Sea cucumber saponin liposomes ameliorate obesity-induced inflammation and insulin resistance in high-fat-diet-fed mice.

Abstract

Obesity has become a worldwide concern in recent years, which may cause many diseases. Much attention has been paid to food components that are considered to be beneficial in preventing chronic metabolic diseases. The present study was conducted to investigate the effects of sea cucumber saponin liposomes on certain metabolic markers associated with obesity. C57/BL6 mice fed with high-fat diet were treated with different forms of sea cucumber saponins for eight weeks. The results showed that liposomes exhibited better effects on anti-obesity and anti-hyperlipidemia activities than the common form of sea cucumber saponins. Sea cucumber saponin liposomes could also effectively alleviate adipose tissue inflammation by reducing pro-inflammatory cytokine releases and macrophage infiltration. Moreover, sea cucumber saponin liposomes improved insulin resistance by altering the uptake and utilization of glucose. Taken together, our results indicated that the intake of sea cucumber saponin liposomes might be able to ameliorate obesity-induced inflammation and insulin resistance.

• Authors: Cheng Chen , Xiuqing Han , Ping Dong , Zhaojie Li , Teruyoshi Yanagita , Changhu Xue , Tiantian Zhang , Yuming Wang
• Journal: Food & function (Food Funct) Vol. 9 Issue 2 Pg. 861-870 (Feb 21 2018) ISSN: 2042-650X [Electronic] England
• PMID: 29292463 (Publication Type: Journal Article)

Chemical References

• Anti-Obesity Agents
• Liposomes
• Saponins
• Glucose

Topics

• Adipose Tissue (drug effects, metabolism)
• Animals
• Anti-Obesity Agents (administration & dosage, chemistry)
• Diet, High-Fat (adverse effects)
• Drug Delivery Systems
• Glucose (metabolism)
• Humans
• Insulin Resistance
• Liposomes (administration & dosage, chemistry)
• Male
• Mice
• Mice, Inbred C57BL
• Obesity (drug therapy, etiology, immunology, metabolism)
• Saponins (administration & dosage, chemistry)
• Sea Cucumbers (chemistry)