Abstract | BACKGROUND: Qing brick tea (QBT), traditional and popular beverage for Chinese people, is an important post-fermentation dark tea. Our present study was performed to investigate the ameliorative effects of QBT aqueous extract on metabolic syndrome (Mets) in monosodium glutamate-induced obese mice and the potential mechanisms. METHOD: RESULT: QBT treatment limited gain of body weight, waistline and LEE index, improved insulin resistance and glucose intolerance, reduced lipid level in MSG mice. Content levels of MDA, ROS and protein carbonylation in skeletal muscle of QBT group were significantly improved compared to those of MSG mice. The antioxidant enzyme activities of SOD, GPx, CAT, and GR were increased in skeletal muscle of MSG mice intervened with QBT. After 20-week QBT treatment, Nrf2 signaling pathway and downstream antioxidant factors were both increased in the skeletal muscle. In addition, QBT treatment improved insulin signaling by preferentially augmenting AKT signaling, as well as increased the protein expression of GLUT4 in the skeletal muscle. CONCLUSION: Our results showed that QBT intake was effective in protecting monosodium glutamate-induced obese mice against metabolic syndrome and involved in the Nrf2 signaling pathway in the skeletal muscle.
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Authors | Wenqi Gao, Changyi Xiao, Jun Hu, Biaoxin Chen, Chunyan Wang, Bangping Cui, Pengyi Deng, Jian Yang, Zhifang Deng |
Journal | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
(Biomed Pharmacother)
Vol. 103
Pg. 637-644
(Jul 2018)
ISSN: 1950-6007 [Electronic] France |
PMID | 29679905
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Antioxidants
- NF-E2-Related Factor 2
- Nfe2l2 protein, mouse
- Plant Extracts
- Tea
- Sodium Glutamate
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Topics |
- Animals
- Antioxidants
(metabolism)
- Dose-Response Relationship, Drug
- Male
- Metabolic Syndrome
(chemically induced, metabolism, prevention & control)
- Mice
- NF-E2-Related Factor 2
(metabolism)
- Obesity
(chemically induced, metabolism, prevention & control)
- Oxidative Stress
(drug effects, physiology)
- Plant Extracts
(isolation & purification, pharmacology, therapeutic use)
- Signal Transduction
(drug effects, physiology)
- Sodium Glutamate
(toxicity)
- Tea
- Up-Regulation
(drug effects, physiology)
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