivity in ESCC cell lines. " 08/01/2015 - "Based on level I evidence, postoperative platinum-based radiochemotherapy (PORCT) is the recommended standard of care in defined risk situations after resection of squamous cell carcinomas of the larynx and hypopharynx (LHSCC). " 04/15/2015 - "To explore the carcinostatic effects of platinum nanocolloid (Pt-nc) combined with gamma rays on human esophageal squamous cell carcinoma (ESCC). " 04/15/2015 - "Carcinostatic effects of platinum nanocolloid combined with gamma irradiation on human esophageal squamous cell carcinoma."
9.	Interleukin-2 (IL2)IBA 02/01/2003 - "To assess the efficacy of combination therapy with IL-2 gene transfer and radiation in an immunocompetent murine model that parallel more closely the clinical therapy of head and neck Squamous cell carcinoma(HNSCC). " 01/01/1990 - "Cytolytic activation of peripheral blood lymphocytes by recombinant interleukin-2 (rIL-2) in patients with squamous cell carcinoma (SCC) of the head and neck may be inhibited by serum blocking factors, and this could influence therapeutic efficacy. " 07/01/1989 - "The data obtained indicate that local adoptive immunotherapy with IL-2 and an adequate dose of LAKc may be effective in preventing the in vivo growth of established squamous cell carcinomas of the head and neck." 07/01/2002 - "Improved survival with perilymphatic interleukin 2 in patients with resectable squamous cell carcinoma of the oral cavity and oropharynx." 10/01/2011 - "This study evaluates the immune impairment in patients with primary squamous cell carcinoma of the oral cavity and the effect of IL-2 administration on restoration of the immune responses. "
10.	Bleomycin (Blenoxane)FDA LinkGeneric 01/01/1997 - "Bleomycin (BLM) is a natural antibiotic, toxic to dividing cells (G2/M-phase), also proven effective in squamous cell carcinomas (SCC). " 01/01/1991 - "Bleomycin, an antitumor antibiotic, was effective in temporarily reducing the size of a metastatic squamous cell carcinoma in a ferret. " 05/01/1997 - "Thus the antitumor effects of bleomycin in mice can be considerably potentiated by local electric pulses, suggesting that electrochemotherapy with bleomycin may have promise for treatment of vulvar or ectocervical squamous cell carcinomas with early invasion." 03/01/1985 - "[Long-term prognosis of oral squamous cell carcinoma histologically judged to have been eliminated by the treatment with bleomycin alone]." 07/01/1984 - "An appraisal of the efficacy of bleomycin in epidermoid carcinoma of the penis."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 04/01/2010 - "Although we could not provide sufficient chemotherapy and radiation therapy due to severe side effects, squamous cell carcinoma of the anal canal responded extremely well with a marked decrease in complete response. " 08/27/1988 - "Although surgical resection is the best treatment for squamous cell carcinoma, new trends in pre-operative chemotherapy should provide better results. " 09/01/1989 - "Although newer combined modality approaches, including neoadjuvant cytotoxic chemotherapy, for patients with squamous cell carcinoma (SCCA) of the head and neck have produced high initial complete response rates, they have not improved overall survival for patients with advanced disease. " 01/01/2013 - "Despite advances in surgical technique, radiation therapy and chemotherapy, the mortality from head and neck squamous cell carcinoma (HNSCC) has not improved significantly. " 08/01/2011 - "Patients with squamous cell carcinoma of the anal margin have a high probability of cure with sphincter preservation after RT with or without concurrent chemotherapy."
2.	Radiotherapy 01/01/1990 - "The results of radical radiotherapy for operable squamous cell carcinoma of the oesophagus were similar to the best results achieved by surgical resection in other series in which there is comparable staging. " 03/01/2015 - "To evaluate the efficacy of postoperative radiotherapy for oral cavity squamous cell carcinoma (OCSCC) by comparing outcomes of high-risk subgroups. " 10/15/2013 - "Strong expression of survivin is associated with positive response to radiotherapy and improved overall survival in head and neck squamous cell carcinoma patients." 05/01/2010 - "The mean electroglottogram approximate entropy of the glottic squamous cell carcinoma patients was significantly lower prior to treatment, at 0.227 (range 0.001-0.397; p < 0.0005), but improved after radiotherapy to 0.277 at three to six months and 0.282 at one year. " 05/01/2009 - "In case of suspicion for residual or recurrent head and neck squamous cell carcinoma after surgery or (chemo)radiotherapy, fluoro-2-deoxy-D-glucose-PET has a high sensitivity and seems to be cost-effective in selecting patients for direct laryngoscopy. "
3.	Neck Dissection (Radical Neck Dissection) 07/01/1994 - "Routine bilateral neck dissection is beneficial in the surgical management of squamous cell carcinoma of the supraglottic larynx." 07/01/1997 - "The efficacy of extending the application of selective neck dissection to include more-extensive neck disease in patients with squamous carcinoma of the upper aerodigestive tract remains controversial. " 05/01/2006 - "The purpose of this study is to evaluate the efficacy of the lateral neck dissection (LND) for elective treatment of the clinically node negative neck (cN0) in laryngeal squamous cell carcinoma (SCC). " 10/01/2002 - "The purpose of this study was to evaluate the efficacy of selective neck dissection (SND) for elective treatment of the clinically negative neck in head and neck squamous cell carcinoma (SCC). " 04/01/2002 - "The aim of our study was to assess the value of positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) for the staging of clinically nodal negative necks in oral and oropharyngeal squamous cell carcinoma (SCC) using sentinel lymph node (SLN) biopsy and elective neck dissection (END) as "gold standard" for comparison. "
4.	Heterologous Transplantation (Xenotransplantation) 01/01/2014 - "In the present study, we explored the mechanism of chemopreventive/chemotherapeutic efficacy of GBT against human squamous cell carcinoma without cytotoxicity in normal cells and proved the efficacy of GBT through performing in vivo xenograft assay. " 12/01/1995 - "We, therefore, performed an in vivo study to determine the efficacy of the combination of these two drugs using two human head and neck squamous cell carcinoma xenograft lines, subcutaneously growing in athymic nude mice. " 07/15/2015 - "To evaluate the efficacy of low-dose pulsed radiation therapy (PRT) in 2 head and neck squamous cell carcinoma (HNSCC) xenografts and to investigate the mechanism of action of PRT compared with standard radiation therapy (SRT). " 02/01/2013 - "Both HSC-3 and SCC-4 human tongue squamous carcinoma cell lines and an HSC-3 xenograft mouse model were used to test the anti-growth efficacy of NAC in vitro and in vivo, respectively. " 01/01/2015 - "Results of an in-vivo efficacy study showed that Ec-LDP-TRAIL at a dose of 10 mg/kg decreased the growth of epidermoid carcinoma A431 xenografts by 80.19% (P < 0.01) on day 26. "
5.	Photochemotherapy (Photodynamic Therapy) 07/01/1993 - "Photodynamic therapy, which uses a photosensitizing agent, is effective for managing early superficial squamous cell carcinoma. " 01/01/1997 - "Photodynamic therapy with the photosensitizer HPPH-23 was safe and effective in treating early stage squamous cell carcinomas of the feline nasal plane and facial skin. " 01/01/1997 - "The purpose of this study was to assess the safety and efficacy of photodynamic therapy using a new photosensitizer in the treatment of squamous cell carcinomas of the feline facial skin. " 05/01/2008 - "Local photodynamic therapy for equine squamous cell carcinoma: evaluation of a novel treatment method in a murine model." 02/01/2015 - "The efficacy of photodynamic therapy in the treatment of oral squamous cell carcinoma: a meta-analysis."