Saponins

A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.

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Networked: 2975 relevant articles (223 outcomes, 488 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhang, Wei: 26 articles (02/2024 - 02/2008)
2.	Man, Shuli: 21 articles (05/2024 - 10/2010)
3.	Gao, Wenyuan: 20 articles (05/2024 - 10/2010)
4.	Yuan, Ding: 20 articles (07/2023 - 03/2012)
5.	Li, Wei: 19 articles (04/2024 - 02/2007)
6.	Liu, Yang: 18 articles (04/2023 - 09/2008)
7.	Wang, Ting: 18 articles (12/2021 - 03/2012)
8.	Tang, Hai-Feng: 16 articles (03/2024 - 05/2005)
9.	Tang, Haifeng: 16 articles (10/2021 - 02/2008)
10.	Melzig, Matthias F: 16 articles (10/2018 - 08/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/15/2021 - "Steroidal saponins are one of important resources for anti-tumor agent and may be benefited to selectively clear GSCs. " 08/16/2022 - "spina-christi has anticancer activity, and the saponinosomes prepared in this work can control tumor growth, improve therapeutic efficacy, and reduce the side effects of saponins." 06/01/2008 - "The review also describes saponins in combination with conventional tumor treatment strategies, which result in improved therapeutic success. " 03/30/2024 - "This study presents a novel visualization of the research on polyphyllin saponins in the field of highly prevalent cancers using bibliometric analysis. " 07/31/2023 - "It is reported that steroidal saponins effectively inhibit the hallmarks of cancer, but poor bioavailability and insufficient preclinical studies limit their utilization."
2.	Infections 07/01/2017 - "The protective efficacy of the rEnolase plus saponin combination was investigated in BALB/c mice against Leishmania infantum infection. " 01/01/2008 - "vannamei immersed in water containing saponin at 2mgL(-1) or less exhibited an immunomodulatory effect, as well as protection against V. alginolyticus infection." 12/01/1991 - "GST-45W gave up to 94% protection against challenge infection when used to vaccinate sheep with saponin as adjuvant. " 07/01/2020 - "The effect of Panax notoginseng saponins on oxidative stress induced by PCV2 infection in immune cells: in vitro and in vivo studies." 11/01/2011 - "[Study on correlations between total saponins content in rhizome or mycorrhizal infection rate of Pairs polyphylla var. yunnanensis and soil factors]."
3.	Inflammation (Inflammations) 12/01/2023 - "In this study, we identified the optimal microwave extraction protocol for saponins from A. bidentate, evaluated their protective effects against IL-1β-induced inflammation in SW1353 human chondrocytes, and explored their protective pathway. " 07/01/2023 - "Previous studies have demonstrated that the total saponins from Panax japonicus (TSPJ) can reduce HFD-induced adipocyte inflammation, but the underlying mechanism remains unclear. " 07/05/2022 - "Soybean flour with a high saponin content has been used in many studies to induce intestinal inflammation in zebrafish larvae. " 01/01/2022 - "Numerous studies have manifested that dietary soybean saponin, an anti-nutrient factor in soybean meal, may slow growth and induce intestinal inflammation in aquatic animals, but the possible causes are unclear. " 04/01/2024 - "Critical review on anti-inflammation effects of saponins and their molecular mechanisms."
4.	Visceral Leishmaniasis (Kala Azar) 05/01/2006 - "Our results confirm in the Riedel de Haen saponin extract the presence of deacylsaponins normonoterpene-deprivated which are non-toxic and capable of inducing a specific and strong immunoprotective response in vaccination against murine visceral leishmaniasis." 04/01/2015 - "Studies on cocktails of 31-kDa, 36-kDa and 51-kDa antigens of Leishmania donovani along with saponin against murine visceral leishmaniasis." 01/08/2010 - "Leishmune, the first licensed vaccine for prophylaxis against canine visceral leishmaniasis (CVL) and is also immunotherapeutic when used with double saponin adjuvant concentration. " 08/14/2007 - "In order to assess the immunotherapeutic potential on canine visceral leishmaniasis of the Leishmune vaccine, formulated with an increased adjuvant concentration (1mg of saponin rather than 0.5mg), 24 mongrel dogs were infected with Leishmania (L.) chagasi. " 01/08/2010 - "Immunotherapy with the saponin enriched-Leishmune vaccine versus immunochemotherapy in dogs with natural canine visceral leishmaniasis."
5.	Carcinoma (Carcinomatosis) 01/01/2020 - "The purpose of this study was to investigate the effects of total saponins from Lilium lancifolium (TSLL) on proliferation, apoptosis and migration of human gastric carcinoma cells lines SGC-7901 and HGC-27 and its underlying mechanism. " 01/01/2017 - "This study provides valuable information about the apoptotic inducing effect of saponin fraction, which can offer new insights into the anticancer potential of saponin as a promising candidate against human cervical carcinoma." 01/01/2012 - "In this study, we report the cytotoxic activity of the total saponins of Tupistra chinensis Baker (TST) against several carcinoma cell lines, including A549, MCF-7 and HeLa cells with the IC50 values of 4.11 μg/ml, 6.47 μg/ml and 7.78 μg/ml respectively. " 06/01/2023 - "T52 is a steroidal saponin extracted from the traditional Chinese herb Rohdea fargesii (Baill.), and it is reported to possess strong anti-proliferative capabilities in human pharyngeal carcinoma cell lines. " 01/01/2020 - "Total saponins from Lilium lancifolium: a promising alternative to inhibit the growth of gastric carcinoma cells."

Related Drugs and Biologics

1.	Vaccines
2.	Triterpenes
3.	Antigens
4.	Ginsenosides
5.	Flavonoids
6.	Alkaloids
7.	Fluorometholone (FML)
8.	Antioxidants
9.	saponin QA-21V1 (QS21)
10.	Glycosides

Related Therapies and Procedures

1.	Therapeutics
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Ligation
4.	Oral Administration
5.	Injections