Abstract | ETHNOPHARMACOLOGICAL RELEVANCE:
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by failure of spontaneous resolution of inflammation. The stem of Kadsura heteroclite (KHS) is a well-known anti-arthritic Tujia ethnomedicinal plant, which named Xuetong in folk, has long been used for the prevention and treatment of rheumatic and arthritic diseases. AIM OF THE STUDY: The analgesic and anti-inflammatory effects and the potential mechanisms behind such effects of KHS would be investigated by using different animal models. MATERIALS AND METHODS: RESULTS: The maximal tolerated single dose of KHS was determined to be 26 g/kg in both sexes of mice. Pharmacological studies showed that KHS at the dose of 200 mg/kg significantly prolonged the reaction time of rats to radiant heat stimulation and suppressed abdominal writhing episodes of mice induced by intraperitoneal injection of acetic acid. KHS at the dose of 200, 400, and 800 mg/kg, showed dose-dependent inhibition of xylene-induced ear swelling in mice. KHS at the dose of 100, 200, 400, and 800 mg/kg demonstrated dose- and time-dependent suppression of paw edema induced by subcutaneous injection of carrageenan in both all rats. Mechanistic studies revealed that the anti-inflammatory effect of KHS was associated with inhibition of the production of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α and effectively decreased the expression of COX and iNOS proteins in the carrageenan-injected rat serum, paw tissues and inflammatory exudates. The positive reference drug, rotundine at a dosage of 100 mg/kg and indomethacin at a dosage of 10 mg/kg were used in both mice and rat models. CONCLUSION:
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Authors | Huang-He Yu, Ye Lin, Rong Zeng, Xin Li, Ting Zhang, Shumaila Tasneem, Cong Chen, Yi-Xing Qiu, Bin Li, Jin Liao, Yu-Hong Wang, Xiong Cai, Wei Wang |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 238
Pg. 111902
(Jun 28 2019)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 31018145
(Publication Type: Journal Article)
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Copyright | Copyright © 2019 Elsevier B.V. All rights reserved. |
Chemical References |
- Analgesics
- Anti-Inflammatory Agents
- Drugs, Chinese Herbal
- Plant Extracts
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Topics |
- Analgesics
(administration & dosage, chemistry, pharmacology)
- Animals
- Anti-Inflammatory Agents
(administration & dosage, chemistry, pharmacology)
- Dose-Response Relationship, Drug
- Drugs, Chinese Herbal
- Edema
(drug therapy)
- Ethnopharmacology
- Female
- Male
- Mice
- Mice, Inbred ICR
- Pain Measurement
- Plant Extracts
(administration & dosage, chemistry, pharmacology)
- Plant Stems
(chemistry)
- Plants, Medicinal
- Rats
- Schisandraceae
(chemistry)
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