Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of α-Fe2O3 nanoparticles.
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| Abstract |
Iron-oxide nanoparticles (NPs) generated by environmental events are likely to represent health problems. α-Fe2O3 NPs were synthesized, characterized and tested in a model for toxicity utilizing human whole blood without added anticoagulant. MALDI-TOF of the corona was performed and activation markers for plasma cascade systems (complement, contact and coagulation systems), platelet consumption and release of growth factors, MPO, and chemokine/cytokines from blood cells were analyzed. The coronas formed on the pristine α-Fe2O3 NPs contained contact system proteins and they induced massive activation of the contact (kinin/kallikrein) system, as well as thrombin generation, platelet activation, and release of two pro-angiogeneic growth factors: platelet-derived growth factor and vascular endothelial growth factor, whereas complement activation was unaffected. The α-Fe2O3 NPs exhibited a noticeable toxicity, with kinin/kallikrein activation, which may be associated with hypotension and long-term angiogenesis in vivo, with implications for cancer, arteriosclerosis and pulmonary disease.
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| Authors | Kristina N Ekdahl, Padideh Davoodpour, Barbro Ekstrand-Hammarström, Karin Fromell, Osama A Hamad, Jaan Hong, Anders Bucht, Camilla Mohlin, Gulaim A Seisenbaeva, Vadim G Kessler, Bo Nilsson |
| Journal | Nanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 14 Issue 3 Pg. 735-744 (04 2018) ISSN: 1549-9642 [Electronic] United States |
| PMID | 29277639 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
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