The impact of inflammation and cytokine expression of PM2.5 in AML.

Abstract

Environmental and health issues have become a major focus of research worldwide in recent years. Particulate matter with diameter ≤2.5 µm (PM2.5) is a common air pollutant that has been demonstrated to be associated with various diseases, including acute myeloid leukemia (AML). In the present study, the effects of PM2.5 on the proliferation and inflammation were assessed using three human acute myeloid cell lines (U937, HL-60 and KG-1a) in vitro. Additionally, the levels of several cytokines [interleukin (IL)-2, IL-10, IL-17A and tumor necrosis factor (TNF)α] in AML cells and Sprague Dawley rats were evaluated to investigate the effects of PM2.5 on cytokine expression in AML. The results revealed that PM2.5 was capable of enhancing inflammatory responses in AML cells, and increasing IL-2, IL-10, IL-17A and TNFα mRNA expression in AML cells to different degrees. Furthermore, PM2.5 increased IL-2 and IL-10 contents in rats following 12 weeks of exposure. These results suggested that PM2.5 may serve a role in promoting the occurrence and progression of leukemia by affecting cytokine expression, and that there may be various mechanisms active in different AML subtypes.

• Authors: Tingting Chen, Juan Zhang, Hui Zeng, Yue Zhang, Yong Zhang, Xiaohuan Zhou, Dong Zhao, Yingmei Feng, Hebing Zhou
• Journal: Oncology letters (Oncol Lett) Vol. 16 Issue 2 Pg. 2732-2740 (Aug 2018) ISSN: 1792-1074 [Print] Greece
• PMID: 30013668 (Publication Type: Journal Article)