Abstract | BACKGROUND: OBJECTIVES: ANIMALS AND METHODS: We fed a locally inbred, 8 months old mice, a high fat diet (HFD) to induce diabetes. These mice gained weight and became insulin resistant. The β2 agonist salbutamol had a beneficial effect on both glucose tolerance and insulin sensitivity after 4 weeks. RESULTS:
Salbutamol beneficial effect persisted after 4 weeks of its discontinuation. HFD caused an up regulation of the hepatic PGC-1 α expression by 5.23 folds (P< 0.041) and salbutamol reversed this effect and caused a down regulation by 30.3 folds (P< 0.0001). PGC-1 α and GLUT4 expression in the muscle was not affected by salbutamol (P> 0.05). CONCLUSION: Down regulation of the liver's PGC-1 α contributes to the beneficial effect of the chronic β2 stimulation on glucose tolerance and insulin sensitivity in T2DM mice.
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Authors | N Saleh, H E Elayan, M Zihlif |
Journal | Acta endocrinologica (Bucharest, Romania : 2005)
(Acta Endocrinol (Buchar))
2018 Apr-Jun
Vol. 14
Issue 2
Pg. 184-191
ISSN: 1841-0987 [Print] Romania |
PMID | 31149256
(Publication Type: Journal Article)
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